Biodegradable vascular support

A biodegradable and biological technology, applied in medical science, surgery, coating, etc., can solve problems such as uncontrolled, delayed stent incorporation, and affecting blood flow

Active Publication Date: 2010-01-27
HEMOTEQ AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] On the one hand, these stents have the disadvantage of dissolving so quickly and uncontrolled that some of them break down after two weeks
[0006] Another disadvantage of these stents is that the required stiffness of these segments is predetermined by the material, so compared to common stent materials such as medical stainless steel, Nitinol and cobalt/chromium stents, the stent struts have a relatively low wide and thick design
The result is a large contact surface with the surroundings, on the other hand the stent can extend further into the chamber and possibly affect blood f

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0226] The stent according to the invention consists of:

[0227] 90% (w / w) zinc

[0228] 6% (w / w) magnesium

[0229] 1% (w / w) calcium

[0230] 2% (w / w) yttrium

[0231] 1% (w / w) other metals, metal salts, non-metals (carbon, sulfur, nitrogen, oxygen, hydrogen).

[0232] The stent according to Example 1 was coated by dipping with a solution of polyethylene glycol and doxorubicin. After drying, repeat the impregnation process two more times.

example 2

[0234] The stent according to the invention consists of:

[0235] 46% (w / w) zinc

[0236] 46% (w / w) magnesium

[0237] 6% (w / w) yttrium

[0238] 2% (w / w) other metals, metal salts, non-metals (carbon, sulfur, nitrogen, oxygen, hydrogen).

[0239] At intervals, the stent according to Example 2 was coated with a solution of polylactide and the active agent paclitaxel in chloroform in a spray method. After drying, the polymer coating is melted at discontinuities by means of temperature sensors in order to form holes. Subsequently, the wells were filled with paclitaxel in DMSO and dried.

example 3

[0241] The stent according to the invention consists of:

[0242] 75% (w / w) zinc

[0243] 15% (w / w) calcium

[0244] 4% (w / w) yttrium

[0245] 0.7% (w / w) manganese

[0246] 0.8% (w / w) iron

[0247] 4.5% (w / w) other metals, metal salts, non-metals (carbon, sulfur, nitrogen, oxygen, hydrogen).

[0248] At intervals, the stent according to example 3 was coated with a solution of polygluconate in dichloromethane in a spray method. After drying, the polymer coating is melted at the discontinuities by means of acid treatment in order to form pores. After complete removal of possible residual acid by several washes and drying of the scaffold, the holes are filled with the aid of a pipette with an ethanol solution containing 30% by weight of paclitaxel and the contrast agent iopromide. Subsequently, drying is carried out at room temperature under a gentle air flow.

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PUM

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Abstract

The invention relates to biodegradable vascular supports consisting of an inner biodegradable metal skeleton and an outer polymeric coating. The biodegradable coating preferably consists of biodegradable polymers and can also contain at least one pharmacologically active substance such as an anti-inflammatory, cytostatic, cytotoxic, anti-proliferative, anti-microtubule, anti-angiogenic, anti-restenotic (anti-restenosis), anti-fungicidal, anti-neoplastic, anti-migrative, athrombogenic and/or antithrombogenic active ingredient.

Description

technical field [0001] The present invention is directed to a biodegradable stent consisting of an inner biodegradable metal framework and an outer polymer coating. The biodegradable coating preferably consists of a biodegradable polymer and may further contain at least one pharmacologically active substance such as an anti-inflammatory agent, a cytostatic agent, a cytotoxic agent, an antiproliferative agent, an anti-tubulin agent, an anti- Angiogenic, antirestenotic or anti-restenosis, antifungal, antineoplastic, antimigratory, nonthrombogenic and / or antithrombogenic agents. Background technique [0002] Today, implanting a stent is a common surgical procedure for the treatment of strictures. Recent studies have shown that narrowed vessels do not have to be permanently expanded by means of endoprostheses, especially stents. Since the presence of the stent-prosthesis in the tissue enables the regeneration of the narrowed part of the vessel and then remains dilated even wit...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/10A61L31/02A61L31/16
Inventor 艾利克·霍夫曼迈可·霍夫曼罗兰·河瑞斯
Owner HEMOTEQ AG
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