Purification process, comprehensive utilization method and application of ganoderma lucidum spores powder

A technology of ganoderma spore powder and ganoderma spores, which is applied in the field of preparation technology of ganoderma lucidum spore powder, can solve the problems of ganoderma spore wall system evaluation, material basis, biological activity and mechanism of action unknown, so as to improve quality and added value, and achieve sustainable The effect of sustainable development and technological science

Active Publication Date: 2014-09-03
JINHUA SHOUXIANGU PHAMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no systematic evaluation of the effect of the spore wall of Ganoderma

Method used

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  • Purification process, comprehensive utilization method and application of ganoderma lucidum spores powder
  • Purification process, comprehensive utilization method and application of ganoderma lucidum spores powder
  • Purification process, comprehensive utilization method and application of ganoderma lucidum spores powder

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0044] Example 1

[0045] The purification technology of Ganoderma lucidum spore powder is attached figure 1 As shown, the specific steps are as follows:

[0046] (1) Weigh the raw material of Ganoderma lucidum spores and pass through an 80-mesh sieve to remove larger gravel and sand;

[0047] (2) Put 2000g of sieved spores into a stirring tank, add 16000g of distilled water, stir for 20 minutes and then let stand for 15 minutes. Take out the spores and other floating impurities from the feeding port, and discharge the sludge and gravel that sink to the bottom of the water outlet at the bottom of the mixing tank. Overflow the intermediate spore suspension into the iron tank and pump it into the filter centrifuge to remove the water;

[0048] (3) The wet spores after centrifugation are put into the tray in the vacuum microwave dryer, the thickness is evenly flattened, and then dried at low temperature. Material thickness ≤4cm, temperature ≤60℃, drying to 6% water content, 1400g of dr...

Example Embodiment

[0053] Example 2

[0054] The comprehensive utilization method of Ganoderma lucidum spore powder wall shell is attached figure 2 As shown, it specifically includes the following steps:

[0055] (1) Take 1000 g of the spore powder wall shell obtained in step (5) of Example 1, and extract 3 times with 8000 g of 70% ethanol solution at 80°C for 4 hours. Combine the extracts and filter to obtain filtrate A and filter residue A. The filtrate A is concentrated under reduced pressure to recover ethanol, and freeze-drying is used to obtain 60 g of solid powder of the wall shell alcohol extract;

[0056] (2) Take 50g of the solid powder of the above-mentioned wall shell alcohol extract, add 150g of 70℃ hot water to soak for 30 minutes and stir well, then add 150g of petroleum ether and extract 3 times. After extraction, all the petroleum ether layers are combined, concentrated under reduced pressure, and freeze-dried Obtain 20 g of petroleum ether extract-like solid; the remaining aqueous l...

Example Embodiment

[0059] Example 3

[0060] The content detection of effective ingredients in refined Ganoderma lucidum spore powder and ordinary Ganoderma lucidum spore powder

[0061] Take the refined Ganoderma lucidum spore powder produced in Example 1 and the ordinary Ganoderma lucidum spore powder produced by conventional technology. The polysaccharide content and the total triterpene content were measured by the phenol-sulfuric acid method and the vanillin-glacial acetic acid-perchloric acid method. Glucose and oleanolic acid were used as controls. The absorbance of the sample was measured by spectrophotometry at 490nm and 550nm, and the corresponding concentration was calculated according to the standard curve. The results showed that the content of crude polysaccharides and total triterpenes in refined Ganoderma lucidum spore powder was significantly greater than that of ordinary Ganoderma lucidum spore powder (P<0.01), and the content was increased by nearly 20 times. The results are shown...

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Abstract

The invention discloses a purification process of ganoderma lucidum spores powder. The process comprises the following steps: removing shells of shell-broken ganoderma lucidum spores powder; after immersing by a 20-95% ethanol solution in volume fraction and water, separating shells to obtain a shell-broken ganoderma lucidum spores powder filtrate and shells of ganoderma lucidum spores powder; concentrating and drying the filtrate to obtain purified ganoderma lucidum spores powder; preparing shell alcohol extract solid powder, dichloromethane extract solid powder, ethyl acetate extract solid powder, shell aqueous extract solid powder, normal butanol extract solid powder, water phase powder or chitosan from shells of ganoderma lucidum spores powder by virtue of a comprehensive recycling process. According to the invention, ineffective component (shells) of the spores powder is separated and effective components (polysaccharide, triterpene and the like) are enriched by breaking shells and purifying, so that the content of the effective components of the purified ganoderma lucidum spores powder is remarkably improved and the effect is remarkably enhanced. The shells are comprehensively utilized, so that the economic benefit is improved.

Description

technical field [0001] The invention relates to a preparation process of ganoderma lucidum spore powder, in particular to a refining technology of ganoderma lucidum spore powder and a method for comprehensive utilization of the shell of the spore powder and its application. Background technique [0002] Ganoderma lucidum, also known as celestial grass, Shenzhi or Zhicao, is the dry fruiting body of Ganoderma lucidum (Leyss.ex Fr.) Karst or Ganoderma sinense Zhao, Xu et Zhang, a basidiomycetes Polyporaceae fungus. Its nature and taste are sweet and flat, It has the functions of strengthening the body, nourishing and strengthening, and has high medicinal value. It is widely used in my country, the Korean Peninsula, Japan, and Southeast Asian countries. When Ganoderma lucidum grows to maturity, it will eject extremely tiny oval germ cells from the gills, which are called Ganoderma lucidum spores or Ganoderma lucidum spore powder. In recent years, researchers have conducted a lo...

Claims

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Application Information

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IPC IPC(8): A61K36/074C08B37/08A23L1/29A61P35/00A61P39/06A61P1/14A61P1/00A23L33/00
Inventor 徐靖李振皓李明焱李建淼
Owner JINHUA SHOUXIANGU PHAMACEUTICAL CO LTD
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