Quinones derivative as well as preparation method of quinones derivative and application of quinones derivative as antibacterial agent

A technology of quinone derivatives and marine fungi, applied in the field of quinone derivatives and their preparation, can solve the problems of poor selectivity, marine natural selective antibacterial agents, etc., and achieve the effect of remarkable antibacterial activity and broad application prospects.

Active Publication Date: 2012-07-25
OCEAN UNIV OF CHINA
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Problems solved by technology

In addition, the antibacterial agents currently used are mainly broad-spectrum antibacterial preparations with poor selectivity.
In recen

Method used

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  • Quinones derivative as well as preparation method of quinones derivative and application of quinones derivative as antibacterial agent
  • Quinones derivative as well as preparation method of quinones derivative and application of quinones derivative as antibacterial agent
  • Quinones derivative as well as preparation method of quinones derivative and application of quinones derivative as antibacterial agent

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Embodiment Construction

[0011] Preparation of Compounds of the Invention

[0012] (1) The medium used for the culture of the fungus Nigrospora sp. (HM565952) contains 1.0% glucose (percentage by weight, the same below), 0.1% yeast extract, 0.2% peptone, 1.0% agar, 3% coarse sea salt, and the rest is Water, made into a test tube slant when used, and the fungal strains were cultivated at 30°C for 5 days.

[0013] The strain culture medium contains 0.1%-5.0% of glucose (percentage by weight, the same below), 0.01%-1% of yeast extract, 0.01%-1% of peptone, 0.1%-3.0% of agar, 3% of coarse sea salt, and the rest for water. (2) The fermentation medium used for the fermentation culture of the fungus Nigrospora sp. (HM565952) contains 1.0% glucose (percentage by weight, the same below), 0.1% yeast extract, 0.2% peptone, 3% coarse sea salt, and the rest is water. Cultured at 28°C for 30 days.

[0014] The fermentation medium contains 0.1%-5.0% of glucose (weight percentage, the same below), 0.01%-1% of yeas...

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Abstract

The invention relates to a quinones derivative as well as a preparation method of the quinones derivative and an application of the quinones derivative as an antibacterial agent. During the preparation, marine fungi Nigrospora sp.(HM565952) is subjected to strain culture in a culture medium, then, the marine fungi are subjected to fermentation culture in a fermentation culture medium, next, the obtained fermentation liquid is filtered, thalli are removed, and the fermentation liquid is extracted by ethyl acetate; after the extraction liquid is concentrated, chromatographic separation is carried out, and the obtained eluent is concentrated to obtain two red crystals which are respectively 4-Deoxybostrycin and Bostrycin; and acetyl oxide is added into solution in which the two compounds dissolve for reaction to obtain 3-Acetoxy-4-deoxybostrycin and 3-Acetoxy-bostrycin. The quinones derivative provided by the invention has the obvious antibacterial activity on Bacillus subtilis, Bacillus cereus, Micrococcus tetragenus, Micrococcus lutea, Staphylococcus aureus, Staphylococcus albus, Escherichia coli, Vibrio parahaemolyticus and Vibrio anguillarum and can be used for developing antibacterial agents, in addition, raw materials can be produced in large scales, and the resource limitation is avoided, so the application prospect is wide.

Description

technical field [0001] The invention relates to a quinone derivative, in particular to a quinone derivative with antibacterial effect and its preparation method and application. Background technique [0002] Bacteria can parasitize the respiratory tract, skin and navel of the human body. When they invade some parts of the human body, they can cause infections, including urinary tract infection, digestive tract infection, lung infection, wound infection, biliary tract infection, peritonitis, sepsis and meningitis, etc. , the symptoms of people after infection are stomach pain, vomiting, diarrhea and fever, and sometimes even fatal to the elderly and children with poor physique. According to the survey of disease classification from 1995 to 2007, infectious diseases accounted for 49% of the total incidence of all diseases in China, and bacterial infections accounted for 18% to 21% of all diseases. [0003] However, the resistance of bacteria is very obvious. According to the...

Claims

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Application Information

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IPC IPC(8): C07C69/21C12P7/66A61K31/222A61P31/04C12R1/645
CPCY02A50/30
Inventor 邵长伦王长云杨凯琳佘志刚
Owner OCEAN UNIV OF CHINA
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