Preparation method of squalene and astaxanthin composite multivesicular liposome and radical lowering and harm reducing method thereof

A multivesicular liposome and astaxanthin technology, applied in the field of chemistry, can solve the problems of hard outer wall, poor air permeability, small particle size of microcapsules, etc., and achieve the effects of increasing stability, strong air permeability and large surface area

Active Publication Date: 2014-06-18
CHINA TOBACCO GUANGXI IND +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microcapsules have small particle size, hard outer wall and poor air permeability, so they are not suitable for use in cigarette filters
[0009] The research on processing these free radical scavengers into multivesicular liposomes and putting them into cig

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Prepare each component according to the following parts by mass: 18 grams (g) of hydrogenated lecithin; Squalene (Shanghai Xinran Biotechnology Co., Ltd., the content is greater than 96.0%, and the following examples are the same. But do not limit the present invention accordingly, Those skilled in the art can adopt other sources of squalene) 5 grams (g); Astaxanthin (Jingzhou Natural Astaxanthin Co., Ltd., content is greater than 2.0%, the following examples are the same. But do not limit the present invention accordingly. , those skilled in the art can use other sources of astaxanthin) 42 grams (g); polyethylene glycol 40015 grams (g); medium molecular weight (130000 ~ 200000 Daltons) hydroxyethyl starch 20 grams (g).

[0052] The preparation steps are:

[0053] S1. Dissolve hydrogenated phospholipids, squalene and astaxanthin in 100 mL of propylene glycol to obtain a mixed system;

[0054] S2. Transfer the mixed system obtained from S1 into 50 mL of water containing...

Embodiment 2

[0059] Prepare each component according to the following parts by mass: 18 grams of hydrogenated soybean lecithin; 10 grams of squalene; 37 grams of astaxanthin; 15 grams of stearyl alcohol; 20 grams of high molecular weight (450,000-480,000 Dalton) hydroxyethyl starch .

[0060] The preparation steps are:

[0061] S1. Dissolve hydrogenated soybean lecithin, squalene and astaxanthin in 100 milliliters (mL) of propylene glycol to obtain a mixed system;

[0062] S2. Transfer the mixed system obtained from S1 into 50 mL of water containing 15 g of stearyl alcohol, and perform high-speed homogenization to make it fully mixed to obtain a homogenized mixed system;

[0063] S3. add hydroxyethyl starch to the homogenized mixing system of S2 and stir to form a stable particulate suspension;

[0064] S4. Freeze-drying the microparticle suspension obtained in S3 to obtain a multivesicular liposome containing a composition of squalene and astaxanthin.

Embodiment 3

[0066] Each component was prepared according to the following parts by mass: hydrogenated lecithin and hydrogenated soybean lecithin totaling 18 grams; 20 grams of squalene; 27 grams of astaxanthin; 15 grams of glycerol; 20 grams of starch.

[0067] The preparation steps are:

[0068] S1. Dissolve hydrogenated soybean lecithin, squalene and astaxanthin in 100 milliliters (mL) of propylene glycol to obtain a mixed system;

[0069] S2. Transfer the mixed system obtained from S1 into 50 mL of water containing 15 g of glycerol, and perform high-speed homogenization to make it fully mixed to obtain a homogenized mixed system;

[0070] S3. add hydroxyethyl starch to the homogenized mixing system of S2 and stir to form a stable particulate suspension;

[0071] S4. Freeze-drying the microparticle suspension obtained in S3 to obtain a multivesicular liposome containing a composition of squalene and astaxanthin.

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Abstract

The invention discloses a preparation method of a squalene and astaxanthin composite multivesicular liposome and a radical lowering and harm reducing method thereof. The multivesicular liposome is prepared from 12-18 parts of hydrogenated phospholipid, 10-20 parts of stabilizer, 10-15 parts of surfactant and the balance of squalene and astaxanthin composite. Through microencapsulating the squalene and astaxanthin composite, the defect that the squalene and astaxanthin composite is easily oxidized in the air and loses effectiveness is overcome, and the effect of increasing the stability of a squalene and astaxanthin blending synergy composite is achieved. The multivesicular liposome is built in a cigarette filter tip made of cellulose acetate fiber in the forming process of a cigarette filter tip bar, and 0.5-1.5g of multivesicular liposomes is arranged in each cigarette filter tip, so that a cigarette filter tip capable of lowering the harm of cigarettes is obtained; the surface area of the multivesicular liposome is large, so that anti-oxidant makes full contact with main stream smoke, gas-phase free radical in the main stream smoke can be effectively removed, and powerful technical support is provided for solving the smoking and health problem.

Description

technical field [0001] The present invention relates to the technical field of chemistry, and more particularly, to a multivesicular liposome containing a squalene and astaxanthin composition, a preparation method thereof, and an application in reducing the harm of cigarette bases. Background technique [0002] Thousands of compounds produced by smoking and the harm caused by high concentrations of free radicals to the human body have attracted widespread attention. And free radicals are the most harmful to the body, which can cause lung disease, heart disease and cancer. These free radicals can cause serious harm to smokers. Smoking produces high concentrations of free radicals, including relatively long-lived solid-phase free radicals, quinones and semiquinones, polycyclic aromatic hydrocarbon free radicals, and reactive oxygen radicals such as superoxide anion (O 2 - ), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals ( OH), singlet oxygen ( 1 O 2 ) and lipid peroxid...

Claims

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Application Information

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IPC IPC(8): A24D3/14
Inventor 张雨夏江定心陈泽鹏金亚波韦建玉刘启斌邓宾玲胡亚杰张纪利龙晓彤苏赞
Owner CHINA TOBACCO GUANGXI IND
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