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Blumea balsamifera controlled release preparation and preparation method thereof

A controlled-release preparation, the technology of Ainaxiang, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of reducing the frequency and dosage of daily dosage, reducing the daily dosage of patients, and achieving the reduction of medication The number of times, the maintenance time of promoting blood circulation and removing blood stasis, and the effect of maintaining blood drug concentration

Inactive Publication Date: 2014-11-05
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned authorized patents or published patent applications have improved the preparation of Fuxuekang products in terms of reducing the number of medications taken and expanding the dosage form. However, none of them involves reducing the number of daily doses and dosage while achieving rapid onset of effect while maintaining stable blood drug concentration.

Method used

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  • Blumea balsamifera controlled release preparation and preparation method thereof
  • Blumea balsamifera controlled release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Prescription of controlled-release Diangui Ainaxiang pellets:

[0024] Pellets containing medicine: main drug - 440g of dry paste powder of Ainaxiang yunnanensis extract; filler - 70.7g of microcrystalline cellulose, 600035.3g of polyethylene glycol;

[0025] Isolation layer: coating material - HPMCE513.1g; anti-sticking agent - talcum powder 2.9g;

[0026] Controlled release layer: controlled release coating material - EudragitNE30D40.6g; porogen - povidone K301.9g; anti-sticking agent - talc powder 16.4g;

[0027] Prescription of quick-release Diangui Ainaxiang components:

[0028] Main drug - 220g of dry paste powder of Yunnan Gui Ainaxiang extract; filler - 164g of starch-lactose complex, 119g of pregelatinized starch; disintegrating agent - 22g of croscarmellose sodium, 11g of micropowdered silica gel ;Lubricant—magnesium stearate 1.6g;

[0029] Prepare the mixed prescription quantity of the preparation:

[0030] 495.4g of controlled-release Diangui Ainaxiang p...

Embodiment 2

[0041] Prescription of controlled-release Diangui Ainaxiang pellets:

[0042] Drug-containing pellets: main drug - Diangui Ainaxiang 462g; filler - microcrystalline cellulose 111.4g;

[0043] Isolation layer: coating material - HPMCE 513.8g; anti-sticking agent - talc powder 3.1g;

[0044] Controlled-release layer: controlled-release coating materials—EudragitRS30D41.8g, EudragitRL30D1.8g; anti-sticking agent—talc powder 17.2g; plasticizer—glyceryl triacetate 3.3g;

[0045] Prescription of quick-release Diangui Ainaxiang ingredients:

[0046] Main drug—Diangui Ainaxiang 198g; filler—starch lactose complex 113g, microcrystalline cellulose 142g; disintegrant—cross-linked carmellose sodium 20g, micropowder silica gel 10g; lubricant—— Magnesium stearate 1.5g;

[0047] Prepare the mixed prescription quantity of the preparation:

[0048] 484.5g of controlled-release Diangui Ainaxiang pellets and 484.5g of quick-release Diangui Ainaxiang components, a total of 969g, were compress...

Embodiment 3

[0058] Prescription of controlled-release Diangui Ainaxiang pellets:

[0059] Drug-containing pellets: main drug - Diangui Ainaxiang 360g; filler - lactose 51g, calcium hydrogen phosphate 26g;

[0060] Isolation layer: coating material - HPMCE 58.5g; anti-sticking agent - talcum powder 5.7g;

[0061] Controlled-release layer: controlled-release coating material - 23.7g of Sulis; porogen - 2.8g of lactose;

[0062] Prescription of quick-release Diangui Ainaxiang components:

[0063] Main drug - Diangui Ainaxiang 240g; filler - starch lactose complex 222g; disintegrant - crospovidone 20g, micropowder silica gel 19g; lubricant - magnesium stearate 2.5g;

[0064] Prepare the mixed prescription quantity of the preparation:

[0065] 477.7g of controlled-release Diangui Ainaxiang pellets and 503.5g of quick-release Diangui Ainaxiang components, a total of 981.2g, were compressed into 1000 tablets.

[0066] According to the specific preparation method of the above prescription:

...

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Abstract

The invention discloses a Blumea riparia controlled release preparation and a preparation method thereof. The controlled release preparation is a preparation prepared by mixing controlled release pellets prepared by using a controlled release Blumea riparia component with a rapid release Blumea riparia component according to prescription proportions, and a mass ratio of Blumea riparia in the controlled release Blumea riparia component to Blumea riparia in the rapid release Blumea riparia component is 60:40-75:25. The preparation method of the Blumea riparia controlled release preparation comprises the following steps: 1, extracting a controlled release preparation extract dry extract powder; 2, preparing a soft material according to the controlled release Blumea riparia component; 3, preparing drug-containing pellets by using an extrusion spheronization pelletizing machine; 4, preparing the controlled release pellets through fluidized bed dressing; and 5, mixing the controlled release pellets with the rapid release component to prepare the Blumea riparia controlled release preparation. Compared with preparations in the prior art, the controlled release preparation disclosed in the invention has the advantages of administration frequency reduction, maintenance of stationary plasma concentration, prolongation of the effective menstruation hemostasis, blood circulation promotion and blood stasis removal time, side effect reduction, rapid reaching of an effective plasma concentration, safe use and deficient curative effects.

Description

technical field [0001] The invention relates to an ainaxiang controlled-release preparation and a preparation method thereof, belonging to the technical field of pharmacy. Background technique [0002] Diangui Ainaxiang, also known as Baihua Jiuliming and Huaainaxiang, is the dried whole herb of Blumea riparia (Bl.) DC. Flat in nature and light in taste, it belongs to the Liver and Spleen Channels. Diangui Ainaxiang is a Chinese herbal medicine commonly used by ethnic minorities in Southwest China. It has the effects of promoting blood circulation, removing blood stasis, stopping bleeding and regulating menstruation. The main ingredient of Fuxuekang Granules is Diangui Ainaxiang, which is recorded in the Surgical Gynecology Subvolume of the National Compilation of Chinese Patent Medicine Standards, the standard number is WS-10780(ZD-0780)-2002-2012Z, produced by Guangxi Guixi Pharmaceutical Co., Ltd. , for heavy menstrual flow and prolonged menstruation caused by blood sta...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K47/38A61K9/22A61K9/52A61P15/00
Inventor 钱一鑫康冀川王鲁
Owner GUIZHOU UNIV
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