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Method for preparing <68>Ge sealed radioactive source

A radiation source and purpose technology, applied in the field of medical devices, can solve the problems of affecting imaging quality, poor radiation resistance, and changes in dose distribution, and achieve good adsorption effect, good uniformity, and improved accuracy

Active Publication Date: 2011-10-26
天津赛德生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method is carried out under low-concentration acidic, neutral or alkaline conditions, so the radioactive germanium-68 solution needs to be converted into a low-acid solution during the preparation process. The uniformity of filling; most ion exchange resins have poor radiation resistance, and long-term irradiation will cause the resin to age or break, resulting in changes in dose distribution and affecting the quality of imaging

Method used

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  • Method for preparing &lt;68&gt;Ge sealed radioactive source
  • Method for preparing &lt;68&gt;Ge sealed radioactive source

Examples

Experimental program
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Effect test

Embodiment 1

[0019] 68 The preparation method of Ge sealed radioactive source is made up of the following steps:

[0020] In a 15mL square quartz reaction bottle, put 2g of 120-mesh silicon dioxide as an adsorbent, add 5mL of sulfuric acid aqueous solution with a concentration of 10mol / L, and a radioactive concentration of 3mCi / mL 68 Ge aqueous solution 0.6mL, fix the reaction bottle on the rotary oscillator, under normal pressure, rotate and oscillate at a speed of 40 rpm for 60 minutes, take out the supernatant, wash the precipitate with deionized water for 3 times, and then use Wash it twice with acetone, dry it, put it into the stainless steel tube 1, weld the two ends, set the sealed stainless steel tube in the casing 2 and assemble it on the base 3, and then make a 68 Ge sealed radioactive source. The utilization rate of radioactive germanium-68 is 97%.

Embodiment 2

[0022] 68 The preparation method of Ge sealed radioactive source is made up of the following steps:

[0023] In a 15mL square quartz reaction flask, put 2g of 80-mesh silicon dioxide as an adsorbent, add 5mL of sulfuric acid aqueous solution with a concentration of 15mol / L, and a radioactive concentration of 3mCi / mL 68 Ge aqueous solution 0.6mL, fix the reaction bottle on the rotary oscillator, under normal pressure, rotate and oscillate at a speed of 30 rpm for 120 minutes, take out the supernatant, wash the precipitate with deionized water for 3 times, and then use Cleaned twice with ethanol, dried, put into stainless steel tube, welded at both ends, set the sealed stainless steel tube in the sleeve and then assembled on the base, that is to make a 68 Ge seals the radioactive source. The utilization rate of radioactive germanium-68 is 95%.

Embodiment 3

[0025] 68 The preparation method of Ge sealed radioactive source is made up of the following steps:

[0026] In a 15mL square quartz reaction bottle, put 1.5g of 200-mesh silicon dioxide as an adsorbent, add 5mL of sulfuric acid aqueous solution with a concentration of 9mol / L, and a radioactive concentration of 3mCi / mL 68 Ge aqueous solution 0.6mL, fix the reaction bottle on a rotary oscillator, under normal pressure, rotate and oscillate at a speed of 45 rpm for 30 minutes, take out the supernatant, wash the precipitate with deionized water for 3 times, and then use Cleaned twice with ethanol, dried, put into stainless steel tube, welded at both ends, set the sealed stainless steel tube in the sleeve and then assembled on the base, that is to make a 68 Ge seals the radioactive source. The utilization rate of radioactive germanium-68 is 96%.

[0027] The wall thickness of the stainless steel pipes in Examples 1-3 is 0.1 mm.

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Abstract

The present invention discloses a method for preparing a <68>Ge sealed radioactive source, which consists of the following steps: putting 0.2 to 50 g of silicon dioxide with grain diameter of 50 to 400 meshes as an adsorbent in a reaction vessel, and adding 1 to 50 mL of 8 to 15 mol / L sulfuric acid water solution, 0.1 to 10 mL of <68>Ge water solution with the radioactive concentration of 0.1 to 100 mCi / mL and 0 to 15 mL of 0.1 to 50 g / L water solution of a carrier germanium; performing stirring or oscillatory reaction on the mixture for 10 to 120 minutes under normal pressure; taking supernatant out of the reaction vessel, and washing and drying the sediment to be loaded into a stainless steel tube; and performing solder sealing on two ends of the tube, arranging the sealed stainless steel tube in a bushing, and assembling the bushing on a pedestal to prepare the <68>Ge sealed radioactive source. The method has simple and convenient preparation process, the adsorbed solution can be reused, the pollution to the environment is reduced, and the cost for treating radioactive waste is reduced.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a 68 Preparation method of Ge sealed radioactive source. Background technique [0002] Positron emission tomography (PET), also known as molecular imaging or biochemical imaging, is a new technology developed in nuclear medicine. Horizontal nuclear medicine diagnostic sign. It uses positron radionuclide-labeled drugs such as glucose, amino acids, nucleic acids, and ligands as tracers to display the metabolism, function, blood flow, cell proliferation, and receptors of cells in the body and lesion tissue at the molecular level in the form of anatomical images. Body distribution and other conditions can provide more physiological and pathological diagnostic information for clinic. PET has been widely used in clinical diagnosis of various diseases, therapeutic effect and basic medical research. Due to the inconsistency of the detector, the decay of the isotop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G21G4/08A61B6/02
Inventor 阎尔坤
Owner 天津赛德生物制药有限公司
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