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Preparation method of L-serine

A technology of serine and nitric acid, which is applied to the preparation of organic compounds, cyanide reaction preparation, chemical instruments and methods, etc., can solve the problems of difficult industrial production, troublesome operation, expensive enzymes, etc., so that the reaction conditions are not harsh and reduce The effect of cost and easy availability of raw materials

Active Publication Date: 2014-10-15
ZHANG JIA GANG VINSCE BIO PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has many steps, troublesome operation, and is not easy for industrial production
[0005] Journal (Yashiro, Bulletin of the chemical Society of Japan [foreign periodical] 2002 (1383)) reports that formaldehyde and glycine react to generate serine and produce by-products. It has many disadvantages. The generation of by-products affects the yield and impurities are not easy to remove
If enzymes are used to catalyze D-serine, but the price of enzymes is expensive, it is unrealistic in chemical production

Method used

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  • Preparation method of L-serine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Preparation of 2-nitro-3-chloropropionic acid

[0018] Concentrated H 2 SO 4 160-200ml in a 500ml three-necked bottle equipped with a thermometer, stir and cool down to below 0°C to control the temperature, 20ml of β-chloropropionic acid, add 60-100ml of water dropwise, and then add 40% concentrated HNO 3 10.5ml~11.5ml, react at -2~1℃ for 2~3h. After the reaction was completed, 250ml of ice-water mixture was added, and then with CH 2 Cl 2 Extract, concentrate and crystallize, and dry to obtain about 31.5 g of the product.

Embodiment 2

[0020] Preparation of 2-amino-3-chloropropionic acid

[0021] Put 30.8g of 2-nitro-3-chloropropionic acid into a 500ml airtight three-neck bottle equipped with a thermometer, dissolve it in 100-160ml of water, add 2.5g of Ni, pass a hydrogen balloon into the solution, and keep it at room temperature at 23-28°C React overnight for 12h. After the reaction was completed, filter and concentrate the crystals. After drying, about 23g of the product was obtained.

Embodiment 3

[0023] Preparation of L-serine

[0024] Prepare NaOH concentration of 2mol / L, add 20g of 2-amino-3-chloropropionic acid, put it into a 250ml three-neck bottle equipped with a thermometer, stir until dissolved, heat up to 50-55°C, stir for about 4-5 hours, and react At the end, use dilute HCl to adjust the pH value to 7.25-7.35, use electrodialysis to remove salt, and finally concentrate the water phase, crystallize, filter, dry the solid, and weigh to obtain about 16 g of the product.

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Abstract

The invention relates to a preparation method of L-serine. The method includes: taking beta-chloropropionic acid as the raw material, firstly conducting nitrification by nitric acid, then performing reduction by hydrogen, and finally carrying out hydrolysis to obtain the product. The method provided by the invention gets rid of the disadvantages of low yield of most L-serine production mainly based on biological fermentation, not many industrial production suitable methods among a lot of existing chemical synthesis methods and the like, enhances the product activity in vivo, and has short reaction route and high yield, thus being of great significance in the future industrial production and sustainable development in the market competition environment. The method mainly has the characteristics of: use of water as the solvent in a few reaction steps, safety, environmental protection and cost saving, high yield of each reaction step, simple reaction condition, short production cycle, no use of highly toxic and highly corrosive reagent, and high purity qualified product.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a preparation method of L-serine. Background technique [0002] L-serine is a non-essential amino acid, which is a non-essential amino acid. It is a sugar-producing amino acid. Serine participates in the transformation of -SH and -OH and the biosynthesis of purine and pyrimidine in the body, and can be converted into choline to form phospholipids. Phospholipids can relieve fatigue and restore physical strength, and can also be used as food and feed additives. And there are special wettability in cosmetic varieties. At present, L-serine is mainly based on biological fermentation, most of which have very low yields, and there are many chemical synthesis methods, but there are not many methods suitable for industrial production. It is very meaningful to find a simple method suitable for expanding production of. [0003] At present, many production methods re...

Claims

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Application Information

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IPC IPC(8): C07C229/22C07C227/16
Inventor 彭学东张梅赵金召黄显明
Owner ZHANG JIA GANG VINSCE BIO PHARM
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