PH-/temperature dual-sensitive starch derivative and preparation method thereof

A starch derivative and sensitive technology, which is applied in the field of pH-/temperature double-sensitive starch derivatives and its preparation, can solve problems that have not been reported in the literature, and achieve good surface activity, rheological properties, and biocompatibility Good, excellent effect

Inactive Publication Date: 2010-09-15
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, the preparation of pH- / temperature dual-sensitive materials from starch has not been reported in the literature.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] First, 5 grams of starch, 1 gram of sodium hydroxide, and 15 milliliters of water were added into a 100 milliliter three-neck flask, heated and stirred to 80° C. for 1 hour. Then 0.5 g of butoxypolyvinyl (polymerization degree n=1) ether glycidyl ether was added dropwise, and reacted for 5 hours. After the reaction is completed, neutralize to neutral with hydrochloric acid, wash the product with 90% by weight acetone aqueous solution, and dry it for future use. Add 6 grams of chloroacetic acid, 2.5 grams of solid sodium hydroxide, and 30 milliliters of isopropanol into a 100 ml three-necked flask and stir for 30 minutes, then add 5 grams of the starch product prepared above, continue stirring for 30 minutes, and then add solid sodium hydroxide 3 g, reacted at 40°C for 4.5 hours. After the reaction is complete, cool to room temperature, neutralize to neutral with glacial acetic acid, and wash the product several times with aqueous methanol. Dry and set aside. Add 2 g ...

Embodiment 2

[0025]First, add 10 grams of acid-thinned starch, 2 grams of sodium hydroxide, and 30 milliliters of water into a 100 milliliter three-neck flask, heat and stir to 80° C. for 1 hour. Then 3 g of glycidyl ether of methoxy polyvinyl ether (polymerization degree n=2) was added dropwise, and reacted for 5 hours. After the reaction is completed, neutralize to neutral with hydrochloric acid, wash the product with 90% by weight acetone aqueous solution, and dry it for future use. Add 3 grams of chloroacetic acid, 1.5 grams of solid sodium hydroxide, and 30 milliliters of isopropanol into a 100 ml three-necked flask and stir for 30 minutes, then add 5 grams of the starch product prepared above, and continue stirring for 30 minutes before adding solid sodium hydroxide 3 g, reacted at 40°C for 4.5 hours. After the reaction is complete, cool to room temperature, neutralize to neutral with glacial acetic acid, and wash the product several times with aqueous methanol. Dry and set aside. ...

Embodiment 3

[0027] First, add 10 grams of acid-thinned starch, 2 grams of sodium hydroxide, and 30 milliliters of water into a 100 milliliter three-neck flask, heat and stir to 80° C. for 1 hour. Then 3 g of glycidyl ether of methoxy polyvinyl ether (polymerization degree n=14) was added dropwise, and reacted for 5 hours. After the reaction is completed, neutralize to neutral with hydrochloric acid, wash the product with 90% by weight acetone aqueous solution, and dry it for future use. Add 3 grams of chloroacetic acid, 1.5 grams of solid sodium hydroxide, and 30 milliliters of isopropanol into a 100 ml three-necked flask and stir for 30 minutes, then add 5 grams of the starch product prepared above, and continue stirring for 30 minutes before adding solid sodium hydroxide 3 g, reacted at 40°C for 4.5 hours. After the reaction is complete, cool to room temperature, neutralize to neutral with glacial acetic acid, and wash the product several times with aqueous methanol. Dry and set aside...

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PUM

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Abstract

The invention relates to a pH- / temperature dual-sensitive starch derivative and a preparation method thereof, belonging to the field of functional polymer materials. The preparation method of the pH- / temperature dual-sensitive starch derivative comprises the following three steps of: firstly, reacting starch with alkyl polyoxyethylene ether glycidyl ether to introduce a -CH2CHOHCH2O-(CH2CH2-O)n-R1 group; next, further reacting the -CH2CHOHCH2O-(CH2CH2-O)n-R1 group with chloroacetic acid to introduce a -CH2COOM group; and then reacting the -CH2COOM group with alkyl halide containing C1-6 to introduce a -CH2COOR2 group so as to obtain the pH- / temperature dual-sensitive starch derivative. The pH- / temperature dual-sensitive starch derivative integrates the advantages of the starch and a pH- / temperature dual-sensitive polymer material and has the characteristics of low price, good biocompatibility, small toxicity, degradability, pH- / temperature dual-sensitive property, and the like.

Description

technical field [0001] The invention relates to a pH- / temperature double-sensitive starch derivative and a preparation method thereof, belonging to the field of functional polymer materials. This starch derivative-based smart material can be used in drug delivery, sensors, biotechnology, emulsification, smart catalysis, separation engineering and other fields. Background technique [0002] Under the stimulation of external factors, intelligent polymer materials can have corresponding mutations in some of their physical and chemical properties. Environmental stimuli include temperature, pH, solution composition, ionic strength, light intensity, electric field, stress and magnetic field, etc. Known as stimuli-responsive, stimulus-sensitive, environment-sensitive or smart polymer materials. These materials have shown very attractive potential application prospects in different fields, such as drug delivery, diagnostics, tissue engineering, biosensors, coatings, and textiles. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B31/08C08B31/00
Inventor 鄢冬茂具本植杨锦东张淑芬
Owner DALIAN UNIV OF TECH
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