Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing carotenoid microcapsules with controllable isomer proportion

A technology of carotene and isomers, which is applied in the direction of microcapsule preparation, microsphere preparation, microcapsules, etc., can solve the problem of unstable existence of β-carotene isomers, etc., with short time to achieve, high technical requirements, The effect of high bioavailability

Active Publication Date: 2010-11-10
ZHEJIANG NEW WEIPU ADDITIVE
View PDF14 Cites 18 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because it is not made into microcapsules, the β-carotene isomers cannot exist stably, and the higher processing temperature will promote the isomerization of β-carotene

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Fill the industrial chromatography column with calcium hydroxide, then add the β-carotene solution rich in cis-isomers, elute with petroleum ether, and absorb the hydrogen of 9 cis-β-carotene after the bands are completely separated Take out about 100kg of calcium oxide, put it into the autoclave, pass high-purity nitrogen gas at 500kPa for 30 minutes and evacuate, and fully dry the calcium hydroxide; heat the autoclave to 20°C, and pump dimethyl ether (cosmetic grade) into the autoclave until The pressure is 50MPa, dissolved for 10 minutes, the solution is filtered through an ultra-fine filter, and the solution is decompressed directly above the pre-prepared aqueous solution containing antioxidants and protective colloids (containing 300g gelatin, 100g sucrose, 10g VC sodium salt and 2500ml water) in the form of spray release while controlling the emulsification temperature to 40°C and homogeneous emulsification for 5 minutes. The emulsion is spray-dried to obtain micr...

Embodiment 2

[0025] Load magnesium oxide in an industrial chromatography column, then add a lycopene solution rich in cis-isomers, elute with petroleum ether / acetone, and after the bands are completely separated, the magnesium oxide that adsorbs 5 cis-lycopene Take out about 120kg, put it into the autoclave, pass high-purity nitrogen gas at 500kPa for 10 minutes and evacuate, and fully dry the magnesium oxide; heat the autoclave to 60°C, pump carbon dioxide into the autoclave until the pressure is 20MPa, dissolve for 1 minute, and the solution After being filtered through an ultra-fine filter, it is directly released in the form of a spray on the pre-prepared aqueous solution containing antioxidants and protective colloids (containing 300g gelatin, 100g sucrose, 10g VC sodium salt and 2500ml water), while controlling the emulsification temperature at 60°C And homogeneously emulsify for 30 minutes. The emulsion is spray-dried to obtain microcapsules containing 11.3% lycopene. The volume ave...

Embodiment 3

[0027] Fill the industrial chromatography column with silica gel, then add astaxanthin solution rich in cis-isomers, and elute with n-hexane / acetone. After the bands are completely separated, about 90kg of silica gel adsorbing 13 cis-astaxanthin will be added. Take it out, put it into the autoclave, pass high-purity nitrogen gas at 400kPa for 20 minutes and evacuate it, and fully dry the silica gel; heat the autoclave to 30°C, pump carbon dioxide into the autoclave until the pressure is 40MPa, dissolve for 5 minutes, and the solution is ultrafine After filtering through the filter screen, it is directly released in the form of spray on the pre-prepared aqueous solution containing antioxidants and protective colloids (containing 300g gelatin, 100g sucrose, 10g VC sodium salt and 2500ml water), while controlling the emulsification temperature to 40°C and homogenizing Emulsify for 10 minutes. The emulsion is spray-dried to obtain microcapsules containing 9.8% of astaxanthin, and ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Volume average particle sizeaaaaaaaaaa
Volume average particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for preparing carotenoid microcapsules with controllable isomer proportion, which comprises the following steps of: adsorbing the single isomer of carotenoid with a stationary phase in a chromatographic column; taking the stationary phase out, adding the stationary phase into an autoclave according to required proportion and drying the stationary phase; introducing supercritical fluid to fully dissolve the isomer adsorbed by the stationary phase; after filtering, quickly releasing the solution above aqueous solution which contains an antioxidant and a protective colloid under reduced pressure in a spraying mode, and simultaneously controlling the emulsification temperature to be between 40 and 60 DEG C; and homogenizing and emulsifying for 5 to 30 minutes and then performing spray drying to obtain the finished product of the microcapsules. The method has the advantages that: 1) the particle size of the carotenoid reaches 0.04 to 0.6mu m and the bioavailability is high; 2) the proportion of the main isomer of any type of carotenoid can be controlled as required; 3) the product purity is high and solvent residue is avoided; and 4) the configuration of the isomer in the product can be effectively ensured. The method is particularly suitable for preparing carotenoid products as required, which have the controllable isomer proportion and can be applied to different fields, so that the physiological functions of the carotenoid are maximized.

Description

technical field [0001] The invention relates to a preparation method of carotenoid microcapsules, in particular to a preparation method of carotenoid microcapsules with controllable ratio of isomers. Background technique [0002] Carotenoids (Carotenoids) widely exist in nature, and its most important representatives are β-carotene, astaxanthin, lycopene and canthaxanthin. These substances are widely used in fields such as food, cosmetics, feed and pharmaceutical industries as nutritional fortifiers and coloring agents. Carotenoids are insoluble in water, have little solubility in oil, and are very sensitive to light, heat and oxygen, so they cannot be used directly. Generally, carotenoids need to be granulated into fine particles, protected with protective colloids, and made into preparations such as microcapsules. Carotenoids can significantly increase bioavailability, improve coloring effect and reduce dosage after formulation. [0003] In addition, carotenoids are pro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): B01J13/04A23L1/30A23L1/275A23K1/16A61K9/50A61K31/015A61K8/02A61K8/31A61P3/02A61Q1/02
Inventor 仇丹吴月婵汪泠
Owner ZHEJIANG NEW WEIPU ADDITIVE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com