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Serum phosphate adsorbing agent and preparation method thereof and adsorption column for blood perfusion

An adsorbent and blood phosphorus technology, applied in the medical field, can solve the problem of inability to directly remove phosphorus, and achieve the effect of reducing pain

Active Publication Date: 2015-01-07
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

③Magnesium preparations: Oral administration of magnesium acetate can control the blood phosphorus concentration in the normal range for a long time, and hypermagnesemia will not occur, but large doses of magnesium salts can cause diarrhea
However, these methods all use drugs to indirectly bind phosphorus in the blood, and cannot achieve the purpose of directly removing phosphorus in the blood.

Method used

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  • Serum phosphate adsorbing agent and preparation method thereof and adsorption column for blood perfusion
  • Serum phosphate adsorbing agent and preparation method thereof and adsorption column for blood perfusion
  • Serum phosphate adsorbing agent and preparation method thereof and adsorption column for blood perfusion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. Synthesis of Hydroxyethylacetamide

[0045] Add 40g of toluene to a three-neck flask equipped with a constant pressure funnel and a stirrer, add 1g of ethanolamine, 3g of 10wt% sodium carbonate solution, add 2g of chloroacetyl chloride dropwise at 20-30°C, and keep stirring at 30°C for 3h. Wherein toluene is a solvent, and ethanolamine and sodium carbonate solution are reaction accelerators. The sodium carbonate solution in the present embodiment can also be replaced with solutions such as sodium bicarbonate, potassium bicarbonate, potassium carbonate. After the reaction is completed, stir and cool, filter, and dry to obtain the product glycolic acid amide:

[0046]

[0047] 2. Carrier grafting reaction

[0048] Add 5g of anhydrous potassium carbonate to a 100mL three-necked flask, then add 50g of N,N-dimethylformamide and 10g of acetone mixed solution, then add 1g of agarose microspheres and 0.05g of tetrabutylammonium bromide, 2g steps The hydroxyethylacetami...

Embodiment 2

[0061] 1. Synthesis of Hydroxyethylacetamide

[0062] Add 100g of toluene to a three-necked flask equipped with a constant pressure funnel and a stirrer, add 8g of ethanolamine, 7g of 10wt% sodium carbonate solution, drop 18g of chloroacetyl chloride at 20-30°C, and keep stirring at 30°C for 6h. After the reaction is completed, stir and cool, filter, and dry to obtain the product glycolic acid amide:

[0063]

[0064] 2. Carrier grafting reaction

[0065] Add 25g of anhydrous potassium carbonate to a 250mL three-necked flask, then add 90g of N,N-dimethylformamide and 50g of acetone mixed solution, then add 5g of cellulose microspheres and 0.15g of tetrabutylammonium bromide, 5g steps The hydroxyethylacetamide synthesized in 1 was reacted at room temperature for 24 hours. After the reaction was completed, the acetone was distilled off, washed with water and saturated saline, and N,N-dimethylformamide was washed with ethanol:

[0066]

[0067] S is a hydrophilic carrier,...

Embodiment 3

[0077] 1. Synthesis of Hydroxyethylacetamide

[0078] Add 60g of toluene to a three-necked flask equipped with a constant pressure funnel and a stirrer, add 3g of ethanolamine, 3g of 10wt% sodium carbonate solution, drop 8g of chloroacetyl chloride at 20-30°C, and keep stirring at 30°C for 4h. After the reaction is completed, stir and cool, filter, and dry to obtain the product glycolic acid amide:

[0079]

[0080] 2. Carrier grafting reaction

[0081] Add 10g of anhydrous potassium carbonate to a 250mL three-necked flask, then add 60g of N,N-dimethylformamide and 30g of acetone mixed solution, then add 3g of polyvinyl alcohol microspheres and 0.1g of tetrabutylammonium bromide, 3g The hydroxyethylacetamide synthesized in step 1 was reacted at room temperature for 16 hours. After the reaction was completed, the acetone was distilled off, washed with water and saturated saline, and N,N-dimethylformamide was washed with ethanol:

[0082]

[0083] S is a hydrophilic carr...

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Abstract

The invention provides a serum phosphate adsorbing agent; a hydrophilic carrier is immobilized by ligands capable of capturing phosphate ions to obtain the serum phosphate adsorbing agent; the hydrophilic carrier is selected from one or more out of cellulose, agarose and polyvinyl alcohol microsphere, and the ligands capable of capturing phosphate ions refer to amino polymers. The invention also provides a preparation method of the serum phosphate adsorbing agent and an adsorption column for blood perfusion, prepared by the serum phosphate adsorbing agent. Compared with medicines which are orally taken to act on the human body, the serum phosphate adsorbing agent can directly remove the phosphate ions in blood through blood circulation, so as to immediately alleviate the illness state of a patient; and the serum phosphate adsorbing agent can be combined with hemodialysis, oral taking pain of the patient each day can be reduced, and the result caused by a situation that the patient forgets to take the medicine can be avoided.

Description

technical field [0001] The invention relates to the medical field, in particular to a blood phosphorus adsorbent, a preparation method thereof, and an adsorption column for hemoperfusion. Background technique [0002] Phosphorus, as one of the basic substances of the human body, participates in the composition of many important tissues of the living body, the energy metabolism of the body, the regulation of the activity of biological macromolecules, and the regulation of acid-base balance. In a normal human body, 85% of phosphorus exists in bones and teeth, 14.9% exists in cells, and a very small part exists in plasma. Plasma phosphorus concentration is related to diet, age, and gender. Normal plasma phosphorus fluctuates between 2.5-4.5mg / dl (0.81-1.45mmol / L). The daily phosphorus intake of normal people is about 1g, and 60%-70% is absorbed by the small intestine. Free phosphorus in the plasma can be filtered out by the glomerulus, and 80% to 90% of the filtered phosphoru...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30A61M1/14
CPCA61M1/14A61M1/3687A61M1/38B01J20/265B01J20/3085B01J2220/58
Inventor 董凡房玉庆
Owner JAFRON BIOMEDICAL
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