Huperzine A preparation for treating schizophrenia and nervous function damage and preparation method thereof
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A technology for schizophrenia and huperzine A, applied in the field of medicine, can solve the problems of inconvenient use of patients and poor patient compliance, and achieve the effects of reducing labor intensity, being convenient to carry and taking, and reducing pollution
Inactive Publication Date: 2010-08-18
赵守明 +1
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Summary
Abstract
Description
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Problems solved by technology
The existing huperzine A injection requires intramuscular injection, which is inconvenient for patients to use and causes unnecessary pain. During long-term
Method used
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Examples
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example 1
[0015] prescription:
[0016] Huperzine A 0.1g
[0017] Ethylcellulose 6.0g
[0018] Starch 20g
[0019] Mannitol 20g
[0020] Hypromellose 20g
[0021] Aspartame 0.5g
[0022] Polysorbate 80 0.1g
[0023] Dilute hydrochloric acid ethanol 20ml
[0024] Magnesium stearate 0.5g
[0025] Made into 1000 pieces
[0026] Preparation method: Dissolve huperzine A in ethanol containing dilute hydrochloric acid. Fully dissolve, add polysorbate 80, stir evenly, become the dispersed ethanol liquid of huperzine A, spray into the mixed ethyl cellulose, starch, mannitol, hydroxypropyl cellulose, aspartame, fully Stir until uniform, add starch slurry to 20-mesh granulation, dry at 60°C, granulate to 20-mesh, add magnesium stearate, mix evenly, press into tablets, and dry to obtain.
example 2
[0028] prescription:
[0029] Huperzine A 0.1g
[0030] Croscarmellose Sodium 5.0g
[0031] Micronized silica gel 0.6g
[0032] Mannitol 40g
[0033] Aspartame 0.5g
[0034] Polyvinylpyrrolidone 5g
[0035] Magnesium Stearate 1g
[0036] Polysorbate 80 0.1g
[0037] Ethanol 20ml
[0038] Made into 1000 pieces
[0039] Preparation method: Dissolve huperzine A in ethanol. Fully dissolve, add polysorbate 80, stir evenly to become a dispersed ethanol solution of huperzine A, spray and add croscarmellose sodium, micropowder silica gel, mannitol, polyvinylpyrrolidone and aspartame which have been mixed uniformly In the supplementary material composed of sugar, fully stir until uniform, dry, add magnesium stearate to mix uniformly, and directly compress into tablets to obtain.
example 3
[0041] prescription
[0042]Huperzine A 0.2g
[0043] Micronized silica gel 37g
[0044] Mannitol 25g
[0045] Starch 35g
[0046] Polysorbate 80 0.1g
[0047] Dilute hydrochloric acid ethanol 20ml
[0048] Makes 1000 capsules
[0049] Preparation method: Dissolve huperzine A in ethanol and fully dissolve, add polysorbate 80, stir evenly to become a dispersed ethanol liquid of huperzine A, add micronized silica gel, mannitol, starch and auxiliary materials that have been mixed evenly , fully stirred until uniform, dried to obtain the huperzine A dispersion mixture, and filled into capsules to obtain huperzine A capsules.
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Abstract
The invention relates to a huperzine A preparation for treating schizophrenia and nervous function damage and a preparation method thereof. The preparation method comprises the following steps: using a solvent dispersing method and a solid-liquid phase dispersing and melting method to properly dissolve huperzine A by solvent, preparing stable huperzine A hydrochloride solution, spraying the huperzine A hydrochloride solution in an auxiliary material by dispersion, or preparing solid dispersoid mixture with uniform phase dispersion, crushing, mixing and stirring uniformly, directly adding a lubricating agent for tabletting, also being capable of adding a binding agent, granulating, drying, adding the lubricating agent, and tabletting. The phase-dispersing mixture of huperzine A also can be added with the lubricating agent with proper amount for mixing, and then filled into a capsule. The preparation is used for treating the symptoms of all the periods of schizophrenia, and has the advantages of having the effects of protecting oxidative stress toxicity of nerve cells generated by resisting Beta amyloid peptide and inducing cell apoptosis, promoting the growth of nerve growth factor, being effective for treating inflammation in cerebral hemorrhage and inflammation of cerebral ischemic injury, having long action time of drugs, being convenient to application of oral administration/containing administration and the like. The invention has high content of huperzine A preparation, stable preparation quality and good bioavailability and can improve the medication compliance of patients with schizophrenia and senile dementia.
Description
technical field [0001] The invention belongs to the field of medicine, and in particular relates to a huperzine A preparation for treating schizophrenia and nerve function damage and a preparation method thereof. Background technique [0002] The chemical name of huperzine A is (5R, 9R, 11E) 5-amino-11-ethylene-5, 6, 9, 10-tetrahydro-7methyl-5, 9-methylene-5, 9-Cyclooctatraeno(b)pyridin-2(1H)one. Huperzine A is a pure natural alkaloid extracted from Chinese herbal medicine Huperzia serrata (Thunb.) Trev (also known as Huperzia serrata, snake foot grass) and other plants. Taquancao is used in bruises, congestion, swelling, schizophrenia and other diseases, and the huperzine A contained in it is a highly efficient, reversible and highly selective central acetylcholinesterase inhibitor, which is highly effective and low in toxicity. True acetylcholinesterase has a selective inhibitory effect, easily passes through the blood-brain barrier, has a long acting time, and has the e...
Claims
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Application Information
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