Preparation of monodispersed magnetic fluorescent core-shell nano-microspheres

A nano-microsphere, monodisperse technology, applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problems of magnetic fluorescent microspheres, such as particle size, uniformity and poor magnetic properties, cumbersome preparation process, and easy loss of fluorescent substances , to achieve the effect of simple equipment and operation process, monodispersity and improved magnetic response

Inactive Publication Date: 2013-07-17
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main technical difficulties and problems of this magnetic fluorescence technology are as follows: 1. The preparation process is cumbersome, and the polymerization process is not easy to accurately control
2. The prepared magnetic fluoresc

Method used

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  • Preparation of monodispersed magnetic fluorescent core-shell nano-microspheres
  • Preparation of monodispersed magnetic fluorescent core-shell nano-microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: in the 100mL reactor that is equipped with condenser, add 70g acetonitrile and 10g methyl alcohol; Take by weighing 0.05g GMA (glycidyl methacrylate), 0.07g DVB (divinylbenzene) and 0.02g NVCz ( Vinyl carbazole) and 0.003g of AIBN (azobisisobutyronitrile), after shaking and dissolving, join in the reactor and mix well; 0.03g Fe 3 o 4 Add the microspheres into a 100mL reactor; gradually raise the temperature to 82°C, and polymerize for 3 hours; conduct magnetic separation on the obtained product, pour off the supernatant, add absolute ethanol to disperse by ultrasonic, and then magnetically separate; repeat this process for several times , to remove excess monomer and polymer. Vacuum drying at room temperature yields dark brown P(GMA-EGDMA-NVCz) / Fe 3 o 4 Magnetic Composite Microspheres.

[0030] After testing, the obtained magnetic P(GMA-EGDMA-NVCz) / Fe 3 o 4 The particle size of the microsphere is 750nm, the magnetic response is 38emu / g, and the magne...

Embodiment 2

[0031] Example 2: In a 100mL reactor equipped with a condenser, add 65g of acetonitrile, 10g of ethanol and 5g of acetone; weigh 0.07g of GMA (glycidyl methacrylate), 0.07g of DVB (divinylbenzene) and 0.04 gNVCz (vinyl carbazole) and 0.001g of BPO (dibenzoyl peroxide), after shaking and dissolving, add to the reactor and mix well; add 0.05g Fe 3 o 4 Add the microspheres into a 100mL reactor; gradually raise the temperature to 80°C, and polymerize for 6 hours; perform magnetic separation on the obtained product, pour off the upper layer, add absolute ethanol to disperse by ultrasonic, and then magnetically separate; repeat this process several times , to remove excess monomer and polymer. Vacuum drying at room temperature yields dark brown P(GMA-EGDMA-NVCz) / Fe 3 o 4 Magnetic Composite Microspheres.

[0032] After testing, the obtained magnetic P(GMA-EGDMA-NVCz) / Fe 3 o 4 The particle size of the microsphere is 660nm, the magnetic response is 50emu / g, and the magnetic conte...

Embodiment 3

[0033] Embodiment 3: in the 100mL reactor that is equipped with condenser, add 78g acetonitrile; Take by weighing 0.1g GMA (glycidyl methacrylate), 0.1g EGDMA (ethylene glycol dimethacrylate) and 0.05g NVCz (vinyl carbazole) and 0.005g of AIBN (azobisisobutyronitrile), after shaking and dissolving, add in the reactor and mix well; 0.07g Fe 3 o 4 Add the microspheres into a 100mL reactor; gradually raise the temperature to 85°C, and polymerize for 2.5 hours; magnetically separate the obtained product, pour off the supernatant, add absolute ethanol for ultrasonic dispersion, and then magnetically separate; repeat this process for several times to remove excess monomer and polymer. Vacuum drying at room temperature yields dark brown P(GMA-EGDMA-NVCz) / Fe 3 o 4 Magnetic Composite Microspheres.

[0034] After testing, the obtained magnetic P(GMA-EGDMA-NVCz) / Fe 3 o 4 The particle size of the microsphere is 620nm, the magnetic response is 48emu / g, and the magnetic content is 63w...

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Abstract

The invention relates to preparation of monodispersed magnetic fluorescent core-shell nano-microspheres. The nano-scale monodispersed magnetic fluorescent core-shell microspheres with high magnetic response, high magnetic content and epoxy groups on surfaces are prepared by taking monodispersed high-magnetic response Fe3O4 prepared by a solvent thermal method as cores (CN1645530), taking GMA (glycidyl methacrylate) and polymerizable fluorescent monomers NVCz (vinyl carbazole) as functional monomers, simultaneously adding a quantity of cross-linking agent monomers and performing precipitation polymerization. The nano-scale monodispersed high-crosslinked magnetic fluorescent core-shell microspheres with good magnetic response, high surface cleanliness and active groups which can act with bioactive substances are obtained.

Description

technical field [0001] The invention belongs to the technical field of organic-inorganic composite materials, and relates to the preparation of monodisperse magnetic fluorescent core-shell nanometer microspheres. Background technique [0002] At present, fluorescent materials and magnetic materials have become an important means of high-level research in the field of biomedicine due to their fluorescent and magnetic properties. With the deepening of research, a single magnetic or fluorescent material has been difficult to meet the needs of practical applications. Compared with single-functional fluorescent probes or magnetic material probes, magnetic fluorescent multifunctional nanomaterials can simultaneously realize multiple functions such as magnetic separation, target recognition, fluorescence imaging, and magnetic resonance imaging, and have broad application prospects in many fields. , such as materials science, biology and medicine and other fields. [0003] Magneti...

Claims

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Application Information

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IPC IPC(8): C08F212/36C08F222/14C08F220/32C08F226/12C08F2/44C08K3/22B01J13/14
Inventor 张秋禹马明亮辛铁军周轮伟刘瑜张和鹏张宝亮
Owner NORTHWESTERN POLYTECHNICAL UNIV
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