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Method for preparing surface-enhanced Raman scattering (SERS) matrix

A Raman scattering matrix and surface enhancement technology, applied in Raman scattering, instruments, analytical materials, etc., to achieve uniform particle size and gap, and uniform distribution of hot spots

Inactive Publication Date: 2013-06-12
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of non-silicon-based materials has been reported, but the preparation of SERS substrates from noble metal mesoporous materials has not been reported.

Method used

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  • Method for preparing surface-enhanced Raman scattering (SERS) matrix
  • Method for preparing surface-enhanced Raman scattering (SERS) matrix
  • Method for preparing surface-enhanced Raman scattering (SERS) matrix

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]Example 1: First, weigh the molecular sieve porous silicon KIT-6 template, put it into a three-necked bottle, add n-hexane and modifier hexamethyldisilazane, the organic solvent is based on the dissolved molecular sieve template, and the molecular sieve and modifier The mass ratio is 5.18:1. After stirring evenly, reflux for 1 hour. The product after centrifugation is washed with ethanol three times to remove the organic solvent n-hexane, and dried at 80 degrees to obtain the modified template KIT-6-HMDS. Weigh the modified template, add a silver nitrate solution with a mass concentration of 11.7% into the molecular sieve template, the mass ratio of the molecular sieve template to silver nitrate is 1:1, keep stirring for 1 hour, and then put it in a dry box at 40°C Drying, the drying time is 2 days, after drying, put it into a porcelain boat and transfer it to an atmosphere furnace for calcination under the protection of argon for 2 hours, and then wash it three times wit...

Embodiment 2

[0038] Example 2: First, weigh the molecular sieve ordered mesoporous silicon OMS template, put it into a three-necked bottle, add toluene and the modifier trimethylchlorosilane, the organic solvent is based on the dissolved molecular sieve template, the quality of the molecular sieve and the modifier The ratio is 3:1. After stirring evenly, reflux for 1 hour. The product after centrifugation is washed with ethanol three times to remove the organic solvent toluene, and dried at 80 degrees to obtain the modified template ordered mesoporous silicon OMS. Weigh the modified template, add a silver nitrate solution with a mass concentration of 2% into the molecular sieve template, the mass ratio of the molecular sieve template to silver nitrate is 0.1:1, keep stirring for 1 hour, and then put it in a dry box at 40°C Drying, the drying time is 2 days, after drying, put it into a porcelain boat and transfer it to the atmosphere furnace for calcination under the protection of argon for ...

Embodiment 3

[0039] Example 3: First, weigh the molecular sieve ordered mesoporous silicon OMS template, put it into a three-necked bottle, add toluene and modifier 3-aminopropyltriethoxysilane, the organic solvent is based on dissolving the molecular sieve template, and the molecular sieve The mass ratio to the modifier is 4.13:1. After stirring evenly, reflux for 1 hour. The product after centrifugation is washed with ethanol three times to remove the organic solvent toluene, and dried at 80 degrees to obtain the modified template ordered mesoporous silicon OMS. Weigh the modified template, add a silver nitrate solution with a mass concentration of 10% to the molecular sieve template, the mass ratio of the molecular sieve template to silver nitrate is 3:1, keep stirring for 1 hour, and then put it in a dry box at 40°C Drying, the drying time is 2 days, after drying, put it into a porcelain boat and transfer it to the atmosphere furnace for calcination under the protection of argon for 2 h...

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Abstract

The invention discloses a method for preparing a surface-enhanced Raman scattering (SERS) matrix. According to the method, precious-metal inorganic salt liquid is filled in a molecular sieve template, the template is removed by using high-concentration corrosive acid or alkaline liquid after calcination or reduction, and a precious-metal mesoporous material with uniformly distributed particle size and gaps is finally obtained. The method has the advantages that the particle diameter and gap size can be effectively controlled; the particle size and the gaps are uniformly distributed, so that the quantitative research on electromagnetic coupling among particles is facilitated; and meanwhile, the repeatability of SERS detection can be improved due to the uniformity of hotspot distribution. The low-concentration molecule detection capability can be effectively increased due to high density and small gaps, so that the SERS matrix has a broad application prospect in fields of biology, chemistry, medicine, environment and the like.

Description

【Technical field】 [0001] The invention relates to a preparation method of a surface-enhanced Raman scattering matrix, in particular to a preparation method of a mesoporous precious metal array surface-enhanced Raman scattering matrix with adjustable particle size and particle gap. 【Background technique】 [0002] Raman spectroscopic detection technology has the advantages of no need to label the sample, no photobleaching, non-destructive, non-contact, and no need for complicated sample preparation techniques, etc., but the extremely small scattering cross-section largely limits its use in many applications in the field. Surface-enhanced Raman scattering (SERS) is one of the most effective methods to solve this problem, and can obtain locally up to 10 8 -10 10 The magnitude of the Raman signal enhancement effect makes Raman spectroscopy detection technology have broad application prospects in many fields such as biomolecular detection, trace analysis, and even single-molecul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65C22C1/08B22F9/24
CPCG01N21/658
Inventor 方吉祥田翠锋杨忠波
Owner XI AN JIAOTONG UNIV
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