Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

In-situ gel preparation of potassium dehydroandrographolide succinate and preparation method thereof

A technology of in-situ gel and Chuanhuning, which is applied in the direction of anti-inflammatory agents, pharmaceutical formulations, antiviral agents, etc., to achieve the effect of reducing the pain of medication, good antipyretic effect, and reducing the incidence of adverse reactions

Active Publication Date: 2010-12-29
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
View PDF0 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are currently no related patents and patent applications

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • In-situ gel preparation of potassium dehydroandrographolide succinate and preparation method thereof
  • In-situ gel preparation of potassium dehydroandrographolide succinate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prescription: Chuanhuning 30.0g, poloxamer 40719.0g, poloxamer 1886.0g, sodium benzoate 0.5g, appropriate amount of triethanolamine, distilled water to make up to 100g.

[0028] Preparation method: Dissolve the prescribed amount of sodium benzoate in an appropriate amount of distilled water, add the prescribed amount of Chuanhuning, adjust the pH to about 5.8, and obtain Chuanhuning water; take the prescribed amount of poloxamer 188, put it in the Chuanhuning aqueous solution, and stir to dissolve at room temperature , then add the prescribed amount of poloxamer 407, stir to disperse evenly, refrigerate in a refrigerator at 4°C for more than 48 hours to obtain a yellow and clear solution, adjust the pH to 5.8-6.2, add water to make it 100g, and fill it.

Embodiment 2

[0030] Prescription is the same as embodiment 1

[0031] Preparation method: Take the prescribed amount of sodium benzoate, poloxamer 188, and poloxamer 407, put them in an appropriate amount of distilled water, stir to disperse evenly, and refrigerate in a refrigerator at 4°C for 24 hours. After obtaining a transparent glue, add the prescribed amount of Chuanhuning. Adjust the pH to 5.8-6.2, add water to make 100g, fill it, and get ready.

Embodiment 3

[0033] Prescription: Chuanhuning 10g, poloxamer 40720.0g, poloxamer 1881.0g, hydroxypropyl β-cyclodextrin 6.0g, sodium benzoate 0.5g, triethanolamine amount, distilled water to make up to 100g.

[0034] Preparation method: Dissolve 6.0 g of sodium benzoate and 6.0 g of hydroxypropyl β-cyclodextrin in the prescribed amount of distilled water, and the remaining operating steps and methods are the same as in Example 2.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an in-situ gel preparation of potassium dehydroandrographolide succinate and a preparation method thereof. The preparation is prepared from potassium dehydroandrographolide succinate (dehydration andrographolide butanedioic acid ester single sylvite half), in-site gel substrates recognized in the field, and other pharmaceutic adjuvants necessary for other pharmacy by using water as a solvent. In-situ gel of potassium dehydroandrographolide succinate is liquid freely moving outside a body, and forms semisolid gel after patients take the gel. The invention has the advantages of definite effect, stable performance, simple preparation, convenient administration, strong compliance for patients, no toxic and side effect, no untoward effect, high bioavailability, and on the like. The in-situ gel preparation has good antipyretic and antiinflammatory action, can be used for clinically treating viral respiratory tract infection and viral pneumonia, can be used as alternative medicine for potassium dehydroandrographolide succinate injection, and is particularly suitable for infants and patients who have trouble in taking medicine.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine, and more specifically relates to a Chuanhuning in situ drug with good antipyretic effect and anti-inflammatory effect, which is the first choice for viral upper respiratory tract infection and viral pneumonia, especially for infants and patients who are inconvenient to take medicine. Gel formulation and method for its preparation. Background technique: [0002] In recent years, with the large-scale clinical application of traditional Chinese medicine injections, the problem of adverse reactions has become more and more prominent. The 10 varieties of leaf saponin sodium, puerarin and zedoary oil injection were more serious, and their adverse reaction rate accounted for 74.4% of all traditional Chinese medicine injections. Incidents of anaphylactic shock and acute death caused by adverse reactions of traditional Chinese medicine injections have been reported from time to time (Zuo Zhiy...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/365A61K47/32A61K47/34A61K47/36A61K47/38A61K47/40A61P29/00A61P31/14A61P11/00A61K47/10
Inventor 王锦玉仝燕马振山王琳王智民
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com