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Silicon oxide-calcium phosphate class composite nano-filler and preparation method thereof

A nano-filler and silicon oxide technology, applied in medical science, prosthesis, etc., to achieve the effects of easy industrialization, good dispersibility, and strong modifiability

Active Publication Date: 2015-04-22
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, studies have shown that silicon apatite obtained by incorporating silicon into the lattice of HA can effectively improve the biological activity of HA, but it mainly presents the needle-like and flake-like shapes of hydroxyapatite.

Method used

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  • Silicon oxide-calcium phosphate class composite nano-filler and preparation method thereof
  • Silicon oxide-calcium phosphate class composite nano-filler and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Mix 7ml of TEOS (tetraethyl orthosilicate) and 160ml of ethanol evenly, heat up to 50°C; then mix 7ml of ammonia water, 9ml of water and 20ml of ethanol into the above mixture, and continue the reaction for 5 hours. Stop heating, then stir at room temperature for 12 hours to obtain silicon oxide alcohol sol A; adjust the pH value of A to 10 with ammonia water, add 30 ml of KH570, and mix it with 5 ml of 0.5M diammonium hydrogen phosphate solution to obtain a mixed solution B; 8.2 milliliters of calcium nitrate solutions are added dropwise to the B solution at a certain rate to obtain solution C, and are continuously stirred at a certain rate during the dropping process; after the C solution is aged for 20 hours, acetone is used to carry out multiple centrifugal separation and washing, and then The silica-hydroxyapatite composite nanoparticles were obtained by freeze-drying. Such as figure 1 and 2 Shown are TEM (transmission electron microscope photos) and XRD (X-ray d...

Embodiment 2

[0026] Mix 7ml of TEOS (tetraethyl orthosilicate) and 160ml of ethanol evenly, and heat up to 50°C; then mix 9ml of ammonia water, 9ml of water and 20ml of ethanol into the above mixture, and continue to react for 4 hours. Stop heating, then stir at room temperature for 4 hours to obtain silicon oxide alcohol sol A; adjust the pH value of A to 10 with ammonia water, add 30 ml of KH570, and mix it with 5 ml of 0.5M diammonium hydrogen phosphate solution to obtain a mixed solution B; 8.2 milliliters of calcium nitrate solutions are added dropwise to the B solution at a certain rate to obtain solution C, and are continuously stirred at a certain rate during the dropping process; after the C solution is aged for 20 hours, acetone is used to carry out multiple centrifugal separation and washing, and then The silica-hydroxyapatite composite nanoparticles were obtained by freeze-drying.

Embodiment 3

[0028] Mix 9ml of TEOS (tetraethyl tetrasilicate) and 160ml of ethanol evenly, and control the temperature at 30°C; then mix 9ml of ammonia water, 9ml of water and 20ml of ethanol into the above mixture, and continue to react for 12 hours , stop heating, and then stir at room temperature for 48 hours to obtain silicon oxide alcohol sol A; adjust the pH value of A to 5 with ammonia water, add 30 ml of KH570, mix it with 5 ml of 0.5M diammonium hydrogen phosphate solution, and obtain a mixed Solution B; 8.2 milliliters of calcium nitrate solutions are added dropwise to the B solution at a certain rate to obtain solution C, and the dripping process is continuously stirred at a certain rate; after the C solution is aged for 20 hours, ethanol is used to carry out multiple centrifugation and washing, and then Silica-calcium phosphate composite nanoparticles are obtained by freeze-drying.

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Abstract

The invention provides a silicon oxide-calcium phosphate class composite nano-filler and a preparation method thereof. Tetraethoxysilane and ethyl alcohol are evenly mixed; temperature rises to 25 DEG C TO 60 DEG C; ammonium hydroxide, water and ethyl alcohol are evenly mixed to be added into the above mixed liquor; an reaction is continuously made for 4 hours to 12 hours; heating is stopped; and stirring is carried out for 4 hours to 48 hours at the normal temperature to obtain alcosol A of silicon oxide. The pH value of the alcosol A is adjusted to range from 4 to 11; a silane coupling agent is added into the alcosol A; and the mixture is mixed with a diammonium hydrogen phosphate solution to obtain a mixed solution B. A dissoluble calcium saline solution is dropped into the solution B to obtain a solution C; stirring is carried continuously in the dropping process; aging of the solution C is carried out for 4 hours to 48 hours, repeated centrifugal separation washing is carried out with a solvent; and drying is carried out to obtain the silicon oxide-calcium phosphate class composite nano-filler. The silicon oxide-calcium phosphate class composite nano-filler is good in dispersibility, high in modificability, simple in preparation method and prone to industrialization.

Description

technical field [0001] The invention relates to a preparation method of a nano-filler commonly used in the preparation and modification of biological materials, in particular to a silicon oxide-calcium phosphate composite nano-filler and a preparation method thereof. The method belongs to the preparation technology of nanometer materials and composite materials thereof, and the prepared materials can be widely used in the fields of biology, medicine, chemical industry, materials and the like. Background technique [0002] In order to improve the mechanical properties, corrosion resistance, wear resistance and other physical properties of dental materials or bone materials, nano fillers are often added to the materials. Nano-hydroxyapatite (HA), nano-Al 2 o 3 , nano-SiO 2 , Nano TiO 2 , Nano ZrO 2 A variety of nanomaterials have been used in dental materials or bone materials to improve various physical properties of materials. Due to its low toxicity, excellent lubrica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/50
Inventor 何丹农周涓张彬杨迪诚朱君
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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