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Sodium hyaluronate eyedrop containing deproteinized calf blood extractive and preparation method thereof

A sodium hyaluronate and protein removal technology, which is applied in the directions of pharmaceutical formulations, drug combinations, drug delivery, etc., to avoid microbial contamination, have broad application prospects, and reduce the probability of complications.

Inactive Publication Date: 2012-07-18
ZHAOKE PHARMA GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no preservatives that are completely non-toxic to ocular surface epithelial cells have been developed. Since artificial tears need to be used continuously, it is necessary to avoid adding bacteriostatic agents when researching ophthalmic preparations such as dry eye syndrome, or use single-dose packaging. single use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The eye drops of this embodiment include the following components:

[0045] Calf blood deproteinized extract 200ml;

[0046] Sodium Hyaluronate 10.0g;

[0047] ε-aminocaproic acid 10.0g;

[0048] Disodium Edetate 0.05g;

[0049] Sodium chloride 10.0g;

[0050] Potassium chloride 2.0g;

[0051] 1000ml water for injection.

[0052] The preparation method of the eye drops of the present embodiment adopts the following steps:

[0053] (1) Weigh 10.0 g of sodium hyaluronate, add 400 ml of water for injection to dissolve, and swell overnight to obtain a sodium hyaluronate solution;

[0054] (2) Take 200 ml of calf blood deproteinized extract, 10.0 g of ε-aminocaproic acid, 0.05 g of disodium edetate, 10.0 g of sodium chloride, and 2.0 g of potassium chloride, add 300 ml of water for injection to dissolve and mix with hyaluronic acid. Mix the sodium solution, add water for injection to the full amount and stir well;

[0055] (3) Adjust the pH of the solution obtain...

Embodiment 2

[0057] The eye drops of this embodiment include the following components:

[0058] Calf blood deproteinized extract 10 ml;

[0059] Sodium hyaluronate 0.1g;

[0060] γ-aminobutyric acid 10.0g;

[0061] Tromethamine 10.0g;

[0062] Aminotriacetic acid 1.0g;

[0063] Boric acid 1.0g;

[0064] 1000ml water for injection.

[0065] The preparation method of the eye drops of the present embodiment adopts the following steps:

[0066] (1) Weigh 0.1 g of sodium hyaluronate, add 200 ml of water for injection to dissolve, and swell overnight to obtain a sodium hyaluronate solution;

[0067] (2) Take 10 ml of calf blood deproteinized extract, 10.0 g of γ-aminobutyric acid, 10.0 g of tromethamine, 1.0 g of aminotriacetic acid, and 1.0 g of boric acid, add 200 ml of water for injection to dissolve and mix with sodium hyaluronate solution , add water for injection to the full amount and stir well;

[0068] (3) Adjust the pH of the solution obtained in step (2) to 6.0, filter and ...

Embodiment 3

[0070] The eye drops of this embodiment include the following components:

[0071] Calf blood deproteinized extract 500ml;

[0072] Sodium Hyaluronate 5.0g;

[0073] Sodium bicarbonate 1.0g;

[0074] Diethylenetriaminepentaacetic acid 1.0g;

[0075] Citric acid 1.0g;

[0076] Sodium nitrate 8.0g;

[0077] 1000ml water for injection.

[0078] The preparation method of the eye drops of the present embodiment adopts the following steps:

[0079] (1) Weigh 5.0 g of sodium hyaluronate, add 300 ml of water for injection to dissolve, and swell overnight to obtain a sodium hyaluronate solution;

[0080] (2) Take 500ml of calf blood deproteinized extract, 1.0g of sodium bicarbonate, 1.0g of diethylenetriaminepentaacetic acid, 1.0g of citric acid, and 8.0g of sodium nitrate, add 400ml of water for injection to dissolve and mix with sodium hyaluronate. Mix the solution, add water for injection to the full amount and stir well;

[0081] (3) Adjust the pH of the solution obtaine...

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Abstract

The invention discloses a sodium hyaluronate eyedrop containing deproteinized calf blood extractive. The components comprise deproteinized calf blood extractive, sodium hyaluronate, pH buffering agent, metal chelating agent, osmotic pressure regulation agent and injection water. The preparation method has the following steps: weighing the sodium hyaluronate, adding the injection water to resolve, and obtaining sodium hyaluronate solution after overnight swelling; fetching the deproteinized calf blood extractive, the pH buffering agent, the metal chelating agent and the osmotic pressure regulation agent, adding the injection water to resolve, mixing with the sodium hyaluronate solution after resolving, and agitating uniformly after supplementing the injection water to full dose; filtering and sterilizing after adjusting the pH of the solution, embedding to single dose packaging containers after being qualified by testing, and sealing and obtaining the product. The eyedrop disclosed by the invention is used for curing corneal wounds and xerophthalmia, can promote the corneal cells to incept and utilize the energy, and improves the recovery rate of the corneal wounds. The preparation method of the eyedrop avoids the stimulus to the surface cells of eyes, and prevents the contamination caused by microorganisms in tears and in air during use and storage.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a sodium hyaluronate eye drop containing deproteinized calf blood extract and a preparation method thereof. Background technique [0002] Dry eye is a common clinical ophthalmology, which is a general term for a group of diseases characterized by decreased tear secretion, decreased tear film stability and ocular surface damage. Dry eye corneal epithelium is punctately exfoliated, and fluorescein staining is positive. Since the tear film can no longer undertake its barrier, immune regulation, and mechanical removal of debris and antimicrobial effects, the cornea, which is very rich in sensory nerves, is directly exposed to the outside world. The viscous debris deposited on the conjunctival sac and the irritation of the corneal peeling epithelium rolled into filaments lead to symptoms such as dry eyes, photophobia, foreign body sensation, and visual fatigue. Th...

Claims

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Application Information

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IPC IPC(8): A61K35/14A61K9/08A61P27/04A61P27/02A61P27/06A61K31/728
Inventor 李小羿张国辉戴向荣凌娟吴艳林腾周小艳
Owner ZHAOKE PHARMA GUANGZHOU
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