Production method of water soluble flavone-chitosan derivative

A technology of chitosan derivatives and water-soluble flavonoids is applied in the directions of drug combinations, pharmaceutical formulations, plant raw materials, etc., and can solve the problems of poor moisture retention and bactericidal ability of products, easy precipitation of cosmetics, and unfavorable environmental protection. It is beneficial to environmental protection, the molecular weight of the hydrolyzate is uniform, and the moisturizing effect is good.

Inactive Publication Date: 2011-09-07
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of this process is that the product has low purity and contains impurities such as amino acids and sugars; the utilization rate of raw materials is low, and the water solubility of the prepared product is poor, and precipitation is easy to occur when added to cosmetics; the prepared product has poor moisture retention and bactericidal ability. Easy to brown and be polluted by microorganisms; distilled water extraction is carried out under decoction conditions, the reaction temperature is high, the production energy consumption is high, which is not conducive to energy saving; the production process produces waste liquid and waste residue, which is not conducive to environmental protection and increases production costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A method for producing water-soluble flavone-chitosan derivatives, the specific steps are as follows.

[0024] (1) Preparation of small molecule chitosan solution

[0025] Using commercially available chitosan with an average molecular weight of 45000 Da as raw material, according to the ratio of chitosan raw material mass (g): mass concentration of 0.2% hydrochloric acid solution volume (mL) ratio of 1:60, under stirring The chitosan raw material was added to the hydrochloric acid solution, stirred and mixed uniformly, and then adjusted with dilute sodium hydroxide solution to adjust its pH to 5.5, then chitosanase was added, and the reaction was carried out at a temperature of 50°C for 1 hour. The quality of the added chitosanase: chitosan raw material is 1:50. After the reaction is completed, the temperature is raised to 80°C and kept for 10 minutes, then pumped into a centrifuge for centrifugal separation. The centrifuge speed is 6000 rpm and the centrifugation time is ...

Embodiment 2

[0031] A production method of water-soluble flavone-chitosan derivative is the same as that in Example 1, wherein:

[0032] In step (1), the average molecular weight of the chitosan raw material is 50000 Da, the hydrochloric acid concentration is 0.3%, the mass (g) of the chitosan raw material: the volume of the hydrochloric acid solution (mL) ratio is 1:100, and the pH is 5.8. The temperature is 55°C, the reaction time is 1.5h, the mass ratio of chitosanase to chitosan is 1:80, the temperature is raised to 90°C, and the holding time is 15 minutes. The speed of the centrifuge is 8000 rpm, the centrifugation time is 15 minutes, the molecular weight cut-off of the sodium filter is 3000Da, and the pressure is 1.2Mpa.

[0033] In step (2), the flavonoids (i.e. ginkgo flavonoids) are used as raw materials, the mass (g) of ginkgo flavonoids: the volume of water (mL) ratio is 1:50, the pH is 10, and the stirring treatment time is 40 minutes. The mass ratio of the compound solution: ethyl...

Embodiment 3

[0036] A production method of water-soluble flavone-chitosan derivative is the same as in Example 1, wherein:

[0037] In step (1), the average molecular weight of the chitosan raw material is 55000 Da, the hydrochloric acid concentration is 0.5%, the mass (g) of the chitosan raw material: the volume of the hydrochloric acid solution (mL) ratio is 1:120, and the pH is 6.0. The temperature is 60℃, the reaction time is 2h, the mass ratio of chitosanase:chitosan is 1:100, the temperature is raised to 100℃, the holding time is 20 minutes, the centrifuge speed is 10000 rpm, the centrifugation time is 20 minutes, and the sodium filter intercepts The molecular weight is 4000 Da. The pressure is 1.8Mpa.

[0038] In step (2), the flavonoids (i.e. buckwheat flavonoids) are used as raw materials, the mass (g) of buckwheat flavonoids: the volume of water (mL) ratio is 1:60, the pH is 11, and the stirring treatment time is 50 minutes. Compound solution: ethylene glycol diglycidyl ether: the m...

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PUM

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Abstract

The invention discloses a production method of a water soluble flavone-chitosan derivative, relating to a preparation method of a flavonoid uvioresistant active substance. The production method takes chitosan and a flavone compound as raw materials, and the product is prepared by the processes of preparing a small molecular chitosan solution, synthesizing a water soluble flavone-chitosan derivative, concentrating and the like. The invention has the advantages of simple method, simplicity of operation, simple equipment, mild reaction conditions, energy conservation, full utilization of material resources in the production process, no discharge of three wastes, benefit to environmental protection, low production cost and convenience of popularization and application; and the product is characterized by being freely soluble in water, having good moistening effect and the like. The product prepared by the invention can be extensively used in skin care cosmetics and medicaments for treating skin diseases.

Description

1. Technical Field [0001] The invention belongs to the technical field of preparing functional additives for daily chemicals, and specifically relates to a method for preparing a flavonoid anti-ultraviolet active substance. 2. Background technology [0002] Ultraviolet rays can be divided into short-wave band (190-280nm), medium-wave band (280-320nm) and long-wave band (320-400nm). The main damage to the skin is medium-wave and long-wavelength ultraviolet rays. Ultraviolet rays hit the skin directly for a long time, causing acute erythema effect, causing skin flushing and accumulation of melanin. In severe cases, it may be accompanied by nausea, edema, peeling, and fever. In addition, skin that is excessively exposed to ultraviolet light can also cause skin cancer. Therefore, the research and development of functional daily chemical raw materials for skin that can reduce UV damage has important application value and broad market prospects. [0003] Many substances have the abilit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08C12P19/14A61K8/73A61K36/16A61K36/70A61K31/7048A61K47/48A61P17/00A61Q17/04A61K47/55
Inventor 周小华冯涛徐溢周兴赵红波康宏宽李晓辉
Owner CHONGQING UNIV
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