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Application of candida tropicalis to preparation of xylitol and application of high-purity xylitol product to pharmacy and health care

A technology of Candida tropicalis and xylitol, which is applied in the biological field and can solve problems such as high cost and cumbersome process

Active Publication Date: 2013-05-01
唐传生物科技(厦门)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0039] The purpose of the present invention is to solve the problems of cumbersome process and high cost in the existing hemicellulose hydrolysis physical chemical detoxification process

Method used

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  • Application of candida tropicalis to preparation of xylitol and application of high-purity xylitol product to pharmacy and health care
  • Application of candida tropicalis to preparation of xylitol and application of high-purity xylitol product to pharmacy and health care
  • Application of candida tropicalis to preparation of xylitol and application of high-purity xylitol product to pharmacy and health care

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0145] operation 1

[0146] Weigh 3 kg of bagasse that has been washed and re-dried, add H2SO4 solution (2.5%, w / w) at a solid-to-liquid ratio (w / v) of 1:7, hydrolyze at 120 ° C for 2 h, collect the filtrate by centrifugation, wash the filter residue once, and combine The filtrate was adjusted to pH 3 with solid calcium carbonate, and the precipitate was removed by suction filtration to obtain bagasse hemicellulose hydrolyzate. The reducing sugar content of the hydrolyzate is 3%, and xylose monosaccharide accounts for more than 80% of the total sugar.

[0147] operation 2

[0148] Take 2 kg of crushed dry corncobs, add 2% (w / w) H at a solid-to-liquid ratio of 1:7 2 SO 4 The solution was hydrolyzed at 120°C for 2 hours, the liquid part was collected, neutralized with calcium carbonate to a pH value of 3, and the precipitate was removed by suction filtration to obtain a dilute acid hydrolyzate of corncob hemicellulose. The total sugar content of the hydrolyzate is 5%, wherei...

Embodiment 2

[0170] Specific steps 1

[0171] 40kg corn husks, add 160L of water, boil. Filter off the liquid part, wash the residue once with water, add 80 L of 2% (w / w) sulfuric acid solution to the dried residue, and hydrolyze in a hydrolysis reactor at 125°C for 2 hours. Remove the residue by filtration, adjust the filtrate to pH 3 with calcium carbonate, remove the precipitate by filtration, add 1 kg of activated carbon to the filtrate, remove the activated carbon after adsorption treatment for 30 minutes, and then pass through the cation and anion exchange chromatography columns in turn to obtain a colorless and transparent syrup , and concentrated to the required concentration under reduced pressure. The content ratio of glucose, xylose and arabinose in this syrup is approximately 1:2:1.

[0172] Specific steps 2

[0173] Add 280L of 2.4% (w / w) sulfuric acid solution to 40Kg of dried bagasse, and hydrolyze at 125°C for 2 hours. The remaining subsequent processing steps are the s...

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Abstract

The invention relates to application of candida tropicalis, a microbial fermentation and separation method for preparing xylitol by using the candida tropicalis, and application of a high-purity xylitol product prepared by using the method to pharmacy and health care. The xylitol has high output quality and high yield, and the product can be used as a sweetener, a nutritional supplement and an auxiliary treatment agent for diabetes patients. Moreover, the xylitol product can serve as a medicinal intermediate for preparing health-care toothpaste, health-care chewing gum, health-care sweet foodor sweet beverage and the like.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to the use of Candida tropicalis to prepare xylitol and the pharmaceutical and health care uses of high-purity xylitol products. Background technique [0002] Hemicellulose is a polysaccharide other than cellulose in the plant cell wall. The content varies with different plants, accounting for 20-35% of the weight of the plant. It is the most abundant polysaccharide on the earth except cellulose. [0003] Cellulose is a homogeneous polysaccharide composed entirely of glucose units, while hemicellulose is mainly composed of xylose with β-(1-4) glycosidic bonds to form the main chain, and arabinose, mannose and galactose form branches. Non-uniform glycans with a chain structure. The xylan backbone of hemicellulose generally contains 50-150 xylose units, has no crystalline structure, and is bound to the surface of cellulose microfibrils. [0004] Hemicellulose is much easier to hydrolyze t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P19/02A61K31/7004A61P3/10A61P1/02A61P3/04A23L1/29C12R1/74A23L33/00
Inventor 张厚瑞覃香香蔡爱华周玉恒陈海珊
Owner 唐传生物科技(厦门)有限公司
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