Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Intracranial sirolimus medicament-release blood vessel stent and preparation method thereof

A technology of sirolimus and vascular stent, which is applied in the field of intracranial sirolimus drug-releasing vascular stent and its preparation, can solve the problem of high pressure in the balloon name associated with coronary stent and increase the difficulty of intracranial arterial stenosis angioplasty. It can reduce the incidence of stent shedding, avoid poor axial adherence of blood vessels, and reduce bending pressure.

Inactive Publication Date: 2009-12-16
万瑞飞鸿(北京)医疗器材有限公司
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Those skilled in the art know that the coronary artery is relatively straight, the soft segment of the coronary stent system is short, and the naming pressure of the coronary stent matching balloon is high (greater than 6 atmospheres), while the intracranial blood vessels are tortuous and thin-walled. There are some problems in intracranial angioplasty with stents instead of intracranial stents: first, it increases the difficulty and risk of intracranial angioplasty; second, the use of bare coronary stents or non-degradable drug-coated Coronary artery stents can lead to complications such as inflammation, subacute and late thrombosis after intracranial stent implantation, and intracranial artery restenosis after surgery cannot be effectively resolved (the incidence of restenosis in intracranial stent vessels is as high as 40% )

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Intracranial sirolimus medicament-release blood vessel stent and preparation method thereof
  • Intracranial sirolimus medicament-release blood vessel stent and preparation method thereof
  • Intracranial sirolimus medicament-release blood vessel stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] see Figure 1-3 As shown, an intracranial sirolimus drug-releasing vascular stent is a network-like structure formed of a cobalt-chromium alloy L605 tube through laser engraving and electrochemical polishing; the network-like structure includes multiple sinusoidal waveforms. The supporting rod 1 of the unit structure and the connecting rod 2 connected between the supporting rods 1; the connecting rod 2 includes a long straight line "S" type connecting rod 21 and an arc-shaped connecting rod 22; each of the supporting rods 1 consists of six One has a sinusoidal wave unit structure; the sinusoidal wave unit of the two adjacent support rods 1 adopts a corresponding form in which the trough of one support rod 1 is adjacent to the peak corresponding to the other support rod 1; the peak of one end support rod 1 A long straight line "S"-shaped connecting rod 21 is provided between the troughs corresponding to adjacent support rods 1, and the long straight line "S"-shaped conne...

Embodiment 2

[0050] An intracranial sirolimus drug-releasing vascular stent differs from Embodiment 1 in that each support rod 1 is composed of nine unit structures with sinusoidal waveforms.

[0051] The rib width of the "Ω" curved angle structure of the support rod 1 is 0.0660 mm, the width of the straight structure rib of the support rod 1 is 0.0787 mm, and the rib width of the long straight line "S" type connecting rod is 0.0635 mm.

[0052] The transverse network tube length of the vascular stent is 8mm.

[0053] A preparation method for an intracranial sirolimus drug-releasing vascular stent, the steps are as follows:

[0054] 1. Cobalt-chromium alloy L605 tubing is processed by laser engraving and electrochemical polishing to prepare a vascular stent with a network tubular structure;

[0055] II. Surface pretreatment of the network tubular structure vascular stent: use purified water to soak and clean the network tubular structure vascular support;

[0056] III. Prepare three part...

Embodiment 3

[0063] An intracranial sirolimus drug-releasing vascular stent, which is different from Embodiment 2 in that each support rod 1 is composed of seven unit structures with sinusoidal waveforms.

[0064] The rib width of the "Ω" shaped corner structure of the support rod 1 is 0.0711 mm, the width of the straight structure rib of the support rod 1 is 0.0838 mm, and the rib width of the long straight "S" type connecting rod is 0.0660 mm.

[0065] The transverse network tube length of the vascular stent is 38mm.

[0066] A preparation method for an intracranial sirolimus drug-releasing vascular stent, the steps are as follows:

[0067] 1. Cobalt-chromium alloy L605 tubing is processed by laser engraving and electrochemical polishing to prepare a vascular stent with a network tubular structure;

[0068] II. Pretreatment of the surface of the vascular stent with a network tubular structure: use acetone solvent to soak and clean the vascular stent with a network tubular structure;

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
lengthaaaaaaaaaa
lengthaaaaaaaaaa
Login to View More

Abstract

The invention relates to an intracranial sirolimus medicament-release blood vessel stent. The blood vessel stent has an integral net tubular structure which is formed by a cobalt-chromium alloy L605 tube through laser engraving and cutting and electrochemical polishing treatment; the net tubular structure comprises a plurality of support rods with sine waveform unit structures and connecting rods connected among the support rods; and the blood vessel stent is integrally coated with a sirolimus medicament-release layer. A preparation method for the blood vessel stent comprises the following steps: preparing the cobalt-chromium alloy L605 tube into the blood vessel stent of the net tubular structure through laser engraving and cutting and electrochemical polishing treatment; pre-treating the surface of the blood vessel stent of the net tubular structure; preparing sirolimus medicament coating solution; compositely spraying the sirolimus medicament solution to the surface of the blood vessel stent; and drying the sirolimus medicament-release blood vessel stent. The blood vessel stent has low nominal pressure, can effectively inhibit the neointimal formation of the blood vessel and the proliferation and migration of smooth muscle cells (SMC), and also can effectively solve the problem of intracranial arterial blood vessel restenosis.

Description

technical field [0001] The invention relates to a medical device and a preparation method thereof, in particular to an intracranial sirolimus drug-releasing vascular stent and a preparation method thereof. Background technique [0002] Research by domestic experts has shown that the distribution of atherosclerotic stenosis in the cerebral blood supply arteries of Chinese people is more common in the brain. At present, the main treatment methods for intracranial artery stenosis include drug therapy, surgical bypass grafting, and simple balloon angioplasty, etc., but they all have their own limitations, especially for patients with severe intracranial artery stenosis. The efficacy is limited. [0003] At present, there are few stents specially used for intracranial blood vessels in China. In clinical practice, coronary stents are often used instead of intracranial stents for intracranial arteriostenosis. Those skilled in the art know that the coronary artery is relatively st...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/90A61M31/00A61L27/54A61L27/04A61F2/91
Inventor 王海军王昊飞田飞
Owner 万瑞飞鸿(北京)医疗器材有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com