Anti-inflammatory analgesic ointment and preparation method thereof

A technology of anti-inflammatory analgesic ointment and peppermint oil, which is applied in the direction of anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., and can solve the limitations of clinical application of anti-inflammatory analgesic ointment, wound patients cannot use, skin irritation and allergies Sexuality and other issues, to achieve the effect of no skin allergies, large drug loading, and high bioavailability

Inactive Publication Date: 2015-04-22
GUIZHOU BAIHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing method of producing anti-inflammatory and analgesic plaster generally adopts the method on the drug standard (WS3-B-1614-93). The preparation recorded in the above-mentioned standard is a rubber plaster, and the rubber plaster made by the above-mentioned method is prone to pain when peeled off , has a certain irritation and allergy to the skin, especially for patients with wounds, it cannot be used. The above shortcomings limit the clinical application of anti-inflammatory and analgesic ointment

Method used

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  • Anti-inflammatory analgesic ointment and preparation method thereof
  • Anti-inflammatory analgesic ointment and preparation method thereof
  • Anti-inflammatory analgesic ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Prescription: 120g of peppermint oil, 30g of thymol, 50g of methyl salicylate, 80g of borneol, 20g of diphenhydramine hydrochloride, 70g of belladonna liquid extract, 60g of camphor, 620g of glycerin, 98g of carbomer, carboxymethyl Sodium cellulose 33g, gum arabic 49g, sodium bicarbonate 8g, purified water 489g.

[0088] Process:

[0089] ① Grind borneol, thymol, and camphor, mix with methyl salicylate, and stir well;

[0090] ② Mix the solution in step ① with belladonna liquid extract;

[0091] ③ Pour the sodium carbonate into purified water to dissolve, pour the gelatin into the aqueous solution of sodium carbonate, and swell naturally in a water bath at 50°C;

[0092] ④ Mix carbomer, sodium carboxymethylcellulose and glycerin, pour into the mixture in step ②, and stir;

[0093] ⑤ Add the solution of step ③ and step ④ together with peppermint oil and stir evenly to obtain a colloid, paste it, cut it into sections, cover it with lining, slice it, and pack it.

[00...

Embodiment 2

[0096] Prescription: 80g of peppermint oil, 15g of thymol, 50g of methyl salicylate, 80g of borneol, 20g of diphenhydramine hydrochloride, 70g of belladonna fluid extract, 60g of camphor, 620g of glycerin, 98g of carbomer, carboxymethyl Sodium cellulose 33g, gum arabic 49g, sodium bicarbonate 8g, purified water 489g.

[0097] Process:

[0098] ① Grind borneol, thymol, and camphor, mix with methyl salicylate, and stir well;

[0099] ② Mix the solution in step ① with belladonna liquid extract;

[0100] ③ Pour the sodium carbonate into purified water to dissolve, pour the gelatin into the aqueous solution of sodium carbonate, and swell naturally in a water bath at 50°C;

[0101] ④ Mix carbomer, sodium carboxymethylcellulose and glycerin, pour into the mixture in step ②, and stir;

[0102] ⑤ Add the solution of step ③ and step ④ together with peppermint oil and stir evenly to obtain a colloid, paste it, cut it into sections, cover it with lining, slice it, and pack it.

[0103...

Embodiment 3

[0105] Prescription: 140g of peppermint oil, 30g of thymol, 80g of methyl salicylate, 80g of borneol, 20g of diphenhydramine hydrochloride, 70g of belladonna fluid extract, 40g of camphor, 620g of glycerin, 98g of carbomer, carboxymethyl Sodium cellulose 33g, gum arabic 49g, sodium bicarbonate 8g, purified water 489g.

[0106] Process:

[0107] ① Grind borneol, thymol, and camphor, mix with methyl salicylate, and stir well;

[0108] ② Mix the solution in step ① with belladonna liquid extract;

[0109] ③ Pour the sodium carbonate into purified water to dissolve, pour the gelatin into the aqueous solution of sodium carbonate, and swell naturally in a water bath at 50°C;

[0110] ④ Mix carbomer, sodium carboxymethylcellulose and glycerin, pour into the mixture in step ②, and stir;

[0111] ⑤ Add the solution of step ③ and step ④ together with peppermint oil and stir evenly to obtain a colloid, paste it, cut it into sections, cover it with lining, slice it, and pack it.

[011...

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Abstract

The invention discloses an anti-inflammatory analgesic ointment. The ointment is cataplasm prepared from oleum menthae, thymol, methyl salicylate, borneol, diphenhydramine hydrochloride, belladonna liquid extract, camphor, glycerinum, carbomer, sodium carboxymethylcellulose, arabic gum, sodium bicarbonate and pure water. The cataplasm is prepared by mixing water-soluble high-molecular compound serving as a matrix with traditional Chinese medicinal extracts; the compatibility and affinity of the cataplasm with skin can be improved, and the transdermal absorption can be improved. The anti-inflammatory analgesic ointment has the advantages of large drug loading amount, high bioavailability, long moistening period, strong sweat resistance, repeatable peeling, small irritation and skin allergy prevention.

Description

technical field [0001] The invention relates to an anti-inflammatory analgesic ointment and a preparation method thereof, belonging to the field of pharmaceutical technology. Background technique [0002] In the southern region of my country, there are many patients suffering from rheumatoid arthritis and frozen shoulder. When they are sick, the patients are very painful. The domestic treatment of local inflammation and local pain mostly adopts oral medicine, injection medicine, traction, massage, surgery and other treatment methods. Oral medicine has many complications and side effects, and the amount of effective medicine to reach the lesion is insufficient. It is necessary to take the medicine every day without interruption. The processing procedure of the medicine is complicated and the production cost is relatively high. Traction and massage can only relieve the patient's pain, and treat the symptoms but not the root cause. Because it involves technical problems of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/70A61P29/00A61K31/045A61K31/125A61K31/135
Inventor 黄文荣马静周菲娅武小赟
Owner GUIZHOU BAIHUA PHARMA
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