The preparation method of felodipine slow-release tablet

A kind of gentle and lodipine technology, which is applied in the field of preparation of felodipine sustained-release tablets, can solve the problems of difficult industrialized production, cumbersome process, and high production cost, and achieves the advantages of easy preparation method, high product yield and reduced production cost. Effect
CN101843598BActive Publication Date: 2015-10-07CHANGZHOU PHARMA FACTORY
7 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHANGZHOU PHARMA FACTORY
Publication Date
2015-10-07

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a preparation method of felodipine sustained release tablets. The method is characterized by comprising the following steps of: mixing felodipine accounting for 1-10 percent of the total component weight, a part of hydroxypropyl methylcellulose accounting for 20-55 percent of the total component weight and a filler; and wetting by using a wetting agent to carry out wet granulation; after wet granules are dried at low temperature, mixing the dried granules with residual hydroxypropyl methylcellulose; adding a lubricating agent and then tabletting to prepare cores containing main drugs; and coating by using a coating material to obtain the felodipine sustained release tablets. The preparation method is easy to control and suitable for industrial scale production, has high product yield and reduces the production cost. Compared with merchant like preparations, the felodipine sustained release tablets obtained by using the preparation method has similar in vitro release curve.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention discloses a preparation method of felodipine sustained-release tablets. Background technique

[0002] Felodipine is a novel vascular selective dihydropyridine calcium antagonist. At present, ordinary tablets, which are widely used clinically, often need to be taken 2 to 3 times a day, and there are peaks and valleys in the drug time curve, and the blood drug concentration is too high, resulting in K + Outflow, leading to hypokalemia, felodipine sustained-release tablets only need to be taken once a day, which can effectively control blood pressure without affecting the function of the heart. Compared with ordinary preparations, it is an ideal preparation for the treatment of hypertension.

[0003] Now some patents and patent applications have reported some methods for preparing felodipine sustained-release tablets: the publication numbers are CN101103964A, CN 1640400A and CN 101292962A Chinese invention patent application and U.S. Paten...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More