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Composite biological material capable of injecting bioglass-calcium phosphate bone cement and preparation

A technology of calcium phosphate bone cement and composite biomaterials, which is applied in the field of biomedical repair materials, can solve the problems of low mechanical properties, low HAp degradation rate, and limited bone tissue generation, and achieve high mechanical properties, stable chemical bonding, and effective Good for growth

Inactive Publication Date: 2013-06-12
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the low degradation rate of HAp, the hydration product of calcium phosphate bone cement, the limited effect of improving bone tissue formation and low mechanical properties, the purpose of the present invention is to provide a new type of injectable bioglass-calcium phosphate bone cement composite biological Materials and their preparation methods

Method used

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  • Composite biological material capable of injecting bioglass-calcium phosphate bone cement and preparation
  • Composite biological material capable of injecting bioglass-calcium phosphate bone cement and preparation
  • Composite biological material capable of injecting bioglass-calcium phosphate bone cement and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Step 1: Preparation of 45S5 bioglass

[0037] The main raw materials of 45S5 bioglass are silicon dioxide, sodium carbonate, calcium carbonate, calcium fluoride, potassium carbonate and phosphorus pentoxide. Raw material according to a certain ratio (51.20wt%SiO 2 ,3.55wt%NaCO 3 ,18.86wt%CaCO 3 ,8.19wt%CaF 2 ,7.47wt%K 2 CO 3 and 10.73wt%P 2 o 5 ) mixed evenly, melted in a high-temperature glass lift furnace at 1170°C for 40 minutes, then quickly poured into deionized water for water quenching, filtered out the bioglass and dried it in a blast drying oven at 70°C for 1 hour, and put it in an agate mortar Grinding, taking bioglass with a particle size of about 10 microns, that is, obtaining 45S5 bioglass for future use.

[0038] Step 2: Preparation of bioglass-calcium phosphate bone cement composite biomaterial

[0039] Add 45S5 bioglass to the bone cement to form a solid phase powder according to 5% of the total weight of the solid phase powder (that is, calcium...

Embodiment 2

[0043] Step 1: Same as Example 1.

[0044] Step 2: Preparation of bioglass-calcium phosphate bone cement composite biomaterial

[0045] Add 45S5 bioglass to the bone cement at 5% of the total weight of the solid powder (that is, calcium phosphate bone cement + bioglass) to form a solid phase powder. The calcium phosphate bone cement is composed of tetracalcium phosphate and anhydrous hydrogen phosphate Calcium mixed composition, the molar ratio of the two is 1:1, the average particle size is about 6 microns, and the liquid phase (solidified liquid) is 1M potassium dihydrogen phosphate and dipotassium hydrogen phosphate aqueous solution.

[0046] The ratio of the solid phase powder to the liquid phase (solidified liquid) is 3.0 g / ml to form a paste. The curing time of the obtained injectable bioglass-calcium phosphate bone cement composite biomaterial was 12±1.2 min, which indicated that increasing the solid-liquid ratio could further shorten the curing time.

[0047] Fill th...

Embodiment 3

[0049] Step 1: Same as Example 1.

[0050] Step 2: Preparation of bioglass-calcium phosphate bone cement composite biomaterial

[0051] Add 45S5 bioglass to the bone cement according to 20% of the total weight (calcium phosphate bone cement + bioglass) to form a solid phase powder. Among them, the calcium phosphate bone cement is composed of tetracalcium phosphate and anhydrous calcium hydrogen phosphate. The molar ratio of them is 1:1, and the average particle size is about 6 microns; the liquid phase (solidified liquid) is 1M potassium dihydrogen phosphate and dipotassium hydrogen phosphate aqueous solution.

[0052] The ratio of the solid phase powder to the liquid phase (solidified liquid) is 2.0 g / ml to form a paste. The resulting injectable bioglass-calcium phosphate bone cement composite biomaterial had a curing time of 21 ± 1.4 min, indicating that the addition of 20 wt% 45S5 bioglass prolongs the curing time of CPC.

[0053] Fill the reconciled paste into a stainles...

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Abstract

The invention discloses a composite biological material capable of injecting bioglass-calcium phosphate bone cement and a preparation method thereof. The prepared composite biological material capable of injecting bioglass-calcium phosphate bone cement is composed of solid phase powder and liquid phase, wherein, the liquid phase is monopotassium phosphate and dipotassium phosphate water solution which the concentration is 1M, and the ratio between the solid phase powder and the liquid phase is 2.0 g / ml-3.0 g / ml; the solid phase powder is composed of calcium phosphate bone cement and 45S4 bioglass in a mixed mode based on a weight ratio, wherein the addition of the 45S5 bioglass accounts for 5%-40% of the gross of the solid phase powder; and the calcium phosphate bone cement is composed of tetra calcium phosphate and anhydrous calcium phosphate dibasic in a mixed mode with a 1:1 molar ratio. The composite biological material capable of injecting bioglass-calcium phosphate bone cement and the preparation have the advantages of being capable of having good liquidity, higher mechanics performance, degradation rate and biological activity, offsetting the defects of single calcium phosphate cement (CPC) or the bioglass, and being used for bone defect recovery of an oral cavity, a skull facial portion and orthopedics.

Description

technical field [0001] The invention belongs to the field of biomedical repair materials, and relates to a novel injectable bioglass-calcium phosphate bone cement composite biomaterial and a preparation method thereof. The injectable bioglass-calcium phosphate bone cement composite biomaterial of the present invention has good fluidity Sex, higher mechanical properties, degradation rate and biological activity. Background technique [0002] According to statistics, there are nearly 70 million osteoporosis patients among people over 50 years old in my country, and about 1.81 million cases of new spinal compression fractures occur every year. At present, minimally invasive vertebroplasty or balloon angioplasty has become the main surgical treatment for spinal osteoporotic compression fractures. At present, most of the materials used in vertebral body or balloon angioplasty at home and abroad are non-absorbable polymethyl methacrylate bone cement (PMMA). The material has obvi...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/12A61L27/10A61L27/50A61L31/12A61L31/02A61L31/14
Inventor 雷伟吴子祥于龙李阳吴剑维修金涛臧渊刘帅程喆赵康
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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