Injectable bioactive bone cement as well as preparation method and application thereof

Abstract

The invention provides injectable bioactive bone cement which is divided into a powder part and a liquid part, wherein the powder part comprises hydroxyapatite powder subjected to surface modification, PMMA (polymethyl methacrylate) powder with high molecular weight, benzoyl peroxide, a contrast agent and hydroquinone; the liquid part comprises a dimethyl terephthalate solution and a methyl methacrylate solution. The invention further provides a preparation method and application of the injectable bioactive bone cement. The bone cement prepared by adopting the method has a solid-to-liquid ratio suitable for injection. The mechanical property of the bone cement can reach the national standard, and the biocompatibility is high.

Description

technical field

[0001] The invention relates to the field of biomaterials, more specifically, to an injectable bioactive bone cement and its preparation method and application. Background technique

[0002] The most prominent feature that distinguishes bone cement from other bone repair materials is that it can be shaped arbitrarily before it is fully cured, so it can be flexibly applied to various complex bone defect wounds and has strong operability. At the same time, due to the injectability of bone cement, it can minimize the area of ​​minor surgical wounds, speed up the recovery, and reduce the pain of patients. Therefore, it is often used as a filling material and scaffold material for bone tissue to play a supporting role. Indispensable one. PMMA bone cement usually consists of two parts, solid and liquid. It can be molded arbitrarily after being mixed at room temperature. After chemical reaction, it solidifies rapidly and has a certain mechanical strength after cu...

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