Preparing method of paracetamol, caffein, atificial cow-bezoar and chlorphenamine maleate capsule content functional pellet

A technology of Kahuangmin capsules and contents, which can be applied in the directions of capsule delivery, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Threshold value, uneven mixing of raw materials, etc., to achieve the effect of favorable disintegration and dissolution, good drug dissolution rate and small weight difference

Inactive Publication Date: 2012-08-01
辽宁王牌速效制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantages are: mixing the raw materials and then granulating them will easily cause uneven mixing of the raw materials and make the drug components unstable; when granulating, adding auxiliary materials at the same time, especially starch, will hinder the disintegration and dissolution rate of the drug, so that the drug in the blood The concentration does not reach the threshold, and the therapeutic effect is not ideal

Method used

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  • Preparing method of paracetamol, caffein, atificial cow-bezoar and chlorphenamine maleate capsule content functional pellet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Micronize 100 kg of raw materials paracetamol, caffeine, chlorpheniramine maleate, and artificial bezoar until the particle size is 200 mesh.

[0030] 2. Preparation of API pellets

[0031] 2.1 Preparation of paracetamol instant pellets

[0032] According to the weight ratio, take 23kg of micronized acetaminophen, add 0.46kg of hydroxypropylmethylcellulose, 0.23kg of microcrystalline cellulose, 3.45kg of lactose, and 1.15kg of starch paste, mix evenly, granulate, and heat at 78°C Down drying, granulation, get particle diameter and be 22 order acetaminophen-based cores, put into the sugar-coated pan, use the mixed solution that concentration is 1% sodium carboxymethylcellulose aqueous solution and 0.308kg citric acid to do spray, Use a spray gun to spray 77kg of micronized paracetamol. When spraying the package, the temperature of the material is room temperature, the rotation speed of the sugar coating pan is 52 rpm, the air inlet temperature is 30°C, and the pressu...

Embodiment 2

[0044] 1. Micronize 100 kg of raw materials paracetamol, caffeine, chlorpheniramine maleate, and artificial bezoar until the particle size is 200 mesh.

[0045] 2. Preparation of API pellets

[0046] 2.1 Preparation of paracetamol instant pellets

[0047] According to the weight ratio, take 27kg of micronized acetaminophen, add 0.675kg of hydroxypropylmethylcellulose, 0.54kg of microcrystalline cellulose, 4.59kg of lactose, and 1.485kg of starch paste, mix evenly, and then granulate, at 82°C Drying, granulation, the particle size is 23 mesh acetaminophen-based nucleus, put into the sugar-coated pan, use the mixed solution of 1% sodium carboxymethyl cellulose aqueous solution and 0.438kg citric acid as spray, adopt Spray gun with 73kg of micronized acetaminophen, when spraying, the temperature of the material is room temperature, the rotation speed of the sugar coating pan is 52 rpm, the air inlet temperature is 40°C, the pressure of the spray gun is 0.3 MPa, and the cladding ...

Embodiment 3

[0059] 1. Micronize 100 kg of raw materials paracetamol, caffeine, chlorpheniramine maleate, and artificial bezoar until the particle size is 200 mesh.

[0060] 2. Preparation of API pellets

[0061] 2.1 Preparation of paracetamol instant pellets

[0062] According to the weight ratio, take 25kg of micronized acetaminophen, add 0.55kg of hydroxypropylmethylcellulose, 0.375kg of microcrystalline cellulose, 4kg of lactose, and 1.5kg of starch paste, mix evenly, and then granulate it. Drying, granulation, the particle diameter is 22 mesh acetaminophen-based cores, put into the sugar-coated pan, use the mixed solution of 1% sodium carboxymethyl cellulose aqueous solution and 0.375kg citric acid as spray, adopt Spray gun to spray 75kg of remaining micronized paracetamol. When spraying the package, the material temperature is room temperature, the rotation speed of the sugar coating pan is 52 rpm, the air inlet temperature is 35°C, and the spray gun pressure is 0.3MPa. The number ...

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Abstract

A preparing method of a paracetamol, caffein, atificial cow-bezoar and chlorphenamine maleate capsule content functional pellet includes: respectively performing micronization process on bulk pharmaceutical chemicals of acetaminophen, caffeine, chlorpheniramine maleate and calculus bovis factitious, taking 23%-52% of bulk pharmaceutical chemicals by weight, adding auxiliary materials into the bulk pharmaceutical chemicals to prepare a raw material primary kernel, placing the primary kernel into a sugar coating pot, and performing spraying coating on the raw material medicine primary kernel with spray and balance bulk pharmaceutical chemicals to obtain bulk pharmaceutical chemical pellets; mixing the auxiliary materials and fillers to prepare a resolving-assisting pellet; and mixing the bull pharmaceutical chemical pellets including 250mg of acetaminophen, 15mg of caffeine, 1mg of chlorpheniramine maleate and 10mg of calculus bovis factitious, and using the resolving-assisting pellet serving as the balance for filling, so that the total weight of the capsule content is 340mg. The preparing method has the advantages of: adopting micronization processing and being good in pellet liquidity, small in weight difference in a filling process and easy to fill; performing granulation separately and being capable of strengthening functions of the bulk pharmaceutical chemicals and stable in medicine composition; and being fast in disintegration and dissolving out, capable of fast achieving blood concentration of treating and good in treating effect.

Description

technical field [0001] The invention relates to a preparation method of functional pellets contained in Ankahuangmin capsules. Background technique [0002] Flu is a clinically common disease, divided into influenza and common cold. Influenza is caused by influenza virus, which exists in the patient's respiratory tract and is transmitted to others through droplets when the patient coughs or sneezes; the common cold is usually caused by a certain serotype of rhinovirus. The common cold all can fall ill all the year round, and especially season alternation, climate change can cause the incidence of a cold to rise. [0003] Ankahuangmin is a compound preparation, which is a commonly used cold medicine. Its prescription mainly consists of acetaminophen, caffeine, chlorpheniramine maleate, and artificial bezoar. Acetaminophen has analgesic and antipyretic effects. It produces analgesia by inhibiting the synthesis of prostaglandins in the central nervous system and blocking the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/48A61K9/54A61K47/38A61P11/00A61K31/167A61K31/522A61K31/4402
Inventor 马雪峰
Owner 辽宁王牌速效制药有限公司
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