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Preparation method of medical metal implanted material porous niobium

An implant material, porous niobium technology, applied in the field of porous medical metal implant materials, can solve the problems of insufficient purity of finished products, carbon skeleton residues, and reduced biological safety, and achieve the goals of reducing impurity content, uniform quality, and increasing porosity Effect

Active Publication Date: 2012-05-30
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitations of its preparation method, the purity of the obtained finished product is not enough, and there are carbon skeleton residues, resulting in a decrease in biological safety

Method used

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  • Preparation method of medical metal implanted material porous niobium
  • Preparation method of medical metal implanted material porous niobium
  • Preparation method of medical metal implanted material porous niobium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Weigh 3 g of ethyl cellulose and put it into a container containing 240 ml of absolute ethanol; place it on an electric stove to heat and stir to make it an ethyl cellulose ethanol solution. Use a 200g balance to weigh 60g of niobium powder with an average particle size of less than 38 microns and an oxygen content of less than 0.1%, add 15ml of cooled ethyl cellulose ethanol solution, stir and mix evenly, and make it into a niobium powder slurry. Use 10×10×30mm porous polyurethane foam (average pore diameter is 0.48mm, density 0.025g / cm 3 , hardness 50°) into it and pour until the pores of the polyurethane foam are filled with niobium powder slurry, then use a clip to take out the polyurethane foam filled with niobium powder slurry and put it into a porcelain plate. Dry in a vacuum drying oven at a drying temperature of 60° C., a drying time of 6 hours, and a vacuum degree of 1 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temperatu...

Embodiment 2

[0036] Example 2: Weigh 5 g of ethyl cellulose and put it into a container containing 200 ml of absolute ethanol; place it on an electric stove to heat and stir to make it an ethyl cellulose ethanol solution. Use a 200g balance to weigh 40g of niobium powder with an average particle size of less than 38μm and an oxygen content of less than 0.1%, add 10ml of ethyl cellulose ethanol solution, stir and mix evenly, and make it into a niobium powder slurry. Use 10×10×25mm porous polyurethane foam (average pore diameter is 0.56mm, density 0.030g / cm 3 , hardness 60 0) into it and pour until the pores of the polyurethane foam are filled with the niobium powder slurry, and the polyurethane foam filled with the niobium powder slurry is taken out with a clip and put into the porcelain plate. Dry in a vacuum drying oven, the drying temperature is 70 ° C, the drying time is 5 hours, and the vacuum degree is kept at 1×10 -2 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 ...

Embodiment 3

[0039] Example 3: Weigh 6 g of ethyl cellulose and put it into a container containing 220 ml of absolute ethanol; place it on an electric stove to heat and stir to make it an ethyl cellulose ethanol solution. Use a 200g balance to weigh 45g of niobium powder with an average particle size of less than 38μm and an oxygen content of less than 0.1%, add 12ml of ethyl cellulose ethanol solution, stir and mix evenly, and make it into a niobium powder slurry. Use 8×8×25mm porous polyurethane foam (average pore size is 0.70mm, density 0.035g / cm 3 , hardness 70°) into it and pour until the pores of the polyurethane foam are filled with niobium powder slurry, then use a clip to take out the polyurethane foam filled with niobium powder slurry and put it into a porcelain plate. Dry in a vacuum drying oven, the drying temperature is 50 ° C, the drying time is 6 hours, and the vacuum degree is kept at 1×10 -1 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temperatu...

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Abstract

The invention relates to a preparation method of a medical implanted material porous niobium. The preparation method comprises the following steps: 1, preparing a niobium powder slurry from a solution prepared with ethyl cellulose as an organic binder and waterless ethanol as a dispersant and niobium powder with the average particle size of less than 38mum and the oxygen content of less than 0.1%, wherein the mass percentage concentration of the obtained ethyl cellulose waterless ethanol solution is 2-4%; 2, casting the niobium powder slurry into an organic foam; 3, drying to remove the dispersant in the organic foam casted with the niobium powder slurry; 4, degreasing in an inert gas atmosphere; 5, sintering under vacuum conditions to prepare a porous sinter, wherein there is a sintering neck structure between each two sintered niobium powder particles; and 6, annealing under vacuum conditions, and carrying out routine post-processing to obtain the porous niobium. A medical metal implanted material porous tantalum prepared in the invention has the advantages of superior biological compatibility and superior biological safety; and the porous tantalum has the sintering neck structure, so mechanical properties of ductility and the like of the medical metal implanted material porous tantalum are improved, thereby good methods are provided for the convenient and effective application of the porous tantalum in the medical metal implantation.

Description

technical field [0001] The invention relates to a porous medical metal implant material, in particular to a preparation method of porous niobium as a medical implant material. Background technique [0002] Porous medical metal implant materials have important and special purposes such as treating bone tissue trauma and femoral tissue necrosis. The common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and uniformly distributed, or partially connected and uniformly distributed according to the needs, so that it can be connected with The growth of bone tissue in the human body is consistent, and the weight of the material itself is reduced, so that it is suitable for human implantation. [0003] The porous metal material used as a medical implant is basically based o...

Claims

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Application Information

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IPC IPC(8): A61L27/04A61L27/56B22F3/11
Inventor 阮建明叶雷谢健全节云峰王志强冯华周健
Owner CHONGQING RUNZE PHARM CO LTD
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