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A kind of thiamphenicol powder dry suspension for livestock and poultry and preparation method thereof

A technology of thiamphenicol and suspension, which is applied in the field of dry suspension of thiamphenicol powder for livestock and poultry and its preparation, which can solve the problems of heavy labor and uneven mixing, so as to reduce labor and improve dispersion Sexuality, increase bioavailability effect

Active Publication Date: 2018-01-26
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, thiamphenicol is insoluble in water and can only be administered through mixing materials, which requires a lot of labor and is prone to uneven mixing.

Method used

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  • A kind of thiamphenicol powder dry suspension for livestock and poultry and preparation method thereof
  • A kind of thiamphenicol powder dry suspension for livestock and poultry and preparation method thereof
  • A kind of thiamphenicol powder dry suspension for livestock and poultry and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] A dry suspension of thiamphenicol powder for livestock and poultry, made of the following raw materials in parts by weight: 5.5 parts of thiamphenicol, 10 parts of poloxamer, 10 parts of xanthan gum, 25 parts of sodium citrate parts, 49 parts of starch, and 0.5 parts of milk essence.

[0014] The preparation method of the dry suspension of thiamphenicol powder used in livestock and poultry comprises the following steps: (1) taking by weighing thiamphenicol, poloxamer, xanthan gum, lemon Put the sodium nitrate in an oven to dry and mix uniformly to obtain the mixture, pulverize, pass through a 200-mesh sieve, and set aside; (2) mix the above-mentioned sieved mixture and starch uniformly, add 60% (volume fraction) of ethanol, granulate, and then Dry in an oven at 50°C, then add milk essence and mix well.

Embodiment 2

[0016] A dry suspension of thiamphenicol powder for livestock and poultry, made of the following raw materials in parts by weight: 5 parts of thiamphenicol, 5 parts of sodium citrate, 10 parts of hypromellose, sodium alginate 1 part, 30 parts of starch, 0.5 part of milk essence.

[0017] The preparation method of described livestock and poultry use thiamphenicol powder dry suspension, comprises the following steps: (1) take by weighing thiamphenicol, hypromellose, sodium alginate respectively according to the described weight ratio 1. Sodium citrate is placed in an oven and mixed uniformly to obtain the mixture after being dried, pulverized, and passed through a 200-mesh sieve for subsequent use; (2) mix the above-mentioned mixture and starch after sieving, add 70% (volume fraction) of ethanol, and granulate , and then put it in a 50°C oven to dry, then add milk essence and mix well.

Embodiment 3

[0019] A dry suspension of thiamphenicol powder for livestock and poultry, made of the following raw materials in parts by weight: 10 parts of thiamphenicol, 30 parts of sodium citrate, 15 parts of agar, 6010 parts of Tween, 60 parts of starch 1 part, milk essence 1 part.

[0020] The preparation method of described livestock and poultry use thiamphenicol powder dry suspension, comprises the following steps: (1) take by weighing thiamphenicol, Tween 60, agar, sodium citrate respectively according to the described weight ratio Dry in an oven and mix evenly to obtain a mixture, pulverize, pass through a 200-mesh sieve, and set aside; (2) Mix the above mixture and starch evenly, add 50% (volume fraction) of ethanol, granulate, and then place in an oven at 50°C Dry it, then add milk essence and mix well.

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PUM

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Abstract

The invention belongs to a dry suspension of thiamphenicol powder for livestock and poultry and a preparation method thereof. The dry suspension of thiamphenicol powder for livestock and poultry is made of the following raw materials in parts by weight: thiamphenicol 5~10 parts of mycin, 5~30 parts of sodium citrate, 10~15 parts of suspending agent, 1~10 parts of wetting agent, 30~60 parts of starch, 0.5~1 part of corrective agent. The beneficial effects produced by the present invention are that by adding appropriate stabilizers to thiamphenicol to make it into a dry suspension, the hydrophilicity of the drug is significantly increased, and the dispersibility of thiamphenicol in water is improved. The drug can be uniformly dispersed in water for a long time, which obviously increases the bioavailability of the drug.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparation, in particular to a dry suspension of thiamphenicol powder for livestock and poultry and a preparation method thereof. Background technique [0002] The antibacterial spectrum and antibacterial effect of thiamphenicol are similar to those of chloramphenicol, and it has a broad-spectrum antimicrobial effect, including aerobic gram-negative bacteria and gram-positive bacteria, anaerobic bacteria, rickettsia, chlamydia, and spirochetes. Thiamphenicol is bactericidal against the following bacteria: Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis. It has only antibacterial effect on the following bacteria: Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridans, Group B hemolytic streptococci, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella typhi, Anaerobic bacteria such as Salmonella paratyphi, Shigella, and Bacteroi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/165A61K47/12A61P31/04A61P31/00
Inventor 赖登明张遂平郭芳茹杨慧敏吴胜耀王书丽杨果闫树森王菊萍王黎明
Owner 河南亚卫动物药业有限公司