Method for preparing polyurethane material grafted by methoxy polyethylene glycol

Abstract

The invention discloses a method for preparing a polyurethane material grafted by methoxy polyethylene glycol, comprising the following steps: first, reacting dimethyl 5-hydroxyisophthalate with 3-propargyl bromide to obtain 5- propargyloxy dimethyl isophthalate; slowly adding a tetrahydrofuran solution in a tetrahydrofuran solution of lithium aluminum hydride for reacting to obtain 3,5-dihydroxytoluene-1-propargyloxy benzene; reacting methoxy polyethylene glycol with bromo-2-methylpropionyl bromide to obtain methoxy polyethylene glycol having an end group of bromine atoms; converting methoxy polyethylene glycol having the end group of bromine atoms into methoxy polyethylene glycol having an end group of azido by using sodium azide; reacting methoxy polyethylene glycol having the end group of azido by using sodium azide with dihydric alcohol 3,5-dihydroxytoluene-1-propargyloxy benzene by click chemistry; and reacting dihydric alcohol containing methoxy polyethylene glycol long tail with diisocyanate to obtain polyurethane having a main chain grafted by methoxy polyethylene glycol.

Description

technical field

[0001] The invention belongs to the field of surface functionalization of medical polymer materials, and specifically relates to the preparation of a highly stable hydrophilic and adjustable coating on the surface of medical polyurethane materials such as high-end medical catheters, guide wires and cardiovascular stents. method. Background technique

[0002] Polyurethane (PU) is mainly obtained by polyaddition of diisocyanates and diols or polyols as basic raw materials. It was first synthesized by Bayer in 1947 and has a development history of more than 60 years so far. The diversity of the main chain structure of PU determines that it has very rich and unique physical and chemical properties. Surface functionalized PU has been widely used as biomedical materials. It is grafted with polyethylene glycol (PEG) or heparin to enhance the hydrophilic lubricity of the catheter surface, anticoagulant and anti-protein deposition, and can be applied to the blood ves...