Double-layer hollow capsule and multi-layer enteric hollow capsule

A hollow capsule, enteric-coated technology, applied in the direction of capsule transportation, can solve the problems of unqualified pellets, difficult to ensure quality, increase production costs, etc., and achieve the effects of good drug absorption, saving raw materials, and fewer processes

Inactive Publication Date: 2012-07-11
ANHUI HUANGSHAN CAPSULE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the coating is incomplete or leaked, the pellets will be unqualified
It can be seen that processing pellets not only increases production costs, but also makes it difficult to ensure quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, screen out hydroxypropyl methylcellulose, sodium carboxymethylcellulose, methylcellulose, karaya gum, xanthan gum, pullulan, polyethylene One or more kinds of gastric soluble film-forming materials such as diol, etc., use purified water as a solvent to make a 30% gastric sol solution, and then use a capsule mold to dip in the glue solution to form a film, and then continue after the film is dry Dip in gelatin glue solution, gelatin glue solution preparation takes gelatin 30kg, purified water 120kg. Pour the gelatin and water into the reaction pot, heat, stir and dissolve. The circulating water temperature of the reaction pot is 60-90°C, stir for 2-4 hours, fully melt and stir evenly, filter the glue with a 200-mesh filter bag, and store the glue in In the insulation barrel, check the specific gravity, adjust the glue concentration, add food colorings of various colors and / or a certain amount of sunscreen titanium dioxide, etc. according to the needs of use...

Embodiment 2

[0020] Embodiment 2, screen out cellulose acetate, methacrylic acid and ethyl acrylate copolymer, hydroxypropyl cellulose phthalate, hydroxypropyl methylcellulose from the series products of gastric acid-resistant enteric film-forming materials Vegetarian acetate succinate, corn cob, shellac, sodium alginate, etc. are used as raw materials and one or more kinds are mixed with ethanol and acetone or purified water as solvent to make enteric gel liquid, and then the capsule mold is dipped in enteric gel liquid to form Film, after the film is dry, then dip it in gelatin glue, and then wrap the enteric glue after the gelatin glue is dry. The preparation method of the gelatin glue is the same as that in Example 1. After drying, curing and demoulding, the inner layer is gastric acid resistant. The enteric-coated film isolation layer is outsourced with gelatin, and then coated with enteric-coated multilayer enteric-coated hollow capsules.

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PUM

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Abstract

A double-layer hollow capsule comprises a gelatine layer and is characterized in that a stomach soluble hollow capsule formed by an isolation layer made of stomach soluble membrane forming materials is arranged on the inner wall of the gelatine layer. A multi-layer enteric hollow capsule comprises a gelatine layer and is characterized in that an enteric hollow capsule formed by an isolation layer made of enteric membrane forming materials is arranged on the inner wall of the gelatine layer. The isolation layers can be resistant to acidity and alkalinity of medicines to protect the gelatine layers and ensure that the capsules do not deteriorate during storage periods.

Description

1. Technical field [0001] The invention relates to a specially prepared empty capsule of pharmaceutical auxiliary material and an empty enteric-coated capsule, in particular to a double-layer hollow capsule and a multi-layer enteric-coated empty capsule. 2. Background technology [0002] The production process of hollow capsules and enteric-coated hollow capsules currently on the market: gelatin soaked in water first, swollen and then gelatinized, food colorings of various colors are added according to different needs of users, and a certain amount of opacifying agent titanium dioxide is added, Afterwards, the capsule production line is molded by dipping in glue, dried and solidified to obtain hollow capsules that disintegrate or dissolve in the stomach to release the drug in the capsule; for enteric-coated hollow capsules, a layer of enteric-coated coating that resists gastric acid is coated on the basis of the above-mentioned hollow capsules. Coating material, which is ins...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48
Inventor 刘松林
Owner ANHUI HUANGSHAN CAPSULE CO LTD
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