Method for preparing progesterone by taking 1,4-androstenedione as raw material

A technology of androstenedione and progesterone, which is applied in the field of preparation of progesterone, can solve the problems of large environmental pollution and restrictions, achieve low prices, low manufacturing costs, and solve the effects of resource scarcity
CN103848879AActive Publication Date: 2014-06-11HUNAN KEYUAN BIO PRODS
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HUNAN KEYUAN BIO PRODS
Publication Date
2014-06-11

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Abstract

The invention discloses a method for preparing progesterone by taking 1,4-androstenedione as a raw material, which comprises the following steps: 1) dissolving 1,4-androstenedione into an organic solvent, adding the acid of trimethyl orthoformate or triethyl orthoformate, and introducing nitrogen to protect the 1,4-androstenedione to synthesize the enol ether of 1,4-androstenedione, namely 3-methoxy-androstane 3,5-diene-20-ketone; and 2) dispersing (1-methoxy ethyl)-triphenylphosphine salt in a reaction medium, an organic solvent, adding alkali at low temperature, performing a Wittig reaction of the 3-methoxy-androstane 3,5-diene-20-ketone synthesized in the step 1), and purifying and crystallizing to obtain progesterone. By adopting the 1,4-androstenedione as the raw material, the method solves the problem that of lack in raw materials for synthesizing steroid drugs such as progesterone, and improves the utilization rate of 1,4-androstenedione and the yield of progesterone; the preparation process is simple.
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Description

technical field

[0001] The invention relates to a method for preparing progesterone, in particular to a method for preparing progesterone by using 1,4-androstenedione as a raw material. Background technique

[0002] Progesterone is a natural progestin secreted by the corpus luteum of the ovary. It has a significant morphological effect on the estrogen-stimulated endometrium in vivo and is necessary to maintain pregnancy.

[0003] Progesterone is clinically used in the reactive diagnosis of threatened abortion, habitual abortion and other amenorrhea or the cause of amenorrhea.

[0004] At present, the synthetic method of progesterone has four following synthetic methods, specifically:

[0005] (1) Synthesis of progesterone with diosgenin as raw material, the reaction equation is as follows:

[0006]

[0007] (2) Synthesis of progesterone with ergosterol as raw material, the reaction equation is as follows:

[0008]

[0009] (3) Synthesis of progesterone with stigmast...

Claims

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