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Core/shell type magnetic particle product and preparing method thereof

A technology of magnetic particles and products, which is applied in the manufacture of inductors/transformers/magnets, magnetic materials, magnetic objects, etc., can solve the problems of reduced separation efficiency, reduced surface activity, and weak response ability, and achieve high chemical stability and anti-corrosion. Strong oxidation ability and good dispersion effect

Active Publication Date: 2009-09-02
SUNDIA MEDITECH COMPANY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the core of this type of particle is ferrite with weak magnetic field, which makes the response ability of this type of particle weak to the external magnetic field, and it is necessary to apply a high-strength external magnetic field to realize the enrichment of the particle.
In addition, the magnetic response capability of particles can also be enhanced by increasing the number of nanoparticles in the core (resulting in larger particles), but the decrease in specific surface area caused by the increase in particle diameter will lead to a decrease in surface activity, which will directly reduce the separation efficiency.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Preparation of core-shell magnetic particle core

[0024] 0.1mol / L FeCl 2 and 0.2mol / L FeCl 3 Mix with concentrated ammonia water, react for 10 minutes, add 100 times the amount of water at 10°C, stir at 5000rpm for 3 hours, the crystallization reaction of the particles is completed; centrifuge the crystallized particles at 10000rpm, and after washing, the particle size is 2~12nm Fe 3 o 4 Nanoparticles. Take 2.3 grams of Fe 3 o 4 The nanoparticles are dispersed in a mixed solvent of 500ml of ethanol, 10ml of water, and 15ml of concentrated ammonia water with a mass percentage concentration of 25% to 28%. At room temperature, 0.1mol / L of orthosilicate methyl ester is added dropwise at a stirring speed of 500rpm. After reacting for 12 hours, a black solid was separated with a 0.1T permanent magnet, and the solid was washed with distilled water for 3 to 5 times to complete the first silicon oxide coating. Disperse the first silica-coated magnetic composit...

Embodiment 2

[0025] Example 2: Preparation of core-shell magnetic particle core

[0026] 0.2mol / L FeCl 2 and 0.4mol / L FeCl 3 Mix with 2mol / L NaOH, react for 25 minutes, add 100 times the amount of water at 15°C, stir at 10000rpm for 1 hour, the crystallization reaction of the particles is completed; the crystal particles are separated by applying a magnetic field, and washed with distilled water to obtain Fe with a particle size of 2-12nm 3 o 4 Nanoparticles. Take 3.5 grams of Fe 3 o 4 Nanoparticles are dispersed in a mixed solvent consisting of 1000ml of isopropanol, 20ml of water, and 40ml of concentrated ammonia water with a concentration of 25% to 28% by mass. At room temperature, 0.6mol / L ethyl orthosilicate is added dropwise at a stirring speed of 800rpm. The ester was reacted for 20 hours, and the black solid was separated with a 0.1T permanent magnet, and the solid was washed with distilled water for 3 to 5 times to complete the first silicon oxide coating. Disperse the firs...

Embodiment 3

[0027] Example 3: Preparation of core-shell magnetic particle core

[0028] 0.3mol / L FeCl 2 and 0.6mol / L CoCl 3 Mix with concentrated ammonia water, react for 10 minutes, add 100 times the amount of water at 8°C, stir at 20,000 rpm for 4.5 hours, the crystallization reaction of the particles is completed; separate the crystal particles under a 0.1T magnetic field, and obtain the particle size after washing 2~12nm FeCo 2 o 4 Nanoparticles. Take 4.6 g FeCo 2 o 4 The nanoparticles are dispersed in a mixed solvent of 500ml propylene glycol, 10ml water, and 15ml concentrated ammonia water with a mass percentage concentration of 25% to 28%. At room temperature, 0.1mol / L orthobutyl silicate is added dropwise at a stirring speed of 500rpm. After reacting for 12 hours, a black solid was separated with a 0.1T permanent magnet, and the solid was washed with distilled water for 3 to 5 times to complete the first silicon oxide coating. Disperse the magnetic composite material coated...

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Abstract

The invention provides a core / shell type magnetic particle product and a preparing method thereof. The method comprises five steps of: preparation of magnetic oxide nanoparticles, wrapping of organic silicon source, chemical reduction, wrapping of inorganic silicon source, modification of silanized reagent with various functional groups and the like. The prepared core / shell type magnetic particle has good dispersity in water, strong magnetism of inner core matters, compact shell structure of silicon oxide, high chemical stability, strong oxidation resistance, no naked magnetic particles and good leak resistance. The product is applicable to separate and purify biological materials and medical products and can be used as carriers of biological molecules and medical molecules.

Description

technical field [0001] The invention belongs to the preparation of magnetic and nanometer materials, and relates to a method for preparing core / shell magnetic particles and its application in biological separation. technical background [0002] Magnetic particles have a wide range of applications in the fields of biomedicine, cytology and bioengineering such as separation and purification of nucleic acids and proteins, targeted drugs, cell labeling and sorting, biomolecular labeling and detection, immunoassays, and enzyme immobilization. It utilizes the magnetically controllable feature of magnetic particles. Magnetically controllable refers to the movement and enrichment of magnetic particles in a specified direction under the action of an external magnetic field. Compared with commonly used separation methods such as centrifugation, precipitation, ion exchange and chromatography, the magnetic separation of solid and liquid phases under the action of an external magnetic fi...

Claims

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Application Information

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IPC IPC(8): H01F1/00H01F41/02B22F1/02
Inventor 王晓川曾献生盛蓉生高峰
Owner SUNDIA MEDITECH COMPANY LTD
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