High-efficiency and antibacterial polymeric micelle with high pH sensibility and biocompatibility and preparation method thereof

A technology of biocompatibility and polymer glue, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, antibacterial drugs, etc., which can solve the problem of inapplicable biomedical fields and poor antibacterial effect of polymers , poor antibacterial and antibacterial effects, etc., to achieve good bactericidal effects, improve antibacterial and bactericidal effects, and have a wide range of applications

Inactive Publication Date: 2012-10-03
TONGJI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Although the polymer prepared above has certain antibacterial and antibacterial effects, its preparation method is relatively complicated, and the antibacterial effect of the polymer is not good. areas, especially difficult to apply to the human body for a long time
[0009] In view of the poor antibacterial and antibacterial effect of the current antibacterial polymers, we propose to use the self-assembly method of amphiphilic block polymers to prepare antibacteri

Method used

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  • High-efficiency and antibacterial polymeric micelle with high pH sensibility and biocompatibility and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0033] Example 1

[0034] (1) Macromolecular initiator PEO 43 -Br synthesis

[0035] Azeotropically distill 10 g of flake PEO and 250 mL of toluene to remove excess water. The temperature of the system was lowered to room temperature, replaced with an ice water bath, and 2 mL of triethylamine and 20 mL of a toluene solution of 1.9 mL of 2-bromoisobutyryl bromide were added. The reaction is carried out for 40 hours, and the organic phase is collected by filtration, extraction, drying, filtration, precipitation, suction filtration, and vacuum drying to obtain a white powdery macroinitiator PEO 43 -Br.

[0036] (2) ATRP synthetic polymer

[0037] 1g macroinitiator PEO 43 -Br, 0.033g catalyst cuprous bromide (CuBr), 0.078g ligand bpy, 0.5g monomer diethylaminoethyl methacrylate (DEA), 2mL methanol solvent into a 50mL round bottom flask, anhydrous Atom transfer radical polymerization (ATRP) under the protection of nitrogen or argon without oxygen, temperature 60 o C, for 24h. Then add 0....

Example Embodiment

[0045] Example 2

[0046] (1) Macromolecular initiator PEO 43 -Br synthesis

[0047] Azeotropically distill 10 g of flake PEO and 250 mL of toluene to remove excess water. The temperature of the system was lowered to room temperature, replaced with an ice water bath, and 2 mL of triethylamine and 20 mL of a toluene solution of 1.9 mL of 2-bromoisobutyryl bromide were added. The reaction is carried out for 40 hours, and the organic phase is collected by filtration, extraction, drying, filtration, precipitation, suction filtration, and vacuum drying to obtain a white powdery macroinitiator PEO 43 -Br.

[0048] (2) ATRP synthetic polymer

[0049] 1g macroinitiator PEO 43 -Br, 0.033g catalyst cuprous bromide (CuBr), 0.078g ligand bpy, 0.8g monomer diethylaminoethyl methacrylate (DEA), 2mL methanol solvent was added to a 50mL round bottom flask, anhydrous Atom transfer radical polymerization (ATRP) under the protection of nitrogen or argon without oxygen, temperature 60 o C, for 30h. The...

Example Embodiment

[0054] Example 3

[0055] (1) Macromolecular initiator PEO 43 -Br synthesis

[0056] Azeotropically distill 10 g of flake PEO and 250 mL of toluene to remove excess water. The temperature of the system was lowered to room temperature, replaced with an ice water bath, and 2 mL of triethylamine and 20 mL of a toluene solution of 1.9 mL of 2-bromoisobutyryl bromide were added. The reaction is carried out for 40 hours, and the organic phase is collected by filtration, extraction, drying, filtration, precipitation, suction filtration, and vacuum drying to obtain a white powdery macroinitiator PEO 43 -Br.

[0057] (2) ATRP synthetic polymer

[0058] 1g macroinitiator PEO 43 -Br, 0.033g catalyst cuprous bromide (CuBr), 0.078g ligand bpy, 0.5g monomer diethylaminoethyl methacrylate (DEA), 2mL methanol solvent into a 50mL round bottom flask, anhydrous Atom transfer radical polymerization (ATRP) under the protection of nitrogen or argon without oxygen, temperature 60 o C, for 24h. Then add 1....

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Abstract

The invention belongs to the field of macromolecular nano biological medicine materials, and in particular relates to a high-efficiency and antibacterial polymeric micelle with high pH sensibility and biocompatibility and a preparation method thereof. An amphipathic block polymer is subjected to self-assembly by a direct dissolution method to form the micelle; and the surface of the micelle has a large number of positive charges, so that the micelle has the effects of sterilizing and inhibiting bacteria in high efficiency under the condition that other antibiotics are not added. Simultaneously, the micelle has high biocompatibility and biodegradability. The polymeric micelle has high pH sensibility, and a structure of the polymeric micelle is changed with the change of the outside pH value, and multiple medicines can be wrapped by a core-shell structure of the micelle, so the polymeric micelle has a bright application prospect.

Description

technical field [0001] The invention belongs to the field of macromolecule nano biomedical materials, and in particular relates to a pH-sensitive, biocompatible and highly effective antibacterial polymer micelle and a preparation method thereof. Background technique [0002] In recent years, with the development of polymer synthesis methods (ATRP, RAFT, NMP, ROP, click chemistry) and characterization techniques, block polymers with various structures and functions have sprung up. Due to the differences in the properties of different segments of block polymers, block polymers are widely used in many fields. One of the most important applications is that block polymers are assembled into various forms in selective solvents. Nano / micro particles are possible. The main forms of polymer assemblies found so far are: spherical micelles, rod micelles, disc-shaped micelles, spherical vesicles, bowl-shaped vesicles, multilamellar vesicles, large composite vesicles, sheets, tubes, fib...

Claims

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Application Information

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IPC IPC(8): C08F293/00C08F220/34C08G65/00C08J3/03A61K31/785A61K47/32A61P31/04
Inventor 杜建忠路航
Owner TONGJI UNIV
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