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Method for producing ordered mesoporous bioactive microcrystal glass

A bioactive, glass-ceramic technology, applied in medical science, prosthesis, etc., to achieve the effect of simple conditions and easy operation

Inactive Publication Date: 2014-12-31
ZHEJIANG SCI-TECH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently, there are few reports on the preparation of mesoporous bioactive glass-ceramics using glass crystallization technology. Most of them use mesoporous bioactive glass and polymer materials to prepare porous bone scaffolds to improve the mechanical and biological properties of materials.

Method used

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  • Method for producing ordered mesoporous bioactive microcrystal glass
  • Method for producing ordered mesoporous bioactive microcrystal glass
  • Method for producing ordered mesoporous bioactive microcrystal glass

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1.5 grams of template agent P123 and 0.5 grams of chitosan were added and dissolved in 60 milliliters of ultrapure water, the pH value was adjusted to 1 with hydrochloric acid, and the solution was stirred until it became clear. Then add 4.25 grams of ethyl orthosilicate, 0.47 grams of triethyl phosphate, 2.97 grams of calcium nitrate, stir at 30 ° C for 3 hours, then transfer to a 100 ml reaction kettle, react at 160 ° C for 8 hours, filter and wash at 60 ° C Dry and calcinate at 550°C for 12 hours to remove the template agent, and obtain mesoporous bioactive glass-ceramic (silicon source: calcium source: phosphorus source molar ratio is 60:36:4).

Embodiment 2

[0030] Dissolve 1.5 grams of template agent P123 and 1 gram of chitosan in 50 milliliters of ultrapure water, adjust the pH value to 0.5 with hydrochloric acid, and stir the solution until it becomes clear. Then add 4.14 grams of methyl orthosilicate, 0.45 grams of trimethyl phosphate, 1.24 grams of calcium nitrate tetrahydrate, stir at 40 ° C for 5 hours, transfer to a 100 ml reaction kettle, react at 160 ° C for 15 hours, filter and wash at 60 ℃ drying, and calcining at 600 ℃ for 10 hours to remove the template agent to obtain mesoporous bioactive glass-ceramic (silicon source: calcium source: phosphorus source molar ratio is 80:15:5).

Embodiment 3

[0032] Dissolve 3 grams of template agent F127 and 0.8 grams of chitosan in 150 milliliters of ultrapure water, adjust the pH value to 0.4 with hydrochloric acid, and stir the solution until it becomes clear. Then add 19.7 grams of butyl orthosilicate, 0.98 grams of triethyl phosphate, 0.47 grams of calcium chloride, stir at 40 ° C for 5 hours, transfer to a 200 ml reaction kettle, react at 170 ° C for 8 hours, filter and wash at 60 ° C Dry and calcinate at 650°C for 8 hours to remove the template agent to obtain mesoporous bioactive glass-ceramics (the molar ratio of silicon source: calcium source: phosphorus source is 90:6:4).

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Abstract

The invention relates to a method for producing ordered mesoporous bioactive microcrystal glass. The method comprises the following steps of precursor solution preparing, hydrothermal crystallizing and organic template removing. The molar ratio of the components of the novel mesoporous bioactive glass is that silicon source to calcium source to phosphorus source is (60-90): (6-36): (4-5), the microcrystalline glass which is formed by needle-shaped hydroxyapatite nanocrystallines has a controllable mesostructure and porosity, the pore diameter can be adjusted between 2 and 30 nanometers, the specific surface area is between 300 and 500square meters / gram, and the pore volume is between 0.3 and 0.7 cubic centimeter / gram. A hydrothermal crystallization method is adopted to be combined with a template agent, and the self-assembling prepared mesoporous bioactive microcrystal glass has a simple operation process and a simple and adjustable technology as well as good biological activity, biocompatibility and certain biodegradability. The prepared novel mesoporous bioactive microcrystal material can be applied to bone repair materials of bone tissue engineering, drug release carrier materials and support materials of bone tissue engineering.

Description

technical field [0001] The invention relates to a method for preparing ordered mesoporous bioactive glass-ceramics, which belongs to the field of mesoporous materials and bone tissue engineering materials. Background technique [0002] Developing and searching for suitable bone substitute materials has always been an important topic in the field of biomedical materials science. The main component of natural bone is composed of 70% inorganic components with regular arrangement of nanometers and 30% macromolecular collagen fiber components, and its inorganic components are mainly calcium and phosphorus. Based on the concept of bionics, among the inorganic bioactive materials with the function of bone defect repair, bioactive glass is close to or similar to natural bone components, and is currently a bioactive material with many researches on bone repair and scaffold materials. The main components of bioactive glass are: silicon dioxide, calcium oxide and phosphorus pentoxide,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C03C10/02C03C11/00A61L27/10
Inventor 刘涛冯新星陈建勇赖冬志朱海霖
Owner ZHEJIANG SCI-TECH UNIV