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Cefpirome sulfate medicinal preparation and preparation method thereof

A technology of cefpirome sulfate and pharmaceutical preparations, which is applied in the field of medicine, can solve the problems of sodium carbonate, low basic amino acid, small adverse reactions, and slow dissolution speed, and achieve the effects of avoiding alkalosis, fast dissolution speed, and reducing procedures

Inactive Publication Date: 2014-06-25
SHANGHAI NEW ASIA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] One of the purposes of the present invention is to provide a cefpirome sulfate pharmaceutical preparation for the problems caused by the high content of anhydrous sodium carbonate in the existing cefpirome sulfate preparation, and the slow dissolution rate caused by using basic amino acids alone , to solve the above problems, the pharmaceutical preparation has lower content of sodium carbonate and basic amino acids, less adverse reactions, simple process, and more stable quality

Method used

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  • Cefpirome sulfate medicinal preparation and preparation method thereof
  • Cefpirome sulfate medicinal preparation and preparation method thereof
  • Cefpirome sulfate medicinal preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Prescription of cefpirome sulfate for injection:

[0038]

[0039] Preparation steps:

[0040] Mixed powder: pass the prescription amount of cefpirome sulfate, arginine and anhydrous sodium carbonate sterile powder through 80-mesh nylon sieve respectively, and mix the sifted sterile powder in a mixer to obtain mixed powder , measure the content of cefpirome sulfate in the mixture, determine the exact loading, and set aside.

[0041] Bottle washing: Wash the glass bottle with ultrasonic waves first, then wash it with purified water, wash it with water for injection, rinse it with compressed air, and finally put it into the oven for 2 hours of sterilization.

[0042] Washing and sterilization of rubber stoppers: Pour the rubber stoppers into the washing tank, rinse with pure water and water for injection under compressed air stirring, and then enter the oven for drying and sterilization.

[0043] Packing: After the empty bottles and rubber stoppers pass the clarity i...

Embodiment 2

[0045] Prescription of cefpirome sulfate for injection:

[0046]

[0047] Preparation steps:

[0048] Mixed powder: pass the prescription amount of cefpirome sulfate, arginine and anhydrous sodium carbonate sterile powder through 80-mesh nylon sieve respectively, and mix the sifted sterile powder in a mixer to obtain mixed powder , measure the content of cefpirome sulfate in the mixture, determine the exact loading, and set aside.

[0049] Bottle washing: Wash the glass bottle with ultrasonic waves first, then wash it with purified water, wash it with water for injection, rinse it with compressed air, and finally put it into the oven for 2 hours of sterilization.

[0050] Washing and sterilization of rubber stoppers: Pour the rubber stoppers into the washing tank, rinse with pure water and water for injection under compressed air stirring, and then enter the oven for drying and sterilization.

[0051] Subpackaging: After the empty bottle and rubber stopper pass the clarit...

Embodiment 3

[0053] Prescription of cefpirome sulfate for injection:

[0054]

[0055] Preparation steps:

[0056] Mixed powder: mix the prescribed amount of arginine and anhydrous sodium carbonate sterile powder in a mixer to prepare mixed powder A for later use.

[0057] Bottle washing: Wash the glass bottle with ultrasonic waves first, then wash it with purified water, wash it with water for injection, rinse it with compressed air, and finally put it into the oven for 2 hours of sterilization.

[0058] Washing and sterilization of rubber stoppers: Pour the rubber stoppers into the washing tank, rinse with pure water and water for injection under compressed air stirring, and then enter the oven for drying and sterilization.

[0059] Subpackage: After the empty bottle and rubber stopper pass the clarity inspection, aseptically subpackage the mixed powder A and the prescribed amount of cefpirome sulfate into a vial, cap the stopper, and crimp the cap.

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Abstract

The invention discloses a cefpirome sulfate medicinal preparation which comprises the following active ingredients: cefpirome sulfate, anhydrous sodium carbonate and alkaline amino acid, wherein according to cefpirome in cefpirome sulfate, the weight ratio of the three active ingredients is 1:(0.04-0.15):(0.3-0.8). Compared with the existing cefpirome sulfate for injection, the combined medicinal preparation is good in clarity when the preparation is dissolved, more stable in quality, simpler and more convenient in preparation technology, and capable of avoiding the alkalosis possibility and expanding the clinical usage range.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a cefpirome sulfate pharmaceutical preparation and a preparation method thereof. Background technique [0002] With the increasing application of broad-spectrum antibiotics, especially β-lactam antibiotics, the problem of bacterial resistance has become more and more important. In Gram-negative bacteria, the production of β-lactamase is the main mechanism of drug resistance. The emergence of extended-spectrum β-lactamases and inducible chromosome-mediated β-lactamases and stable derepressed mutants in intestinal Gram-negative bacilli in recent years threatens the activity of third-generation cephalosporins . Secondly, the problem of drug resistance of Gram-positive bacteria includes: Streptococcus pneumococcus viridans is resistant to penicillin and multi-drug resistance, Staphylococcus is resistant to methicillin and multi-drug resistance of Enterococcus is also a growing con...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K47/02A61K47/18A61K47/22A61P31/04
Inventor 顾惠华胡佳英张晓航郑玉林
Owner SHANGHAI NEW ASIA PHARMA
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