Compound ivermectin sustained release tablet and preparation method thereof

A technology for ivermectin and sustained-release tablets, which is applied in the field of compound ivermectin sustained-release tablets and its preparation, can solve the problems of inconvenient transportation, heavy workload, and stress of animals, and achieve good therapeutic effects and functions Long-term, broad-spectrum antibacterial effect

Inactive Publication Date: 2013-02-20
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing compound preparations of ivermectin and albendazole are premixes and injections, but the premixes need to be fully mixed with the feed and fed multiple times, which requires a lot of work. Although the long-acting injections have a quick effect , but the cost is high, and it is slightly inconvenient to carry and transport, and the solvent of the injection is mostly an irritating organic solvent, which is easy to cause stress to the affected animals

Method used

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  • Compound ivermectin sustained release tablet and preparation method thereof
  • Compound ivermectin sustained release tablet and preparation method thereof
  • Compound ivermectin sustained release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prescription: ivermectin 3g, albendazole 20g, microcrystalline cellulose 40g, corn starch 60g, dextrin 53g, ethyl cellulose 20g, talcum powder 0.6g and an appropriate amount of 0.1% sodium carboxymethyl cellulose aqueous solution (made by dissolving 0.1g sodium carboxymethylcellulose in 100ml water).

[0022] Preparation method: (1) fully mix ivermectin, albendazole, corn starch, dextrin, microcrystalline cellulose and ethyl cellulose in a mixer; (2) put the mixed material into In the one-step granulator, spray 0.1% sodium carboxymethyl cellulose aqueous solution to make granules, and dry the granules at 60°C for 20 minutes; (3) add talcum powder and mix well with the granules; (4) put the granules in Tablets are made in a tablet machine.

[0023] Determination of release rate: refer to the test method of release rate in an appendix of "Veterinary Pharmacopoeia of the People's Republic of China", and the following examples are the same. The release curve of the produc...

Embodiment 2

[0025] Prescription: ivermectin 2g, albendazole 30g, lactose 50g, corn starch 60g, dextrin 20g, hypromellose 30g, PEG6000 0.6g and an appropriate amount of 2% sodium carboxymethylcellulose aqueous solution (from 100ml Add 2g carboxymethylcellulose sodium to dissolve in water and make it).

[0026] Preparation process: (1) fully mix ivermectin, albendazole, corn starch, dextrin, lactose and hypromellose in a mixer; (2) put the mixed material into a one-step In the granulator, spray 2% sodium carboxymethyl cellulose aqueous solution to make granules, and dry the granules at 60°C for 20 minutes; (3) add PEG6000 and mix well with the granules; (4) place the granules in the tablet Tablets are made in the machine.

[0027] The release curve of the product of this embodiment is shown in figure 2 , the degree of release meets the requirements.

Embodiment 3

[0029] Prescription: 10g of ivermectin, 40g of albendazole, 40g of sucrose, 60g of cornstarch, 20g of dextrin, 30g of polymethacrylate, 0.7g of magnesium stearate and an appropriate amount of 5% starch slurry (added by 100ml of water) 5g of starch is dissolved).

[0030] Preparation process: (1) fully mix ivermectin, albendazole, corn starch, dextrin, sucrose and polymethacrylate; (2) put the mixed material into a one-step granulator, Spray 5% starch slurry to make granules, and dry the granules at 60°C for 20 minutes; (3) Add magnesium stearate and mix well with the granules; (4) Put the granules in a tablet machine to make tablets .

[0031] The release curve of the product of this embodiment is shown in image 3 , the degree of release meets the requirements.

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Abstract

The invention belongs to the technical field of pharmaceutic preparation and discloses a compound ivermectin sustained release tablet and a preparation method thereof. The compound ivermectin sustained release tablet is prepared by 1 to 15 parts by weight of ivermectin, 20 to 50 parts by weight of albendazole, 110 to 153 parts by weight of diluents, 20 to 30 parts by weight of sustained-release materials, 0.5 to 0.7 part by weight of lubricating agents and an appropriate quantity of adhesion agents. The ivermectin, the albendazole, the sustained-release materials and the diluents are fully and uniformly mixed in a mixing machine to obtain a mixture, the uniformly mixed mixture is placed in a one-step granulator, the adhesion agents are sprayed to form particles, the particles are dried, the lubricating agents are added in the particles to be fully and uniformly mixed, and the particles are prepared into tablets in a tablet machine. The compound ivermectin sustained release tablet and the preparation method thereof have the advantages that the antibacterial spectrum is wide, the action time is long, the drug resistance can not be easily generated, and the curative ratio is high; compared with common compound tablets, the tablet has better therapeutic effect; and compared with simple recipe drugs, the compound ivermectin sustained release tablet has the advantages that the curative effect is remarkable, simultaneously the dosage is reduced, and the treatment costs are lowered.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a compound ivermectin sustained-release tablet and a preparation method thereof. Background technique [0002] There are many kinds of pathogens of livestock and poultry parasitic diseases, which cause huge losses to the breeding industry every year. The common ones are mainly gastrointestinal nematodes, external arthropod parasites, tapeworms and trematodes. In recent years, various diseases of livestock and poultry, including parasites The disease is becoming more and more complicated, and the mixed infection of many different types of parasites often occurs. The therapeutic effect of only one antiparasitic drug is often not satisfactory. Therefore, it is particularly important to develop compound preparations. [0003] Ivermectin is one of the results of structural modification using natural avermectin components as parent compounds, and has bec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/4184A61K9/22A61P33/00A61P33/14
Inventor 郭芳茹苑青艳杨果马志愿王菊萍
Owner 河南亚卫动物药业有限公司
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