Composite biological material capable of injecting bioglass-calcium phosphate bone cement and preparation

A technology of calcium phosphate bone cement and composite biomaterials, which is applied in the field of biomedical repair materials, can solve the problems of low mechanical properties, low HAp degradation rate, and limited bone tissue generation, and achieve high mechanical properties, stable chemical bonding, and effective Good for growth

Inactive Publication Date: 2013-06-12
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the low degradation rate of HAp, the hydration product of calcium phosphate bone cement, the limited effect of improving bone tissue formation and low mechanical prop

Method used

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  • Composite biological material capable of injecting bioglass-calcium phosphate bone cement and preparation
  • Composite biological material capable of injecting bioglass-calcium phosphate bone cement and preparation
  • Composite biological material capable of injecting bioglass-calcium phosphate bone cement and preparation

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0035] Example 1:

[0036] Step 1: Preparation of 45S5 Bioglass

[0037] The main raw materials of 45S5 bioglass are silica, sodium carbonate, calcium carbonate, calcium fluoride, potassium carbonate and phosphorus pentoxide. According to a certain proportion of raw materials (51.20wt%SiO 2 ,3.55wt%NaCO 3 ,18.86wt%CaCO 3 ,8.19wt%CaF 2 ,7.47wt%K 2 CO 3 And 10.73wt%P 2 O 5 ) After mixing uniformly, melt in a high-temperature glass elevator furnace at 1170℃ for 40 minutes, then quickly pour it into deionized water for water quenching, filter out the bioglass and place it in a 70℃ blast drying oven to dry for 1h, in an agate mortar Grind, take bioglass with a particle size of about 10 microns, and obtain 45S5 bioglass for use.

[0038] Step 2: Preparation of bioglass-calcium phosphate cement composite biomaterial

[0039] 45S5 bio-glass is added to bone cement at 5% of the total weight of the solid-phase powder (ie calcium phosphate cement + bio-glass) to form a solid-phase powder. The c...

Example Embodiment

[0042] Example 2:

[0043] Step 1: Same as Example 1.

[0044] Step 2: Preparation of bioglass-calcium phosphate cement composite biomaterial

[0045] The 45S5 bio-glass is added to the bone cement at 5% of the total weight of the solid-phase powder (ie calcium phosphate cement + bio-glass) to form a solid-phase powder. The calcium phosphate cement consists of tetracalcium phosphate and anhydrous hydrogen phosphate Calcium mixed composition, the molar ratio of the two is 1:1, the average particle size is about 6 microns, and the liquid phase (solidification liquid) is 1M potassium dihydrogen phosphate and dipotassium hydrogen phosphate aqueous solutions.

[0046] According to the ratio of the solid phase powder and the liquid phase (solidified liquid) of 3.0 g / ml, the mixture is mixed to form a paste. The curing time of the obtained injectable bioglass-calcium phosphate cement composite biomaterial is 12±1.2 min, which indicates that increasing the solid-liquid ratio can further shor...

Example Embodiment

[0048] Example 3:

[0049] Step 1: Same as Example 1.

[0050] Step 2: Preparation of bioglass-calcium phosphate cement composite biomaterial

[0051] The 45S5 bio-glass is added to the bone cement by 20% of the total weight (calcium phosphate bone cement + bio-glass) to form a solid phase powder. The calcium phosphate cement is composed of tetracalcium phosphate and anhydrous calcium hydrogen phosphate. The molar ratio is 1:1, and the average particle size is about 6 microns; the liquid phase (solidification liquid) is 1M potassium dihydrogen phosphate and dipotassium hydrogen phosphate aqueous solutions.

[0052] According to the ratio of the solid phase powder and the liquid phase (solidified liquid) of 2.0 g / ml, the mixture is mixed to form a paste. The curing time of the obtained injectable bioglass-calcium phosphate cement composite biomaterial was 21±1.4min, indicating that adding 20wt% of 45S5 bioglass prolonged the CPC curing time.

[0053] Fill the blended paste into a stain...

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Abstract

The invention discloses a composite biological material capable of injecting bioglass-calcium phosphate bone cement and a preparation method thereof. The prepared composite biological material capable of injecting bioglass-calcium phosphate bone cement is composed of solid phase powder and liquid phase, wherein, the liquid phase is monopotassium phosphate and dipotassium phosphate water solution which the concentration is 1M, and the ratio between the solid phase powder and the liquid phase is 2.0 g/ml-3.0 g/ml; the solid phase powder is composed of calcium phosphate bone cement and 45S4 bioglass in a mixed mode based on a weight ratio, wherein the addition of the 45S5 bioglass accounts for 5%-40% of the gross of the solid phase powder; and the calcium phosphate bone cement is composed of tetra calcium phosphate and anhydrous calcium phosphate dibasic in a mixed mode with a 1:1 molar ratio. The composite biological material capable of injecting bioglass-calcium phosphate bone cement and the preparation have the advantages of being capable of having good liquidity, higher mechanics performance, degradation rate and biological activity, offsetting the defects of single calcium phosphate cement (CPC) or the bioglass, and being used for bone defect recovery of an oral cavity, a skull facial portion and orthopedics.

Description

technical field [0001] The invention belongs to the field of biomedical repair materials, and relates to a novel injectable bioglass-calcium phosphate bone cement composite biomaterial and a preparation method thereof. The injectable bioglass-calcium phosphate bone cement composite biomaterial of the present invention has good fluidity Sex, higher mechanical properties, degradation rate and biological activity. Background technique [0002] According to statistics, there are nearly 70 million osteoporosis patients among people over 50 years old in my country, and about 1.81 million cases of new spinal compression fractures occur every year. At present, minimally invasive vertebroplasty or balloon angioplasty has become the main surgical treatment for spinal osteoporotic compression fractures. At present, most of the materials used in vertebral body or balloon angioplasty at home and abroad are non-absorbable polymethyl methacrylate bone cement (PMMA). The material has obvi...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/12A61L27/10A61L27/50A61L31/12A61L31/02A61L31/14
Inventor 雷伟吴子祥于龙李阳吴剑维修金涛臧渊刘帅程喆赵康
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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