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Medicine composition for treating rheumatoid arthritis and preparation thereof

A rheumatoid and composition technology, which is applied in the direction of drug combination, anti-inflammatory agent, non-central analgesic, etc., can solve the problems of incomplete eradication of lesions and high recurrence rate, and achieve remarkable curative effect, quality controllable, and improved effect Effect

Active Publication Date: 2012-04-04
和光中药科技(天津)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since rheumatoid arthritis is a sterile inflammation, the above drugs can only temporarily relieve pain, eliminate inflammation, and control rheumatic activity, but cannot completely eradicate the lesion. Therefore, the recurrence rate is very high after drug withdrawal, and the patient's condition is in an alternating state of pain and relief. , if regular medication has side effects, such as nausea, vomiting, loss of appetite, tinnitus, etc.

Method used

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  • Medicine composition for treating rheumatoid arthritis and preparation thereof
  • Medicine composition for treating rheumatoid arthritis and preparation thereof
  • Medicine composition for treating rheumatoid arthritis and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation and detection of total glucosides

[0030] Take 10 kg of unique medicinal material, extract with 10 times the amount of 50% (volume) ethanol three times, each time for 1 hour, collect the extract, concentrate it to about 50L, place it at room temperature, centrifuge, and pass the supernatant through HPD-300 macroporous adsorption resin , first eluted with water until colorless, remove impurities soluble in polar solvents, discard, then elute with 4BV50% (volume) ethanol, collect the ethanol eluate, and dry the eluate after reclaiming ethanol under reduced pressure , that is, total glucosides of unique herb. Based on the total weight of the total glucosides of Solimonas glycosides, the content of total iridoid glycosides is 19.3% (weight), the content of total phenylethanol glycosides is 30.1% (weight), and the content of total flavonoids is 13.8% (weight).

[0031] The content determination method of each component in the total glucosides of Duyi...

Embodiment 2

[0047] Example 2: Preparation and detection of total alkaloids

[0048] Take 10 kg of high aconitum medicinal material, add 3 times the amount of 80% (volume) ethanol to soak for 2 hours, move it to the percolation bucket, add 10 times the amount of 80% (volume) ethanol for percolation, and the percolation speed is 0.5 per hour L, collect the percolation liquid, concentrate under reduced pressure to 2L, adjust the pH value to 10 with 2mol / l sodium hydroxide, stir after standing for 24 hours, continue to stand for 48 hours, centrifuge, take the precipitate and add 500ml of hydrogen with pH10 Sodium oxide solution, fully stirred, centrifuged, again take the precipitate and add 100ml of pH10 sodium hydroxide solution, fully stir, centrifuge, again take the precipitate and add 200ml of pH10 sodium hydroxide solution, fully stir, centrifuge, wash the precipitate with water until neutral, Dry at 100°C to obtain total alkaloids. Based on the total weight of the total alkaloids, the ...

Embodiment 3

[0054] Embodiment 3: Pharmacodynamics test

[0055] (1) The composition of the sample adopted in the pharmacodynamic test is as follows:

[0056] Table 1: The dose grouping table of the total glucosides of Duyiwei, the total alkaloids of Gaowu and the combination of the two

[0057]

[0058] (2) Analgesic test

[0059] 1) Acetic acid writhing test in mice: In this experiment, a negative control group, a positive drug group (tramadol), four dosage groups of total glucosides and total alkaloids alone, and total glucosides and Orthogonal test group of 16 groups of total alkaloids combined. From the experimental results, it can be seen that the combination of total glucosides and high-dose total alkaloids of unicorn all has a significant analgesic effect (results are shown in Table 2), wherein when the weight ratio of total glycosides and total alkaloids of uniquam is 3.37: When 0.75 and 0.84:0.75, Q value>1, showing synergy.

[0060] Table 2: Results of mouse writhing test...

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Abstract

The invention provides a medicine composition for treating rheumatoid arthritis and a preparation thereof. The composition contains lamiophlomis rotata total glycosides and high ukraine alkaloids. The medicine composition has easy acquirement of the source of the raw materials and easy industrialization, can be prepared into various medicament forms according to the requirement, provides a moderntraditional Chinese medicine with more convenient use, more effective curative effect and more controllable quality for clinic, and brings more advantages for patients, thereby generating large social benefit. Compared with the prior art, the invention has the beneficial effects that the medicine composition contains the lamiophlomis rotata total glycosides and the high ukraine alkaloids, can generate the synergistic actions of resisting inflammation, decreasing swelling and alleviating pain, enhances the effect greatly in comparison with that of independently using the lamiophlomis rotata total glycosides with the same dose or independently using the high ukraine alkaloids with the same dose and has obvious curative effect by the confirmation of pharmacodynamical experiments.

Description

technical field [0001] The present invention relates to a pharmaceutical composition and its preparation for treating rheumatoid arthritis, in particular to a pharmaceutical composition comprising total glucosides of the effective part of unique herb and total alkaloids of the effective part of aconitum aconitum and its preparation. preparation. Background technique [0002] Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease mainly characterized by joint lesions, often accompanied by extra-articular symptoms, joint cavity synovial inflammation, exudate, cell proliferation, granuloma formation, cartilage and Destruction of bone tissue, and eventually joint ankylosis and dysfunction. It has the characteristics of recurrent attacks and high disability rate. It is a common disease and frequently-occurring disease. The prevalence rate of rheumatoid arthritis in my country is 0.34%-1.46%; the disability rate accounts for about 20%-50% of the patients. . At presen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/395A61K31/70A61K36/714A61P19/02A61P29/00
Inventor 张铁军许浚申秀萍孙卫夏春英
Owner 和光中药科技(天津)有限公司