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Co-mixing film of ethylene-acetic acid ethylene copolymer and polysulfone and method for preparing same

A vinyl acetate copolymer, vinyl acetate copolymerization technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc. and other problems, to achieve the effect of low complement activation, excellent mechanical properties, and non-coagulation.

Inactive Publication Date: 2010-09-29
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although today's artificial kidney has greatly improved in terms of structure and function, it is still far from the function of the human kidney.
Especially because the biocompatibility of many dialysis membranes is low, so that there are more adverse effects on patients; some membrane materials must use heparin for patients after hemodialysis, and long-term use of heparin by patients not only increases the economic burden, but also will cause serious adverse effects on patients. Cause osteoporosis, low coagulation performance and other diseases

Method used

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  • Co-mixing film of ethylene-acetic acid ethylene copolymer and polysulfone and method for preparing same
  • Co-mixing film of ethylene-acetic acid ethylene copolymer and polysulfone and method for preparing same
  • Co-mixing film of ethylene-acetic acid ethylene copolymer and polysulfone and method for preparing same

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The ingredients and mass percentages are as follows: EVA 5%, polysulfone 10%, dimethyl sulfoxide 75%, PVP (K30) 10%. Put the above raw materials into the container and mix and stir at 75°C to make a uniform spinning stock solution, and let it stand still. The prepared spinning stock solution was filtered through a 3-micron filter element, and then vacuumed and degassed at a vacuum degree of -0.6 bar to obtain a spinning solution, which was transferred to a feeding ax for later use. Heat the film-making solution to 70°C, and apply the film-making solution to a 200-mesh non-woven support layer at a speed of 20cm / min through a film scraper, and immerse the support layer coated with the film-making solution in a 45°C A composite membrane is formed in coagulation bath water, and the composite membrane is soaked in deionized water for 1 day and then dried to obtain a composite ultrafiltration membrane for blood purification.

Embodiment 2

[0032] The ingredients and mass percentages are as follows: EVA 10%, polysulfone 5%, dimethylformamide 75%, polyethylene glycol (molecular weight 10000) 10%. Put the above raw materials into the container, mix and stir at 80°C to make a uniform spinning stock solution, and let it stand still. The prepared spinning stock solution was filtered through a pore size filter element of 5 microns, and then vacuumized and degassed at a vacuum degree of -0.9 bar to obtain a spinning solution, which was transferred to a feeding ax for later use. Heat the film-making solution to 75°C, and apply the film-making solution to a 300-mesh non-woven support layer at a speed of 100cm / min through a film scraper, and immerse the support layer coated with the film-making solution in a 60°C A composite membrane is formed in coagulation bath water, soaked in deionized water for 3 days and then dried to obtain a composite ultrafiltration membrane for blood purification.

Embodiment 3

[0034] The ingredients and mass percentages are as follows: EVA 10%, polysulfone 10%, dimethylacetamide 75%, potassium nitrate 5%. Put the above raw materials into the container and mix and stir at 75°C to make a uniform spinning stock solution, and let it stand still. The prepared spinning stock solution was filtered through a 4-micron filter core, and then vacuumed and degassed at a vacuum degree of -0.8 bar to obtain a spinning solution, which was transferred to a feeding ax for later use. Heat the film-making liquid to 70°C, and apply the film-making liquid to a 300-mesh non-woven support layer at a speed of 80 cm / min through a film scraper, and immerse the support layer coated with the film-forming liquid in a 50°C A composite membrane is formed in coagulation bath water, soaked in deionized water for 2 days and then dried to obtain a composite ultrafiltration membrane for blood purification.

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Abstract

The invention relates to a co-mixing film of ethylene-acetic acid ethylene copolymer and polysulfone. The co-mixing film comprises: 5 to 10 weight percent of polysulfone, 5 to 10 weight percent of ethylene-acetic acid ethylene copolymer, 5 to 10 weight percent of hole-forming agent and 70 to 75 weight percent of organic solvent. The preparation method comprises the following steps of: 1, mixing the raw materials in part by weight to prepare uniform spinning raw liquid, standing the raw liquid; 2, filtering the spinning raw liquid by a filter core with a hole diameter of 3 to 5 micrometers, and performing vacuumizing and debubbling to obtain film-forming liquid; and 3, coating the film-forming liquid on a support layer by a film scraper to obtain the co-mixing film after the solidification of the film-forming liquid. The co-mixing film prepared by the invention has the advantages of high removing rate, low blood protein and blood platelet absorption capacity, no or fewer heparins, simple preparation process, controlled preparation process, low cost, high application values and wide application fields.

Description

technical field [0001] The invention belongs to the field of composite ultrafiltration membrane for blood purification and its preparation, in particular to a blend membrane of ethylene-vinyl acetate copolymer and polysulfone and its preparation method. Background technique [0002] Hemodialysis has been developed for more than 90 years. Dialysis membrane materials have developed from copper imitation membranes, regenerated cellulose membranes, and improved cellulose membranes to artificial synthetic membranes. Synthetic membranes are high-molecular polymers with good biocompatibility and many types. At present, commonly used synthetic membrane materials mainly include polysulfone (PS), polyacrylonitrile (PAN), polyamide (PA), polycarbonate membrane (PC), polyethersulfone (PES), polymethyl methacrylate membrane (PMMA), cellulose acetate (CA), etc. These membrane materials are widely used. At present, polysulfone is widely used because of its excellent mechanical properties...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D67/00B01D69/10A61M1/16B01D69/12
Inventor 沈新元高秋英唐勇红
Owner DONGHUA UNIV
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