Two-mode nanometer fluorescence labelling material based on rare earth doped sodium gadolinium fluoride core-shell structure and preparation method thereof

A rare earth doping, sodium gadolinium fluoride technology, applied in luminescent materials, chemical instruments and methods, fluorescence/phosphorescence, etc., can solve the problem that the up-conversion and down-conversion luminescence cannot be integrated into the same nanoparticle, which limits the application and cannot be realized. The multifunctionalization of sodium fluoride gadolinium nanomaterials can achieve the effects of good water solubility and biocompatibility, uniform particles, and simple preparation process.

Active Publication Date: 2011-08-03
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, most of the current research results are to dope the up-conversion and down-conversion rare earth ions into the sodium fluorogadolinide nanocrystals respectively to realize the respective up-conversion and down-conversion luminescence of the doped rare earth ions, and the up-conversion and down-conversion luminescence are integrated into the same nanoparticle, so the multifunctionalization of rare earth-doped sodium fluorogadolinide nanomaterials cannot be realized
At the same time, most of the sy

Method used

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  • Two-mode nanometer fluorescence labelling material based on rare earth doped sodium gadolinium fluoride core-shell structure and preparation method thereof
  • Two-mode nanometer fluorescence labelling material based on rare earth doped sodium gadolinium fluoride core-shell structure and preparation method thereof
  • Two-mode nanometer fluorescence labelling material based on rare earth doped sodium gadolinium fluoride core-shell structure and preparation method thereof

Examples

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example 1

[0016] Example 1: (1) NaGdF 4 : Preparation of 18%Yb, 2%Er nanocrystalline cores. Weigh 0.294g gadolinium chloride (GdCl 3 .6H 2 O), 0.0076g erbium chloride (ErCl 3 .6H 2 O) and 0.0697g ytterbium chloride (YbCl 3 .6H 2 O) join in the 100ml there-necked flask, add 5ml oleic acid and 16ml octadecene, stir to make it mix evenly. Under the protection of nitrogen flow, the above mixture was heated to 150° C. and kept at this temperature for 90 minutes to completely dissolve the rare earth chloride and obtain a transparent clear solution. After cooling to room temperature, 10 ml of methanol solution in which 0.14 g of ammonium fluoride and 0.14 g of sodium hydroxide were dissolved was added dropwise, stirred and allowed to react at room temperature for 30 minutes. Then the mixed solution was heated to 50° C. and kept for 30 minutes to remove methanol in the reaction system. After the methanol was removed, the reaction system was heated to 300° C. under the protection of nitr...

example 2

[0018] Example 2: (1) NaGdF 4 : 18% Yb, 1% Tm nanocrystalline core preparation. Weigh 0.3011g gadolinium chloride (GdCl 3 .6H 2 O), 0.0038g thulium chloride (TmCl 3 .6H 2 O) and 0.0697g ytterbium chloride (YbCl 3 .6H 2 O) join in the 100ml there-necked flask, add 4ml oleic acid and 16ml octadecene, stir to make it mix evenly. Under the protection of nitrogen flow, the above mixture was heated to 150°C, and kept at this temperature for 90 minutes to completely dissolve the rare earth chloride and obtain a transparent clear solution. After cooling to room temperature, add 0.14g of ammonium fluoride and 0.14 g of sodium hydroxide in methanol solution 10 ml, stirred and allowed to react at room temperature for 30 minutes, the mixed solution was heated to 50° C., and kept for 30 minutes to remove methanol in the reaction system. After the methanol was removed, the reaction system was heated to 300° C. under the protection of nitrogen flow, kept for 60 minutes, then stopped h...

example 3

[0020] Example 3: (1) NaGdF 4 : 18% Yb, 1% Tm, 0.5% Er nanocrystalline core preparation. Weigh 0.2992g gadolinium chloride (GdCl 3 .6H 2 O), 0.0038g thulium chloride (TmCl 3 .6H 2 O), 0.0697g ytterbium chloride (YbCl 3 .6H 2 O), 0.0019g erbium chloride (ErCl 3 .6H 2 O) join in the 100ml there-necked flask, add 4ml oleic acid and 16ml octadecene, stir to make it mix evenly. Under the protection of nitrogen flow, the above mixture was heated to 150°C, and kept at this temperature for 90 minutes to completely dissolve the rare earth chloride to obtain a transparent clear solution, which was then cooled to room temperature. Then, 10 ml of methanol solution in which 0.14 g of ammonium fluoride and 0.14 g of sodium hydroxide were dissolved was added dropwise, stirred and allowed to react at room temperature for 30 minutes. Then the mixed solution was heated to 50° C. and kept for 30 minutes to remove methanol in the reaction system. After the methanol was removed, the reac...

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Abstract

A two-mode nanometer fluorescence labelling material based on a rare earth doped sodium gadolinium fluoride core-shell structure and a preparation method thereof relate to a two-mode nanometer fluorescence labelling material with the rare earth doped sodium gadolinium fluoride core-shell structure, in particular to a method which can be used to ensure that the rare earth doped sodium gadolinium fluoride nanometer crystal can have up-conversion and down-conversion luminous modes. The preparation method is as follows: up-conversion ions and down-conversion rare earth ions are doped in the core and shell layers of the sodium gadolinium fluoride nanometer crystal respectively to obtain the two-mode nanometer fluorescence labelling material with the sodium gadolinium fluoride core-shell structure, wherein the material has monodispersity and integrates up-conversion luminescence and down-conversion luminescence. The prepared nanometer fluorescence labelling material with the sodium gadolinium fluoride core-shell structure is xRE<3+>-(1-x)NaGdF4 (RE = Ce, Pr, Nd, Pm, Sm, Eu, Tb, Dy, Ho, Er, Tm or Yb and x is 0-50mol%). A spectrometer is used to measure the luminescence of a sample; and by exciting Gd<3+> and Yb<3+>, the up-conversion luminescence and down-conversion luminescence of rare earth ions can be realized respectively.

Description

technical field [0001] The present invention relates to rare earth doped sodium fluorogadolinium (NaGdF 4 ) core-shell structure nano-fluorescence labeling material and its preparation, especially relates to a method for making the rare-earth-doped sodium fluorine-gadolinium nano-fluorescence labeling material have up-conversion and down-conversion dual-mode luminescence. Background technique [0002] Rare earth-doped alkali metal rare earth fluoride nanoparticles are a new type of luminescent material, which has broad application prospects in green lighting sources, nano-optoelectronic devices, flat panel displays, biomedical imaging, biomarkers and identification, etc. common concern of scholars. Sodium fluorogadolinium (NaGdF 4 ) has stable physical and chemical properties, low phonon energy, and is a good luminescent substrate. Gadolinium ion (Gd 3+ ) has a large energy level interval, and is often used as a sensitizing ion to realize other rare earth ions (Eu 3+ , ...

Claims

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Application Information

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IPC IPC(8): C09K11/85C09K11/02G01N21/64
Inventor 陈学元刘永升涂大涛李仁富罗文钦朱浩淼
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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