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Nature crocin extraction separation method and preparation for crocin blood fat reduction drug

A blood lipid-lowering drug, saffron technology, applied in the preparation of sugar derivatives, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of low raw material utilization and production efficiency, consumption of extraction, elution solvents, and active substances Structural changes and other issues to achieve the effect of low cost, good water solubility and strong permeability

Active Publication Date: 2014-03-26
WUHAN NEW GUOFENG TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The organic solvent extraction method needs a large amount of extraction solvent, the production cost is high, the recovery rate is low, and it is easy to cause the change of the structure of the active substance and the decline of the activity.
Water infiltration deer extraction method has a long extraction period and low extraction rate, so the utilization rate of raw materials and production efficiency are low
[0004] In the invention patent CN200910307800.7, the membrane system composed of microfiltration (MF), ultrafiltration (UF), nanofiltration (NF) and reverse osmosis (RO) was used to separate and purify saffron, but the water leaching method used was prolonged production cycle
In the invention patent CN201010190584.5, macroporous adsorption resin chromatography is used for secondary separation and purification of crocin, which consumes excessive extraction and elution solvents and increases costs
At present, there is no integrated process technology that integrates online membrane separation and macroporous adsorption resin column chromatography purification to prepare high-purity saffron

Method used

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  • Nature crocin extraction separation method and preparation for crocin blood fat reduction drug
  • Nature crocin extraction separation method and preparation for crocin blood fat reduction drug
  • Nature crocin extraction separation method and preparation for crocin blood fat reduction drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Take 5 kg of dried gardenia fruit, put it into the extraction tank, add 100 kg of extraction agent, cover and seal it, control the temperature at 50 ° C, and maintain 1 atmospheric pressure, stir intermittently for 5 minutes every hour, after leaching for 5 hours, filter out Add 50kg of extractant to the filtrate for the second extraction (5 hours). The two extracts are combined and filtered through a centrifuge to filter out a total of 146kg, and cooled to 30°C; Filtration, operating temperature 25°C, pressure 0.3Mpa, to obtain 130kg of filtrate; the obtained filtrate was further filtered with a polysulfone ultrafiltration membrane PS-10 with a nominal molecular weight cut-off of 10,000 Daltons, operating temperature at 25°C, pressure 0.05Mpa, to obtain 121kg of filtrate ; The filtrate is adsorbed with HP-20 macroporous adsorption resin, followed by elution with 2 times of column volume of deionized water to remove trace hydrophilic components; then eluted with 25% etha...

Embodiment 2

[0089] Take 50kg of dried gardenia fruit, 1000kg of extractant, and put it into an extraction tank, control the temperature at 55°C, stir intermittently for 10 minutes per hour, after leaching for 4 hours, filter out the filtrate, add 800kg of extractant to extract for 5 hours, two After the secondary extracts were combined, they were centrifugally filtered to remove impurities; after cooling 1750kg of filtrate to 30°C, filter it with a microfiltration membrane PP cotton with a pore size of 10μm, operating at a temperature of 30°C and a pressure of 0.5Mpa to obtain 1670kg of filtrate; filter the filtrate with a nominal molecular weight cut-off of 30,000 Dalton's roll-type polypropylene ultrafiltration membrane HPS-30 was further filtered at an operating temperature of 30°C and a pressure of 0.2Mpa to obtain 1600kg of filtrate; the filtrate was adsorbed with D-101 macroporous adsorption resin for 5 hours; Then eluted with 2000kg25% ethanol; then eluted with 500kg80% ethanol to o...

Embodiment 3

[0093] Take 30kg of dried gardenia fruit and 600kg of extraction solvent, put them into an extraction tank, control the temperature at 45°C, stir intermittently for 5 minutes per hour, after leaching for 6 hours, filter out the filtrate, then add 400kg of extraction agent to extract for 5 hours, twice After the extracts were combined, they were coarsely filtered by a centrifuge; after the filtrate 960kg was cooled to 30°C, it was filtered with a microfiltration membrane PP cotton with a pore size of 5 μm, the operating temperature was 30°C, and the pressure was 0.2Mpa to obtain a filtrate 910kg; the filtrate was filtered with a nominal molecular weight cut-off of 10000 Dalton's hollow fiber ultrafiltration membrane PS-10 is further filtered, the operating temperature is 30 ° C, and the pressure is 0.05 Mpa to obtain 870 kg of filtrate; the filtrate flows through the resin in Example 1 for 4 hours; first use 2.5 times the column volume of deionized Water elution removes impuriti...

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Abstract

The present invention particularly relates to a nature crocin extraction separation method and preparation for a crocin blood fat reduction drug. The extraction separation method comprises: carrying out cleaning and impurity removing on dried cape jasmi fruits, extracting with deionized water, filtering to removing residue, carrying out online membrane separation and concentration fusion and macroporous absorption resin chromatography purification, and finally carrying out low-temperature spray drying to prepare the crocin. According to the present invention, the key of the invention is to create the extraction agent, and the water containing a certain auxiliary solvent is adopted to extract the crocin, wherein the extraction rate can be more than 95%; the online membrane separation and concentration fusion and the macroporous absorption resin chromatography purification are integrated; the high purity crocin production method has a characteristic of low cost and is suitable for industrial expansion production; and the compounded pharmaceutical preparation has effects of significant blood fat reduction, no side effect, effective cardiovascular and cerebrovascular related disease prevention, and blood circulation promotion, and is the preferred health care drug for crowds with high blood pressure, high blood fat and high blood sugar.

Description

technical field [0001] The invention belongs to the technical field of natural product extraction and separation, and also relates to the technical field of traditional Chinese medicine preparations. The invention relates to a preparation of high-purity saffron by using Gardenia jasminoides as raw materials, and a formula of a composite preparation of saffron, ginkgo leaf extract flavonoids and grape seed extract proanthocyanidin with the function of lowering blood fat. Background technique [0002] Gardenia is a plant genus of Rubiaceae, which is widely distributed in my country and is the first batch of medicinal and edible resources promulgated by the Ministry of Health. Gardenia has the effects of protecting the liver, promoting gallbladder, lowering fat, stopping bleeding, clearing away heat, and stopping diarrhea. Gardenia contains a variety of functional components, mainly iridoids based on geniposide, carotenoids based on gardenia saffron, and phenolic acids based o...

Claims

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Application Information

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IPC IPC(8): C07H13/06C07H1/08A61K31/7024A61P3/06A61K31/352A61K31/353
Inventor 何静仁刘莉段李歌蔡小双张瑞
Owner WUHAN NEW GUOFENG TECH DEV
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