The invention relates to a sterilization device, and particularly relates to a high-efficiency sterilization device for a livestock shed in animal husbandry, and aims at solving the technical problem by providing a high-efficiency sterilization device for the livestock shed in the animal husbandry, which is thorough in sterilization and high in sterilization efficiency and practicability. In order to solve the technical problem, the invention provides such a high-efficiency sterilization device for the livestock shed in the animal husbandry. The high-efficiency sterilization device for the livestock shed in the animal husbandry comprises wheels, a bottom plate, a right bracket, a left bracket, a supporting plate, a first fixed pulley, a supporting rod, a mixing box, a second fixed pulley, a first pull wire, a second pull wire, a mesh plate, a first spring, a cylinder body, a piston, a first pipeline, a first one-way valve, a feed hopper, a first connecting rod, a fixing plate, a top plate, an air cylinder, a first slide rail and the like, wherein the left side and the right side of the bottom of the bottom plate are symmetrically connected with the wheels. The high-efficiency sterilization device for the livestock shed in the animal husbandry achieves the effects of thorough sterilization, high sterilization efficiency and high practicality; when the sterilization work of the livestock shed is to be carried out, the work efficiency of the whole sterilization work can be improved by using the device.