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Water-based ultraviolet curing resin, coating based on water-based ultraviolet curing resin and medical catheter

A curing resin and water-based technology, applied in the field of hydrophilic lubricating coatings and medical catheters, can solve the problems of limited application and promotion, low adhesion of coatings, complicated modification methods, etc., and achieve good biocompatibility and not easy to fall off , easy-to-prepare effects

Active Publication Date: 2013-03-27
烟台金富士水墨有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] While surface treatment of materials, it also brings new problems, such as low adhesion of paint and easy to fall off, which also limits its application and promotion
In my country, high-end interventional medical devices are generally monopolized by foreign companies, such as Japan Terumo Co., Ltd., and the price is high
At the same time, the existing modification methods are more complicated and the production cost is higher

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] 1. Synthetic water-based UV curing resin

[0084] 1) Weigh 100 grams of polycaprolactone diol with a number-average molecular weight of 500 (about 0.2 mol in total) (brand name: PCLL205AL), raise the temperature to 30°C, and add 100.4 grams of diphenylmethane diol under nitrogen atmosphere protection and stirring. Isocyanate MDI (about 0.40mol in total) was reacted for 2.5h,

[0085] 2) Raise the temperature to 70-80°C, then add 16.0 grams of dimethylolbutyric acid DM B A (about 0.11mol in total), react for 2 hours to obtain polyurethane prepolymer A;

[0086] 3) Add 23 grams of acetone to the polyurethane prepolymer A to reduce the viscosity, then dropwise add 21.6 grams of hydroxyethyl acrylate monomer, the reaction temperature is controlled at 65 ° C, and the drop is completed in 55 minutes;

[0087] 4) temperature is lowered to room temperature, obtains polyurethane acrylate copolymer;

[0088] 5) Under stirring at room temperature, add 11.1 grams of triethylamin...

Embodiment 2

[0096] 1. Synthetic water-based UV curing resin

[0097] 1) Weigh 100 grams of polycaprolactone diol with a number-average molecular weight of 850 (about 0.12 mol in total) (brand name: PCL308), raise the temperature to 45°C, and add 98.2 grams of diphenylmethane diol under nitrogen atmosphere protection and stirring. Isocyanate MDI (about 0.39mol in total) was reacted for 2.5 h;

[0098] 2) Raise the temperature to 70-80°C, then add 14.9 grams of dimethylol butyric acid DMBA (about 0.10 mol in total), and react for 2 hours to obtain polyurethane prepolymer A;

[0099] 3) 12.5 grams of acetone was added to the polyurethane prepolymer A to reduce the viscosity, and then 49.5 grams of acrylate hydroxypropyl ester monomer was added dropwise, the reaction temperature was controlled at 65°C, and it was dropped in 55 minutes;

[0100] 4) temperature is lowered to room temperature, obtains polyurethane acrylate copolymer;

[0101] 5) Under stirring at room temperature, add 11.1 gra...

Embodiment 3

[0108] 1. Synthetic water-based UV curing resin

[0109] 1) Weigh 100 grams of polycaprolactone diol with a number average molecular weight of 1000 (about 0.1 mol in total) (brand name: PCL210N), raise the temperature to 60°C, add 64.6 grams of diphenylmethane diol under nitrogen atmosphere protection and stirring Isocyanate MDI (about 0.26mol in total) was reacted for 1.5 h;

[0110] 2) Raise the temperature to 70-80°C, then add 8.23 ​​grams of dimethylolpropionic acid DMPA (about 0.06mol in total), and react for 1.5 hours to obtain polyurethane prepolymer A;

[0111] 3) Add 18.9 grams of DMF to the polyurethane prepolymer A to reduce the viscosity, then dropwise add 24.7 grams of hydroxyethyl methacrylate monomer, the reaction temperature is controlled at 65 ° C, and the drop is completed in 50 minutes;

[0112] 4) temperature is lowered to room temperature, obtains polyurethane acrylate copolymer;

[0113] 5) Under stirring at room temperature, add 6.27 grams of triethylami...

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PUM

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Abstract

The invention discloses water-based ultraviolet curing resin, coating based on the water-based ultraviolet curing resin and a medical catheter. The water-based ultraviolet curing resin is high in tensile strength, capable of being firmly attached to polyurethane high polymer materials and good in biocompatibility. When hydrophilic lubricating coating is irradiated by ultraviolet, a urethane acrylate photoactivity low polymer, N-vinyl pyrrolidone and vinyl silicone perform free radical copolymerization reaction and perform graft polymerization with the catheter and guide wire surface which are irradiated by the ultraviolet to form a polyurethane-polyvinyl pyrrolidone (PVP)-organosilicon high-molecular polymer film. The bonding force between a film forming matter and polyurethane catheter materials is good, and the film forming matter is not liable to drop off. The coating is free of toxicity and good in biocompatibility. When the coating is in the environment having water, such as contacting with liquid, the surface of the coating quickly absorbs water to form a hydration layer, frictional resistance generated in the moving process of machines can be remarkably reduced, and the hydrophilic lubricating coating does not drop off when pipe inserting is performed.

Description

technical field [0001] The invention relates to a novel water-based UV curable resin and a hydrophilic lubricating coating compounded with the resin to prepare a medical catheter. Background technique [0002] Interventional diagnosis and treatment technology is guided by imaging equipment such as X-ray, CT and MR (nuclear magnetic resonance), using specific puncture needles, guide wires or catheters to accurately reach the lesion for diagnosis and treatment without opening human tissues. New technologies in medicine. Since the interventional instrument needs to have a lubricating surface when it enters or is pulled out of the human body and moves in the human body, so as to avoid damaging tissues in the body. [0003] As far as general materials are concerned, even if the surface is smooth and flat by precise processing, it can be found through scanning electron microscope analysis that there are still many protrusions on the surface. These protrusions not only increase th...

Claims

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Application Information

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IPC IPC(8): C08G18/76C08G18/67C08G18/42C08G18/12C09D175/14A61L29/08
Inventor 王小妹陈晓红张倩芝杨翰吴春晖
Owner 烟台金富士水墨有限公司
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