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Cefuroxime axetil tablet and preparation method thereof

A technology of furoctidine axetil tablet and cefuroxime axetil, which is applied in the field of pharmaceutical preparations and its preparation, can solve problems such as unsatisfactory effects, and achieve the effect of smooth surface

Inactive Publication Date: 2010-11-03
华北制药集团制剂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Though this technical scheme has improved the dissolution rate of cefuroxime axetil, its effect is still not ideal enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Cefuroxime axetil 1.125kg, microcrystalline cellulose 0.79kg, sodium starch glycolate 0.19kg, cross-linked polyvinylpyrrolidone 0.45kg, calcium carbonate 0.16kg, magnesium stearate 0.014kg, white carbon black 0.008kg, containing 5 The mixed solution of % polyvinylpyrrolidone and 3% sodium lauryl sulfate (that is, add 3g sodium lauryl sulfate again in the 5% polyvinylpyrrolidone solution of 100ml) 2.4kg, make 10,000 tablets.

[0031] Pass the microcrystalline cellulose through a 60-mesh sieve, and the sodium starch glycolate and calcium carbonate through a 80-mesh sieve. Mix cefuroxime axetil, microcrystalline cellulose, 1 / 2 amount of sodium starch glycolate, 1 / 2 amount of cross-linked polyvinylpyrrolidone, and calcium carbonate, add 5% polyvinylpyrrolidone and 3% dodecane The mixed solution of sodium sulfate, stirred to make a suitable soft material, granulated with a 20-mesh sieve, dried at 40-55°C, after granulation, added the remaining sodium carboxymethyl starch and...

Embodiment 2

[0033] Cefuroxime axetil 1.375kg, microcrystalline cellulose 0.97kg, sodium starch glycolate 0.25kg, cross-linked polyvinylpyrrolidone 0.55kg, calcium carbonate 0.20kg, magnesium stearate 0.018kg, white carbon black 0.01kg, containing 10 % polyvinylpyrrolidone and 3% sodium lauryl sulfate mixed solution 2.2kg, make 10,000 tablets.

[0034] The preparation method is the same as in Example 1.

Embodiment 3

[0036] Cefuroxime axetil 1.25kg, microcrystalline cellulose 0.88kg, sodium starch glycolate 0.22kg, cross-linked polyvinylpyrrolidone 0.5kg, calcium carbonate 0.18kg, magnesium stearate 0.016kg, white carbon black 0.01kg, containing 7.5 % polyvinylpyrrolidone and 3% sodium lauryl sulfate mixed solution 2.0kg, made into 10,000 tablets.

[0037] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses a cefuroxime axetil tablet and a preparation method thereof. The cefuroxime axetil tablet comprises the following raw materials in part by mass: cefuroxime axetil, microcrystalline cellulose, carboxymethyl starch sodium, cross-linked polyvinylpyrrolidone, calcium carbonate, magnesium stearate, white carbon black, mixed liquor containing 5 to 10 percent polyvinylpyrrolidone and 3 percent lauryl sodium sulfate. The method comprises the following steps of: uniformly mixing the cefuroxime axetil, the microcrystalline cellulose, 1 / 2 of carboxymethyl starch sodium, 1 / 2 of cross-linked polyvinylpyrrolidone and calcium carbonate; adding the mixed liquor containing 5 to 10 percent polyvinylpyrrolidone and 3 percent lauryl sodium sulfate; stirring the mixture to prepare an appropriate soft material; pelletizing the material with a 20-mesh screen; and drying the material at the temperature of between 40 and 55 DEG C; adding residual carboxymethyl starch sodium, and cross-linked polyvinylpyrrolidone after pelletizing; mixing the mixture for 10 to 15 minutes; and tabletting. The cefuroxime axetil tablet can be quickly disintegrated and dissolved out within 40 to 120 seconds, has over 90 percent of dissolution after 15 minutes, and has over 98 percent of dissolution after 45 minutes.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a cefuroxime axetil tablet with antimicrobial effect and a preparation method of the tablet. Background technique [0002] Cefuroxime axetil (cefuroxime axefif, ceftin) is also known as cefadroxil tetrazole formate, cefuroxime axetil. It is a second-generation semi-synthetic cephalosporin created by British Glaxo Smith Company. It has the characteristics of broad antibacterial spectrum, strong bactericidal power, internal stability to β-lactamase, and good human pharmacokinetics. After oral administration, the blood concentration is high, and it can penetrate into sputum, bone tissue and inflammatory cerebrospinal fluid. It has little nephrotoxicity and can be administered orally. Launched by Glaxo-Wellcome in 1988, the trade name is CEFTIN. The drug releases cefuroxime after hydrolysis in the body to exert its antibacterial activity. Cefuroxime ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/546A61K47/38A61P31/04
Inventor 安英智单金海
Owner 华北制药集团制剂有限公司