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Preparation method of water-based biological magnetic fluid

A biological magnetic and fluid technology, applied in the field of preparation of biological materials technology, can solve the problems of chemical stability and dispersion stability to be improved, nanoparticle size distribution is wide, low crystallinity, etc., and achieves magnetic response efficiency and flow rate. Controllable variable properties, narrow particle size distribution, and high crystallinity

Inactive Publication Date: 2010-06-02
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fe prepared by the classical co-precipitation method 3 o 4 The particle size distribution of nanoparticles is wide, the crystallinity is low, the impurities containing intermediates affect the purity, and the chemical stability and dispersion stability need to be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Add NaOH to DEG, raise the temperature to 100°C under nitrogen protection, and stir the reaction at 200rpm for 0.5 hours to completely dissolve NaOH in DEG, prepare a diethylene glycol monomethyl ether solution with a concentration of 0.1g / mL, and then cool and keep it at 70 ℃ for use.

[0020] Weigh ferric chloride and carboxymethyl dextran according to the ratio of 300:1 and add them to DEG to prepare a DEG solution with a concentration of 0.02g / mL, heat up to 200°C under nitrogen protection, and stir at 200rpm After reacting for 15 minutes, the diethylene glycol monomethyl ether solution was quickly injected into the above mixture (the volume ratio of the injected diethylene glycol monomethyl ether solution to the reaction mixture was 1:10), and the heating reaction was continued for 0.5 hours.

[0021] After the reaction, add acetone to the product, separate by magnetic adsorption, wash with acetone three times, and disperse in deionized water to prepare a water-bas...

Embodiment 2

[0024] Add NaOH to DEG, heat up to 120°C under nitrogen protection, and stir at 400rpm for 1 hour to dissolve NaOH in DEG completely, prepare a diethylene glycol monomethyl ether solution with a concentration of 0.3g / mL, and then cool and keep it at 80 ℃ for use.

[0025] Weigh ferric sulfate and polyethylene glycol (PEG) according to the ratio of 500:1 and add them to DEG to prepare a DEG solution with a concentration of 0.04g / mL, heat up to 220°C under nitrogen protection, and stir at 400rpm After reacting for 30 minutes, the diethylene glycol monomethyl ether solution was quickly injected into the above mixture (the volume ratio of the injected diethylene glycol monomethyl ether solution to the reaction mixture was 2:10), and the heating reaction was continued for 1 hour.

[0026] After the reaction, add acetone to the product, separate by magnetic adsorption, wash with acetone for 4 times, and disperse in deionized water to prepare a water-based biomagnetic fluid.

[0027...

Embodiment 3

[0029] Add NaOH to DEG, raise the temperature to 140°C under nitrogen protection, and stir the reaction at 600rpm for 1.5 hours to completely dissolve NaOH in DEG. ℃ for use.

[0030] Weigh ferric chloride and polyvinylpyrrolidone (PVP) according to the ratio of 1000:1 substance amount and add them to DEG to prepare a DEG solution with a concentration of 0.06g / mL, heat up to 240°C under nitrogen protection, and stir at 600rpm After reacting for 45 minutes, the diethylene glycol monomethyl ether solution was quickly injected into the above mixture (the volume ratio of the injected diethylene glycol monomethyl ether solution to the reaction mixture was 3:10), and the heating reaction was continued for 1.5 hours.

[0031] After the reaction, acetone was added to the product, separated by magnetic adsorption, washed with acetone for 5 times, and dispersed in deionized water to prepare a water-based biomagnetic fluid.

[0032] The prepared water-soluble Fe 3 o 4 Magnetic nanopar...

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PUM

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Abstract

The invention relates to a preparation method of a water-based biological magnetic fluid, belonging to the technical field of biological materials. The preparation method comprises the following steps: dissolving ferric iron salt and water-soluble high polymers in diglycol, and heating and stirring the mixture for reaction in a nitrogen protection environment; then, rapidly injecting a diglycol monomethyl ether solution and continuously heating the mixture for reaction; and further adding acetone, adsorbing for separation by a magnet, and washing and dispersing the mixture in de-ionized water to obtain the water-based biological magnetic fluid. The water-soluble Fe3O4 magnetic nanometer particles prepared by the invention have good biological compatibility, narrow particle size distribution of the nanometer particles, good uniformity, high degree of crystallization and good controllability. The prepared water-based biological magnetic fluid has good stability and biological compatibility, and the magnetic response efficiency and the rheological characteristics of the biological magnetic fluid can be adjusted and controlled through the surface characteristics of the magnetic nanometer particles, which comprise the type, the structure and the coating rate of a coating material.

Description

technical field [0001] The invention relates to a preparation method in the technical field of biomaterials, in particular to a preparation method of a water-based biomagnetic fluid using modified iron ferric oxide nanoparticles. Background technique [0002] Ferrofluid is a special smart material that has both solid strong magnetism and liquid fluidity, and has controllable rheological properties with an external magnetic field. Biomagnetic fluid is a kind of biomedical magnetic fluid, which can be applied to magnetic targeted drug delivery, intracellular hyperthermia of magnetic fluid, gene therapy and early diagnosis of tumors. Biomagnetic fluids generally consist of nano-magnetic particles, stabilizers and dispersion media. The commonly used nano-magnetic particles include pure iron powder, iron oxide, iron-cobalt alloy, etc., especially Fe 3 o 4 Most of them have a diameter of 10-30nm. The role of the stabilizer is to prevent the aggregation of magnetic particles by...

Claims

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Application Information

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IPC IPC(8): H01F1/44B01F3/12A61K47/00
Inventor 乔秀颖孙康陶可周君白明文吴静远康潇宇
Owner SHANGHAI JIAO TONG UNIV
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