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A method for preparing compound organic acid chelated calcium effervescent tablet with egg shell as raw material

A technology of compound calcium acid and organic acid, which is applied in the direction of drug combination, medical formula, drug delivery, etc., can solve the problems of poor effervescent effect, consumer acceptance, poor taste, etc., and achieve good effervescent effect, good taste, The effect of simple method

Inactive Publication Date: 2016-04-20
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many effervescent tablets have poor effervescent effect, tend to produce turbidity after effervescence, and have poor taste, so they are not accepted by consumers.

Method used

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  • A method for preparing compound organic acid chelated calcium effervescent tablet with egg shell as raw material
  • A method for preparing compound organic acid chelated calcium effervescent tablet with egg shell as raw material

Examples

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Effect test

Embodiment 1

[0025] A method for preparing compound organic acid chelated calcium effervescent tablets with egg shells as raw material, comprising the following steps:

[0026] (1) Take 1Kg of eggshells and clean them, put them into 15Kg of 10% sodium hydroxide solution, after the eggshell membranes float up, take out the eggshells and wash off the membranes on the eggshells with water, then put the eggshells Put it in a drying oven at 60°C for 5 hours, crush it through an 80-mesh sieve after drying, and place it in a muffle furnace for calcination at 1000°C for 2 hours to obtain eggshell powder for later use;

[0027] (2) Take 1mol of eggshell powder obtained in step (1), add 3L of distilled water, and then add 3L of organic acid mixed solution while stirring (each 15ml of organic acid mixture includes 0.08mol of citric acid and 0.03mol of gluconic acid), And put it in a constant temperature water bath at 65°C for 2 hours. After the reaction is complete, let it stand overnight. Concentrat...

Embodiment 2

[0041] A method for preparing compound organic acid chelated calcium effervescent tablets with egg shells as raw material, comprising the following steps:

[0042] (1) Take 1Kg of eggshells and clean them, put them into 15Kg of 10% sodium hydroxide solution, after the eggshell membranes float up, take out the eggshells and wash off the membranes on the eggshells with water, then put the eggshells Put it in a drying oven at 60°C for 5 hours, crush it through an 80-mesh sieve after drying, and place it in a muffle furnace for calcination at 1000°C for 2 hours to obtain eggshell powder for later use;

[0043] (2) Take 1mol of the eggshell powder obtained in step (1), add 3L of distilled water, then add 3L of organic acid mixed solution while stirring (every 15ml of organic acid mixture includes 0.07mol of lactic acid and 0.04mol of gluconic acid), and Put it in a constant temperature water bath at 60°C for 2 hours. After the reaction is complete, let it stand overnight. Concentra...

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Abstract

The invention relates to a method of preparing a composite organic acid chelated calcium effervescent tablet by adopting egg shells as a raw material. The method includes: (1) drying the egg shell and calcinating to obtain egg shell powder; (2) adding water and an organic acid mixed solution, concentrating the reaction solution, purifying and smashing to obtain composite acid calcium powder; (3) preparing raw materials; (4) uniformly stirring the composite acid calcium powder and a mixture of aqueous citric acid and tartaric acid, sieving, granulating, and drying to obtain particles I; (5) uniformly mixing sodium bicarbonate, whole milk powder and potassium sorbate, sieving, granulating and drying to obtain particles II; (6) uniformly mixing aspartame, fruit essence and sunset yellow to obtain a mixture III; and (7) uniformly mixing the particles I and the particles II to obtain a mixture IV, adding the mixture III into the mixture IV, mixing uniformly, tabletting and granulating. According to the method, active carbon is prepared by adopting the egg shell as a calcium source, the prepared effervescent tablet has characteristics of good taste, standard calcium content, stable tablets, and optimum shapes and properties, and well maintains the biological activity of the egg shell.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a method for preparing compound organic acid chelated calcium effervescent tablets using egg shells as raw materials. Background technique [0002] my country is the country with the largest production and consumption of poultry eggs in the world. With the increasing production and consumption of poultry eggs, eggshells, the unusable part, are produced in large quantities. According to the proportion of eggshells in whole eggs (generally 12% of eggs), China produces more than 4 million tons of eggshells every year, but the development and research in processing and utilization are still very weak, and the current utilization is mainly in small-scale manual production in rural areas or some scientific research units. Food processing plants and other units that consume eggs in large quantities throw eggshells into garbage bins as waste products, causing certain p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/194A61K9/46A61P3/02A23L33/00A23L2/39A61K31/191
Inventor 刘丽莉康怀彬王焕段续任广跃杨同香尹光俊
Owner HENAN UNIV OF SCI & TECH
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