Method for preparing p-fluoro anisole
A technology of p-fluoroanisole and fluoroanisole, which is applied in the field of preparation of high-purity p-fluoroanisole, can solve the problems that the reaction cannot be carried out, is not easy and economical, and cannot carry out condensation reaction, so as to ensure the production rate effect
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[0027] (Example 1)
[0028] The p-bromofluorobenzene in the raw materials used in this example was provided by Nanjing Fustar Chemical Co., Ltd., and the methanol solution of sodium methoxide was produced by Fengshui Social Welfare Chemical Plant, Zhangdian District, Zibo City, and its specification was 28 wt%.
[0029] The preparation method of p-fluoroanisole in this embodiment includes the following steps:
[0030] ①To generate p-fluoroanisole, add 500g (2.8mol) p-bromofluorobenzene and 260g solvent DMF in a 2000mL glass reaction flask equipped with a fractionation column with 4 theoretical plates, a mechanical stirring device and a thermometer. The chemical name is dimethylformamide, which is a transparent liquid), 750g of 28wt% methanol solution of sodium methoxide (the amount of sodium methoxide is 3.92mol) and 8g of powdery catalyst cuprous chloride, on the head of the fractionation column It is also equipped with a condenser, and cooling water is passed through the condenser...
Example
[0070] (Example 2)
[0071] The remaining steps of this embodiment are the same as those of embodiment 1, except that: in step ①, when p-bromofluorobenzene reacts with liquid sodium methoxide, the catalyst used is cuprous bromide, and the amount of cuprous bromide is 10g.
Example
[0072] (Example 3)
[0073] The rest of the steps in this embodiment are the same as in embodiment 1, except that: in step ①, when the reaction system is heated under stirring to generate p-fluoroanisole, the reaction mixture is first heated from room temperature within 1 hour (In this embodiment, it is 20°C) slowly rise to 65°C, and then proceed with other operations.
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