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Rhodiola rosea extract pallet and preparation method thereof

An extract, Rhodiola rosea technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of gastric mucosa irritation, long disintegration time, low bioavailability, etc., to achieve local irritation elimination, effective Good, high bioavailability effect

Inactive Publication Date: 2010-05-12
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Rhodiola rosea extract products are well received by consumers. These products are basically ordinary tablets and capsules, but the above dosage forms have a long disintegration time and disintegrate at a certain point in the body. Some irritation to gastric mucosa, low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take the following ingredients for the recipe

[0032] Rhodiola Rosea Extract

30g

microcrystalline cellulose

66g

Hydroxypropylmethylcellulose

4g

[0033] Prepare pellet formulations as follows:

[0034] (1) Get the rhodiola rosea extract of the above-mentioned formula amount and add microcrystalline cellulose, pulverize to micronization level with a ball mill, and mix;

[0035] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0036] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0038] Take the following ingredients for the recipe

[0039] Rhodiola Rosea Extract

50g

sucrose

48g

Polyvinylpyrrolidone

2g

[0040] Prepare pellet formulations as follows:

[0041] (1) Get the rhodiola rosea extract of the above-mentioned formula amount and add sucrose, pulverize to micronization level with a ball mill, and mix well;

[0042] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0043] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0045] Take the following ingredients for the recipe

[0046] Rhodiola Rosea Extract

76g

starch

20g

Polyvinylpyrrolidone

4g

[0047] Prepare pellet formulations as follows:

[0048] (1) Get the rhodiola rosea extract of the above-mentioned formula amount and add starch, pulverize to micronization level with a ball mill, and mix well;

[0049] (2) Polyvinylpyrrolidone is dissolved in an appropriate amount of water;

[0050] (3) The pellets are made by the centrifugal-fluidized pelletizing method.

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PUM

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Abstract

The invention provides a Rhodiola rosea extract pallet preparation which is prepared by Rhodiola rosea extract and pharmaceutic adjuvant, and characterized in that the pharmaceutic adjuvant is an excipient and an adhesive, wherein the pallet preparation comprises the following components by weight percent: 10%-90% of Rhodiola rosea extract, 5%-89% of excipient, and 1%-5% of adhesive. The pallet preparation can be papered as a slow-release or enteric-coated preparation according to requirements. The Rhodiola rosea extract pallet preparation has high dissolution rate and bioavailability; and the preparation method is simple, convenient, and easy to operate.

Description

Technical field: [0001] The invention relates to a micropill of natural food extract and a preparation method thereof, in particular to a micropill made of rhodiola rosea extract and a preparation method thereof. Background technique: [0002] Rhodiola rosea grows in the alpine region of Qinghai-Tibet. It is pungent in nature and bitter in taste. It has the effect of clearing heat and detoxifying, and is good at treating sore throat and lung pain. Rhodiola rosea extract is rich in starch, protein, fat, tannin, flavonoids, phenolic compounds and trace volatile oil, and also contains biologically active trace elements iron, aluminum, zinc, silver, cobalt, cadmium, titanium, Molybdenum, manganese, etc. Modern pharmacological research shows that Rhodiola extract can treat and prevent coronary heart disease, hypertension, cerebrovascular disease, menopause syndrome, neurasthenia and other diseases and the angina pectoris caused by them, and also has obvious auxiliary effects on ...

Claims

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Application Information

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IPC IPC(8): A61K36/41A61K9/16A61P11/04A61P11/00A61P9/10A61P25/00A61P25/04
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV