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Preparation method of hydroxylapatite nano fibers or nano wires

A technology of hydroxyapatite and nanofibers, applied in nanostructure manufacturing, nanotechnology, nanotechnology, etc., can solve the problems of small specific surface area, reduced content of effective calcium components, poor biological activity, etc., and achieve uniform particle size, The effect of single shape and high purity

Inactive Publication Date: 2010-06-09
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The morphology of currently synthesized hydroxyapatite is mostly irregular short columnar or granular. As a bone substitute material in clinical use, it has a small specific surface area and high brittleness, resulting in poor biological activity and easy fracture.
Some fibers or whiskers of polymer materials or other components need to be added to increase their toughness during use, but the addition of these toughening materials reduces the content of effective calcium components, and the biocompatibility becomes poor, affecting its toughness. Functional play

Method used

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  • Preparation method of hydroxylapatite nano fibers or nano wires
  • Preparation method of hydroxylapatite nano fibers or nano wires
  • Preparation method of hydroxylapatite nano fibers or nano wires

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] At 20°C, add a certain amount of 0.2g disodium hydrogen phosphate into a two-neck round bottom flask, add 5mL 2mol·L -1 Sodium hydroxide aqueous solution, mechanically stirred for 20 minutes, added 20 mL of oleic acid ethanol mixture with a volume ratio of 1:1, continued to stir for three hours, then transferred to a hydrothermal kettle, and placed in an infrared incubator at 100°C for 5 hours. The white product in the above-mentioned hydrothermal kettle was taken out, washed 3 times with distilled water and 3 times with ethanol, centrifuged to remove the reaction residue and impurities, and finally put the white powder product in a drying oven at 75°C for 8 hours.

Embodiment 2

[0020] At 30°C, add a certain amount of 0.4g disodium hydrogen phosphate into a two-neck round bottom flask, add 8mL 2mol L -1 Sodium hydroxide aqueous solution, mechanically stirred for 20 minutes, added 20 mL of oleic acid ethanol mixture with a volume ratio of 1:1, continued to stir for three hours, then transferred to a hydrothermal kettle, and placed in an infrared incubator at 120°C for 8 hours. The white product in the above-mentioned hydrothermal kettle was taken out, washed 3 times with distilled water and 3 times with ethanol, centrifuged to remove the reaction residue and impurities, and finally put the white powder product in a drying oven at 75°C for 8 hours.

Embodiment 3

[0022] At 40°C, add a certain amount of 0.5g disodium hydrogen phosphate into a two-neck round bottom flask, add 10mL 2mol L -1 Sodium hydroxide aqueous solution, mechanically stirred for 20 minutes, added 20 mL of oleic acid ethanol mixture with a volume ratio of 1:1, continued to stir for three hours, then transferred to a hydrothermal kettle, and placed in an infrared incubator at 180°C for 10 hours. The white product in the above-mentioned hydrothermal kettle was taken out, washed 3 times with distilled water and 3 times with ethanol, centrifuged to remove the reaction residue and impurities, and finally put the white powder product in a drying oven at 75°C for 8 hours.

[0023] The X-ray diffraction figure of above-mentioned embodiment 1-3 gained product is as figure 1 As shown in the figure, the synthesized sample is hydroxyapatite, and the corresponding standard card is PDF#74-0566, Ca 10 (PO 4 ) 6 (OH) 2 , hexagonal system, space group P63 / m[176], unit cell paramet...

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Abstract

The invention discloses a preparation method of hydroxylapatite nano fibers or nano wires, comprising the following steps of: (1) adding 0.1-0.5 gram of sodium phosphates into a two-mouth round bottomed flask at 20-40 DEG C; adding 3-10 mL of 2 mol.L<-1> sodium hydroxide solutions, and mechanically stirring for 20 minutes; then adding 20 mL of oleic acid and ethanol mixing solutions with the volume ratio of 1:1, and continuously stirring for three hours; then delivering into a hydrothermal kettle; placing into an infrared insulation can at 100-180 DEG C for 5-10 hours; and (2) taking out white products inside the hydrothermal kettle; washing by distilled water for three times; washing by ethanol for three times; carrying out centrifugal separation to remove reaction residues and impurities; and finally placing the white powder products into a dry box for drying at 75 DEG C for 8 hours. The hydroxylapatite nano fibers prepared by the method have high purity, uniform grain diameter and unitary appearance.

Description

technical field [0001] The invention relates to a method for preparing nanowires, in particular to a method for preparing nanofibers or nanowire-like hydroxyapatite (HAP) by a low-temperature hydrothermal method, and belongs to the field of inorganic nanomaterials. Background technique [0002] Hydroxyapatite (hydroxyapatite, abbreviated as HA or HAP) is a kind of weakly alkaline calcium phosphate salt slightly soluble in water, the theoretical composition is Ca10(PO4)6(OH)2, it belongs to the hexagonal crystal system, and the space Group, unit cell parameters are a0=b0=0.943-0.938nm, c0=0.688-0.686nm. [0003] Hydroxyapatite (HAP) is the main inorganic component of vertebrate hard tissues. Due to its biological activity and adsorption properties for various ions and molecules, it can be used in artificial bones and teeth, biological tissue scaffolds and liquid chromatography filling. column. Dense hydroxyapatite tends to exhibit lower physical properties compared to human...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82B3/00
Inventor 黄金萍
Owner SHANGHAI NORMAL UNIVERSITY
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