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Drug for treating intestinal disease and preparation method thereof

A technology for intestinal diseases and erythromycin, applied in the field of medicine, can solve the problems of gastrointestinal reactions, less dosage of action, long onset time, etc., and achieves the effect of obvious curative effect and sufficient dosage of medicine.

Inactive Publication Date: 2014-03-26
江西南昌制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the national treatment drugs are usually: compound sulfamethoxazole (compound sulfamethoxazole), pipemidic acid, gentamicin, amikacin , erythromycin, gentamicin, chloramphenicol, tetracycline, neomycin, colistin, metronidazole (metronidazole), praziquantel, nystatin, amphotericin B, many dosage forms There are two types of tablets and capsules. After oral absorption, they are mostly absorbed or degraded in the stomach, and then reach the intestines through the blood. The onset time is long and the effect is small. It is also easy to cause damage to the internal organs of the human body, and has gastrointestinal reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A medicine for treating intestinal diseases, which comprises the following raw materials in parts by weight:

[0024] Erythromycin 100 Starch 25 Dextrin 5.

[0025] It also includes the raw material magnesium stearate, the weight of which is 0.5-0.8% of the total weight of the raw materials.

[0026] A preparation method of granules for treating intestinal diseases:

[0027] Take the erythromycin, starch and dextrin in the above parts by weight, mix them evenly, add powdered sugar, granulate, dry and pack.

[0028] A preparation method of a tablet for treating intestinal diseases:

[0029] Put the erythromycin, starch, and dextrin in the above parts by weight into a tank mixer, add the starch slurry for granulation, pour it into a tray and send it to a thermal cycle oven, control the temperature at 60-70°C, and dry for 5-8 hours After the granules are dried, they are mixed together, compressed into tablets, coated, and packaged in aluminum-plastic.

[0030] A prepar...

Embodiment 2

[0033] A medicine for treating intestinal diseases, which comprises the following raw materials in parts by weight:

[0034] Erythromycin 150 Starch 35 Dextrin 10.

[0035] It also includes the raw material magnesium stearate, the weight of which is 0.5-0.8% of the total weight of the raw materials.

[0036] A preparation method of granules for treating intestinal diseases:

[0037] Take the erythromycin, starch and dextrin in the above parts by weight, mix them evenly, add powdered sugar, granulate, dry and pack.

[0038] A preparation method of a tablet for treating intestinal diseases:

[0039] Put the erythromycin, starch, and dextrin in the above parts by weight into a tank mixer, add the starch slurry for granulation, pour it into a tray and send it to a thermal cycle oven, control the temperature at 60-70°C, and dry for 5-8 hours After the granules are dried, they are mixed together, compressed into tablets, coated, and packaged in aluminum-plastic.

[0040] A prepa...

Embodiment 3

[0043] A medicine for treating intestinal diseases, which comprises the following raw materials in parts by weight:

[0044] Erythromycin 125 Starch 32 Dextrin 7.

[0045] It also includes the raw material magnesium stearate, the weight of which is 0.5-0.8% of the total weight of the raw materials.

[0046] A preparation method of granules for treating intestinal diseases:

[0047] Take the erythromycin, starch and dextrin in the above parts by weight, mix them evenly, add powdered sugar, granulate, dry and pack.

[0048] A preparation method of a tablet for treating intestinal diseases:

[0049] Put the erythromycin, starch, and dextrin in the above parts by weight into a tank mixer, add the starch slurry for granulation, pour it into a tray and send it to a thermal cycle oven, control the temperature at 60-70°C, and dry for 5-8 hours After the granules are dried, they are mixed together, compressed into tablets, coated, and packaged in aluminum-plastic.

[0050] A prepar...

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PUM

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Abstract

The invention relates to a drug for treating intestinal disease and a preparation method thereof, and belongs to the technical field of medicines. The drug is prepared by the following raw materials in parts by weight: 100-150 parts of erythrocin, 25-35 parts of starch and 5-10 parts of dextrin. According to the present market pharmacy condition, the erythrocin is selected and used as the active substance, and the situation that the erythrocin is an alkaline antibiotic which is easily damaged by the gastric acid to drop the effect and is damaged in the acid transfusion to drop the effect is considered, so that the stability of product preparations is difficult to guarantee; the drug is absorbed by the mouth instead of the stomach, so that the drug is not degraded to drop the effect when encountering the gastric juice; the drug releases the active components when directly achieving the intestines, and acts all the active components in the focus part; the drug has enough dosage and obvious curative effect, and dose not damage the liver and the stomach.

Description

technical field [0001] The invention relates to a medicine for treating intestinal diseases and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Enteritis is gastroenteritis, enteritis and colitis caused by bacteria, viruses, fungi and parasites. Clinical manifestations include nausea, vomiting, abdominal pain, diarrhea, loose watery stools or mucus, pus and bloody stools. Some patients may have fever and tenesmus, so it is also called infectious diarrhea. Enteritis can be divided into acute and chronic types according to the length of the course of the disease; according to the classification of pathogens, it can be divided into viral enteritis, enterotoxic, invasive bacterial enteritis and mixed infection. [0003] The current national treatment drugs are usually: compound sulfamethoxazole (compound sulfamethoxazole), pipemidic acid, gentamicin, amikacin, erythromycin, gentamicin, chloramphenicol, tetracycline , n...

Claims

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Application Information

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IPC IPC(8): A61K47/40A61K31/7048A61K9/16A61K9/20A61K9/48A61P1/00
Inventor 黄凤林熊建英邵青文陈颖
Owner 江西南昌制药有限公司