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Biomedical anti-corrosion porous compound material and preparation method thereof

A porous composite material and biomedical technology, which is applied in the field of biomedical devices, can solve the problems of reducing the ability of fracture fixation, fast degradation of magnesium alloys, and reduced mechanical strength, so as to reduce the corrosion rate and solve the problems of rapid corrosion degradation, The effect of improving toughness

Inactive Publication Date: 2015-07-08
CHONGQING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] (2) The degradation speed of magnesium alloy is fast. The biodegradation speed of magnesium alloy in the human body is too fast, and it often corrodes seriously before the fracture fixation and healing are not completely stable, and the excessive corrosion degradation speed will cause a significant decrease in mechanical strength and reduce the risk of fracture. The ability to fix, while the excessive release of magnesium ions and the high pH value triggers the excessive secretion of BMP-2, thereby activating osteoclasts, resulting in osteolysis
The invention uses porous magnesium alloy as the base to prepare composite bone repair material, and the composite material used is a polymer that can be used for bone repair. The composite bone repair material has the advantages of magnesium alloy, porous structure and polymer material, but at the same time They can overcome their respective shortcomings and have great application prospects in bone repair, but so far there are few research reports at home and abroad

Method used

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  • Biomedical anti-corrosion porous compound material and preparation method thereof
  • Biomedical anti-corrosion porous compound material and preparation method thereof
  • Biomedical anti-corrosion porous compound material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Example 1: See Figure 4-5 with Figure 7-9 , A method for preparing porous magnesium alloy medical composite material, including the following steps:

[0069] a. Preparation of porous magnesium alloy substrate by laser method

[0070] The base material is AZ31 magnesium alloy (commodity AZ31 purchased). The magnesium alloy is cut into Φ12×3 AZ31 sheets, and then a porous AZ31 base material is prepared by laser drilling. The pores are closed cells with a diameter of 100μm and a depth of pores. It is 100μm, the porosity is 30%, and finally made into porous magnesium alloy substrate;

[0071] b. Method of porous magnesium alloy pretreatment layer:

[0072] Preparation of porous magnesium alloy oxide layer: prepare 15% hydrogen peroxide, soak the porous AZ31 substrate in hydrogen peroxide at room temperature for 2 seconds to obtain an oxide layer on the surface and pores of the porous magnesium alloy;

[0073] c. Method of porous AZ31 polymer layer:

[0074] Prepare the polylactic ...

Embodiment 2

[0082] The differences between this embodiment and Embodiment 1 are as follows:

[0083] The difference in step 1) is:

[0084] a1 Take magnesium-calcium alloy and magnesium-zinc alloy to prepare as-cast ternary magnesium alloy. In the as-cast ternary magnesium alloy, in addition to magnesium, the weight of calcium and zinc accounts for 4% of the total weight of the ternary magnesium alloy; The as-cast ternary magnesium alloy prepared in step a1 is made into an extruded ternary magnesium alloy at a temperature of 300-350°C;

[0085] a2 Use a laser drilling machine to drill the extruded ternary magnesium alloy prepared by a1, with a hole diameter of 500 μm, a hole depth of 300 μm, and a porosity of 50%;

[0086] The difference in step 2) is that the prepared pretreatment layer is a phosphate layer, which is specifically as follows:

[0087] Use pure acetone to clean the porous magnesium alloy substrate prepared in step 1) until there is no impurities;

[0088] Then, the cleaned porous ma...

Embodiment 3

[0094] The differences between this embodiment and Embodiment 1 are as follows:

[0095] The difference in step 1) is:

[0096] a1. Take magnesium-calcium alloy and magnesium-strontium alloy to prepare as-cast ternary magnesium alloy. In addition to magnesium, the weight of calcium and strontium in the as-cast ternary magnesium alloy accounts for 4% of the total weight of the ternary magnesium alloy. The extruded ternary magnesium alloy is made under the condition of 300-350℃;

[0097] a2, using a laser drilling machine to perforate the extruded ternary magnesium alloy prepared by a1, the hole diameter is 700 μm, the hole depth is 400 μm, and the porosity is 55%;

[0098] The difference in step 2) is that the prepared pretreatment layer is a phosphate layer, which is specifically as follows:

[0099] First, use pure alcohol or pure acetone to clean the porous magnesium alloy substrate prepared in step 1) until it is free of impurities; soak it in a 5% sodium hydroxide solution at a tem...

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Abstract

The invention relates to a biomedical anti-corrosion porous compound material and a preparation method thereof. The porous compound material is formed by a porous magnesium alloy base body, a pre-treating layer and a polymer coating, wherein the porous magnesium alloy base body is a magnesium-zinc alloy, a magnesium-calcium alloy, a magnesium-lithium alloy, a magnesium-strontium alloy with the magnesium content of more than 90% or a ternary system alloy formed by the systems; the pore diameter of the porous magnesium alloy base body is 100-1200 microns, the depth of a closed hole is 100-500 microns and the porosity is 30-70%; the pre-treating layer is an oxidized / phosphate layer and the thickness is 1-10 microns; and the polymer coating can be a degradable and aliphatic high molecular material layer and the thickness is 5-30 microns. The preparation method comprises the following steps of: preparing the porous magnesium alloy base body, and obtaining an oxidized film, which is taken as a middle layer of the subsequent polymer coating, on the surface of the porous magnesium alloy base body and in the hole; and coating a high molecular polymer layer. According to the biomedical anti-corrosion porous compound material and the preparation method thereof, the corrosion speed of the porous magnesium alloy base body is reduced and the toughness is improved.

Description

technical field [0001] The invention relates to orthopedic internal fixation materials in medical devices, belonging to the field of biomedical devices, in particular to a biomedical corrosion-resistant porous composite material that can be used for bone repair and a preparation method thereof. Background technique [0002] The repair of bone tissue injury has always been a major problem in clinical medicine. Bone injuries caused by natural disasters, traffic accidents, industrial injuries, sports trauma, bone tumor resection, metabolic osteoporosis (OP), and congenital bone diseases have become one of the major diseases that threaten people's health. At present, metal materials still play an important role in bone repair. Compared with ceramic materials and polymer materials, metals have high mechanical strength and fracture toughness, and are suitable for use in load-bearing areas. Applied metal biomaterials include stainless steel, cobalt-based alloys, titanium and titan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10C23C22/36
Inventor 黄美娜潘复生汤爱涛彭建潘虎成王丹丹姚丹丹韩梦娇
Owner CHONGQING UNIV
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