Two-mode nanometer fluorescence labelling material based on rare earth doped sodium gadolinium fluoride core-shell structure and preparation method thereof

Abstract

A two-mode nanometer fluorescence labelling material based on a rare earth doped sodium gadolinium fluoride core-shell structure and a preparation method thereof relate to a two-mode nanometer fluorescence labelling material with the rare earth doped sodium gadolinium fluoride core-shell structure, in particular to a method which can be used to ensure that the rare earth doped sodium gadolinium fluoride nanometer crystal can have up-conversion and down-conversion luminous modes. The preparation method is as follows: up-conversion ions and down-conversion rare earth ions are doped in the core and shell layers of the sodium gadolinium fluoride nanometer crystal respectively to obtain the two-mode nanometer fluorescence labelling material with the sodium gadolinium fluoride core-shell structure, wherein the material has monodispersity and integrates up-conversion luminescence and down-conversion luminescence. The prepared nanometer fluorescence labelling material with the sodium gadolinium fluoride core-shell structure is xRE<3+>-(1-x)NaGdF4 (RE = Ce, Pr, Nd, Pm, Sm, Eu, Tb, Dy, Ho, Er, Tm or Yb and x is 0-50mol%). A spectrometer is used to measure the luminescence of a sample; and by exciting Gd<3+> and Yb<3+>, the up-conversion luminescence and down-conversion luminescence of rare earth ions can be realized respectively.

Description

technical field [0001] The present invention relates to rare earth doped sodium fluorogadolinium (NaGdF 4 ) core-shell structure nano-fluorescence labeling material and its preparation, especially relates to a method for making the rare-earth-doped sodium fluorine-gadolinium nano-fluorescence labeling material have up-conversion and down-conversion dual-mode luminescence. Background technique [0002] Rare earth-doped alkali metal rare earth fluoride nanoparticles are a new type of luminescent material, which has broad application prospects in green lighting sources, nano-optoelectronic devices, flat panel displays, biomedical imaging, biomarkers and identification, etc. common concern of scholars. Sodium fluorogadolinium (NaGdF 4 ) has stable physical and chemical properties, low phonon energy, and is a good luminescent substrate. Gadolinium ion (Gd 3+ ) has a large energy level interval, and is often used as a sensitizing ion to realize other rare earth ions (Eu 3+ , ...

AI Technical Summary

Problems solved by technology

However, most of the current research results are to dope the up-conversion and down-conversion rare earth ions into the sodium fluorogadolinide nanocrystals respectively to realize the respective up-conversion and down-conversion luminescence of the doped rare earth ions, and the up-conversion and down-conversion luminescence are integrated into the same nanoparticle, so the multifunctionalization of rare earth-doped sodium fluorogadolinide nanomaterials cannot be realized

At the same time, most of the synthesized nanoparticles are water-insoluble, which largely limits their application in biomarkers (references: Fiorenzo Vetrone et al. The Active-Core / Active Shell Approach: A Strategy toEnhance the Upconversion Luminescence in Lanthanide-Doped Nanoparticles, Advanced Functional Materials, 19, 1-6 (2009); Chenghui Liu et al. Morphology-and phase-controlled synthesis of monodisperse lanthanide-doped NaGdF 4 Nanoparticles with multicolor photoluminescence, Journal of Materials Chemistry, 19, 489-496(2009))

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