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Device and method for preparing low molecular weight water-soluble chitosan through synergy of pulsed electric field and ozone

A technology of water-soluble chitosan and pulsed electric field is applied in the field of preparation of controllable low-molecular-weight chitosan, which can solve the problems of complex fermentation process, high equipment requirements, complicated post-processing, etc., and achieves increased degradation efficiency and product purity. High effect with short preparation time

Active Publication Date: 2014-11-12
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (1) The chemical degradation method has the disadvantages of difficult control of degradation conditions, cumbersome post-processing, high cost, and low yield;
[0008] (2) The enzymatic degradation method also has problems such as the high cost of the enzyme used for degradation, the complexity of the fermentation process, and the inability to mass industrial production;
[0009] (3) Irradiation degradation is an intermittent operation, which is not conducive to continuous production, requires high equipment, and may produce toxic and harmful substances

Method used

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  • Device and method for preparing low molecular weight water-soluble chitosan through synergy of pulsed electric field and ozone
  • Device and method for preparing low molecular weight water-soluble chitosan through synergy of pulsed electric field and ozone

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Effect test

Embodiment 1

[0035] The molecular weight of high molecular weight chitosan is 3.0×10 5 Da, the degree of deacetylation is greater than 85%, mixed with the aqueous solution containing acetic acid and placed in jacketed bottle 4, wherein the volume of chitosan acidic solution is 100mL, the mass concentration of chitosan is 100g / L, the mass fraction of acetic acid solution 3%. Open the valve of oxygen cylinder 1, open ozone generator 3, the ozone concentration that ozone generator produces is controlled as 10mg / L, and ozone is passed into chitosan acidic solution by gas distributor 5 with the speed of 0.1L / min, simultaneously, Turn on the constant temperature circulator 7 to keep the chitosan acidic solution at 25°C. Use peristaltic 8 pumps (HL-4 type constant flow pump) to continuously pump the chitosan-ozone mixed solution through the air filter 6 into the pulse electric field device 9 at a flow rate of 50mL / min for circulation treatment, and adjust the electric field strength to be 20kV / cm ...

Embodiment 2

[0039] The molecular weight of high molecular weight chitosan is 5.0×10 5 Da, the degree of deacetylation is greater than 95%, and the aqueous solution containing formic acid and hydrochloric acid is mixed evenly and placed in the jacket, wherein the volume of chitosan acidic solution is 200mL, the mass concentration of chitosan is 20g / L, and the mass fraction of formic acid solution is 0.5%, and the mass fraction of hydrochloric acid is 5.0%. Open the valve of the oxygen cylinder, turn on the ozone generator, pass the 1000mg / L of ozone produced by the ozone generator into the chitosan acidic solution from the gas distributor at a speed of 1.0L / min, and at the same time, open the constant temperature circulator to make the chitosan The acidic solution was kept at 30°C. Use a continuous constant flow pump to pump the chitosan-ozone mixed solution through the air filter into the pulse electric field device at a flow rate of 10mL / min for circulation treatment, adjust the electri...

Embodiment 3

[0041] The molecular weight of high molecular weight chitosan is 6.0×10 5 Da, the degree of deacetylation is greater than 90%, and the aqueous solution containing citric acid is mixed evenly and placed in the jacket, wherein the volume of chitosan acidic solution is 400mL, the mass concentration of chitosan is 1.0g / L, the mass of citric acid solution The score is 10%. Open the valve of the oxygen cylinder, turn on the ozone generator, pass the ozone 3500mg / L produced by the ozone generator into the chitosan acid solution from the gas distributor at a speed of 3.0L / min, and at the same time, open the constant temperature circulator to make the chitosan The acidic solution was kept at 35°C. Use a continuous constant flow pump to pump the chitosan-ozone mixed solution through the air filter into the pulse electric field device at a flow rate of 120mL / min for circulation treatment, adjust the electric field strength to 5kV / cm, pulse width 110μs, pulse frequency 1500Hz, pulse wave...

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Abstract

The invention discloses a device and a method for preparing low molecular weight water-soluble chitosan through the synergy of pulsed electric field and ozone. According to the method, high molecular weight chitosan is placed into a hollow structure of a jacketed flask after dissolved in acid solution; ozone is led into high molecular weight chitosan acid solution from a gas separator; a constant temperature circulator is opened for feeding the chitosan acid solution of the ozone; degradation liquor is obtained by processing the chitosan acid solution through the pulsed electric field; and the pH of the degradation liquor is adjusted by alkali liquor, and the low molecular weight water-soluble chitosan is obtained after washing and drying. An ozone chitosan solution mixing device of the device provided by the invention mainly comprises the jacketed flask, the gas separator, an air filter, the constant temperature circulator and an exhaust collecting bottle, wherein the jacketed flask is in a hollow structure which is provided a jacket; and the gas separator and the air filter are arranged in the hollow structure of the jacketed flask. The device and the method for preparing low molecular weight water-soluble chitosan through the synergy of the pulsed electric field and the ozone has the advantages of simple process, fast degradation speed, excellent controllability of the molecular weight of the prepared water-soluble chitosan, energy saving and environmental friendliness.

Description

technical field [0001] The invention relates to a preparation method of controllable low-molecular-weight chitosan, in particular to a method for preparing low-molecular-weight water-soluble chitosan by synergistic action of high-intensity pulsed electric field and ozone. Background technique [0002] Chitin, also known as chitin, chitin, its chemical name is: (1,4)-2-acetylamino-2-deoxy-β-D-glucan. [0003] Chitosan is a product of partial or complete deacetylation of chitin, and its molecular chain consists of β-(1-4)-2-acetamido-D-glucose units and β-(1-4)-2-amino- A copolymer composed of D-glucose units has the following structural formula: [0004] [0005] Chitin and chitosan are the only basic polysaccharides in nature, and the sugar ring has active hydroxyl groups. This unique molecular structure endows chitin, chitosan and their derivatives with unique physical and chemical properties and biological activities. Such as antibacterial, lowering cholesterol, lower...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08
Inventor 韩忠曾新安孙大文
Owner SOUTH CHINA UNIV OF TECH
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