Injectable bioactive bone cement as well as preparation method and application thereof

A bioactive, bone cement technology, applied in medical science, prostheses, etc., can solve the problems that limit the wide application of PMMA bone cement, do not have bioactivity and degradation performance, burn surrounding tissues, etc., to improve biocompatibility, Promoting mineralization, good compatibility effect

Inactive Publication Date: 2014-04-02
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the wide application of PMMA bone cement in clinical practice is limited due to its lack of biological activity and degradation performance, and the heat release will burn the surrounding tissue when implanted in the body, as well as monomer toxicity.

Method used

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  • Injectable bioactive bone cement as well as preparation method and application thereof
  • Injectable bioactive bone cement as well as preparation method and application thereof
  • Injectable bioactive bone cement as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] In the first step, 5 g of P(MMA- co -MPS) powder, add a mixed solution of 90% ethanol / water and adjust the pH value of the solution to 3.5-4.0, after one hour of reaction, add 200ml of 8g hydroxyapatite suspension that has been dispersed by ultrasonic in advance and adjust the pH of the whole system pH value to 10.0, reacted overnight, the product was filtered, ultrasonically cleaned three times with tetrahydrofuran, and vacuum-dried to obtain P(MMA- co -MPS)-HA powder.

[0042] In the second step, 0.4 g of the surface-modified hydroxyapatite powder obtained in the first step is mixed with 0.6 g of PMMA powder with a molecular weight of 700,000 and sterilized to obtain the powder part of the bone cement. The liquid part of the bone cement consisted of 2ml of MMA solution dissolved with 0.03g of BPO and 14ul of DMT. The bone cement powder component and the liquid component are mixed, stirred and evenly mixed, and injected into a mold through a syringe. The hyd...

Embodiment example 3

[0048]Hemolysis rate test sample size: a cylinder with a height of 10 mm and a width of 10 mm, and the bone cement sample used is the bone cement described in Example 1.

[0049] The first step, preparation of extraction solution: After each bone cement sample was soaked in alcohol for 24 hours and sterilized, it was soaked in phosphate buffer solution (PBS) at a ratio of 0.5ml / g at 37°C for 48 hours to obtain an extraction solution.

[0050] In the second step, the HA / PMMA bone cement material PBS extraction solution, PBS (negative control) and double distilled water (positive control) were mixed with 5 parts for each group, 2ml for each tube.

[0051] In the third step, add 2mL of 2% fresh healthy human blood suspension to each tube, incubate at 37°C for 4 hours, centrifuge at 1000r / min for 5min, take 1mL of supernatant, and measure the absorbance of each sample at 540nm under a microplate reader.

[0052] The fourth step, calculation of hemolysis rate: hemol...

Embodiment example 4

[0054] Mineralization test sample size: a cylinder with a height of 5 mm and a width of 6 mm, and the bone cement sample used is the bone cement described in Example 1.

[0055] After two groups of samples were soaked in human simulated body fluid (SBF) for 3 days, the surface of the bone cement samples was washed with PBS, and after drying, the mineralization of the bone cement surface was photographed with a scanning electron microscope (SEM). Experimental results such as Figure 4 Compared with before soaking, hydroxyapatite was newly formed on the surface of the bone cement in the two groups, indicating that this bone cement is conducive to mineralization; moreover, the hydroxyapatite formed in the experimental group on the third day was significantly more than that in the control group, It shows that the mineralization performance of the experimental group is better than that of the control group.

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Abstract

The invention provides injectable bioactive bone cement which is divided into a powder part and a liquid part, wherein the powder part comprises hydroxyapatite powder subjected to surface modification, PMMA (polymethyl methacrylate) powder with high molecular weight, benzoyl peroxide, a contrast agent and hydroquinone; the liquid part comprises a dimethyl terephthalate solution and a methyl methacrylate solution. The invention further provides a preparation method and application of the injectable bioactive bone cement. The bone cement prepared by adopting the method has a solid-to-liquid ratio suitable for injection. The mechanical property of the bone cement can reach the national standard, and the biocompatibility is high.

Description

technical field [0001] The invention relates to the field of biomaterials, more specifically, to an injectable bioactive bone cement and its preparation method and application. Background technique [0002] The most prominent feature that distinguishes bone cement from other bone repair materials is that it can be shaped arbitrarily before it is fully cured, so it can be flexibly applied to various complex bone defect wounds and has strong operability. At the same time, due to the injectability of bone cement, it can minimize the area of ​​minor surgical wounds, speed up the recovery, and reduce the pain of patients. Therefore, it is often used as a filling material and scaffold material for bone tissue to play a supporting role. Indispensable one. PMMA bone cement usually consists of two parts, solid and liquid. It can be molded arbitrarily after being mixed at room temperature. After chemical reaction, it solidifies rapidly and has a certain mechanical strength after cu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/12A61L27/50
Inventor 全昌云蒋庆饶旻昱刘珍珍
Owner SUN YAT SEN UNIV
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