Substituted benzophenone and preparation method thereof

Abstract

The invention discloses substituted benzophenone and a preparation method thereof. The substituted benzophenone has a benzophenone structure, can be used as a hydrogen abstraction type photoinitiator, can be widely applied to ultraviolet light curing and other fields, and can also be used as a key intermediate to synthesize a poly-substituted fluorenone type compound. The preparation method of the substituted benzophenone, provided by the invention, is simple to operate, toxic substances are not used, an intermediate compound B and an intermediate compound A are ingeniously utilized to construct a benzhydrol structure through Grignard reaction, and the compound with the benzophenone structure is further obtained by oxidation with pyridinium chlorodichromate; the defect that synthesis methods of benzophenone type compounds in the prior art can not be widely applied is overcome.

Description

technical field

[0001] The invention belongs to the technical field of compound synthesis, and relates to a substituted benzophenone and a preparation method thereof. Background technique

[0002] Benzophenone compounds have important physical, chemical and biological properties due to the different positions, types and quantities of substituents on the benzene rings at both ends of the carbonyl group, so they are widely used in plastics, medicine, spices and electronics industries, etc. field. With the continuous deepening of natural medicine research, a variety of specific core structure chemical components have been found to have unique pharmacological activities, among which diaryl ketones are a type of natural products with special skeleton structures, and in The distribution in natural plants is also relatively concentrated, especially in plants such as Daphne, Hypericum, Garcinia and Mango. At present, the research on its biological activity mainly focuses on anti-i...

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